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Glutathione Peroxidase

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An enzyme catalyzing the oxidation of 2 moles of glutathione in the presence of hydrogen peroxide to yield oxidized glutathione and water. EC 1.11.1.9.

Also Known As:

Glutathione Lipoperoxidase; Selenoglutathione Peroxidase; Lipoperoxidase, Glutathione; Peroxidase, Glutathione; Peroxidase, Selenoglutathione; Glutathione:hydrogen-peroxide oxidoreductase

Networked: 2676 relevant articles (87 outcomes, 345 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Huang, Guan-Jhong: 19 articles (12/2013 - 11/2009)
2.	Huang, Shyh-Shyun: 18 articles (12/2013 - 06/2010)
3.	Deng, Jeng-Shyan: 13 articles (12/2013 - 09/2011)
4.	Hou, Wen-Chi: 10 articles (12/2013 - 06/2010)
5.	Sultana, Sarwat: 10 articles (09/2013 - 08/2004)
6.	Peng, Wen-Huang: 9 articles (05/2015 - 08/2007)
7.	Pedraza-Chaverri, José: 8 articles (11/2013 - 04/2004)
8.	Popova, T N: 7 articles (11/2015 - 06/2002)
9.	Kuo, Yueh-Hsiung: 7 articles (12/2013 - 06/2010)
10.	Stojiljković, Vesna: 6 articles (09/2015 - 01/2006)

Related Diseases

1.	Body Weight (Weight, Body) 12/01/1997 - "In rats fed the OK diet, no effect of oxidized oil feeding on the body weight gain, of the TBA value in plasma, or of glutathione peroxidase activities of plasma and liver was observed. " 11/15/1987 - "Tissue and blood plasma glutathione peroxidase activity was measured in vehicle-treated animals fed the control diet and BSC and BTC diets for 5 wk. The results indicate that body weights were comparable among the various dietary groups. " 07/01/1985 - "Piglet blood glutathione peroxidase was not related to piglet body weight. " 07/01/1985 - "Body weight and piglet survival were monitored in order to assess the relationship between these two factors and blood glutathione peroxidase activity. " 12/01/2011 - "The purpose of this study was to determine glutathione peroxidase (GSHPx) activity in the liver of red deer in relation to selenium concentrations in the liver, as well as to evaluate changes in GSHPx activity according to sex, body weight and season of the year. "
2.	Neoplasms (Cancer) 01/01/2015 - "Hypermethylation of GPX3 (glutathione peroxidase 3) promoter has been identified in various cancers. " 01/01/2015 - "Decreased glutathione peroxidase 3 (GPX3) expression has been identified in numerous solid tumors. " 01/01/2015 - "Hypermethylation of GPX3 (glutathione peroxidase 3) promoter has been identified in various solid tumors. " 01/01/2015 - "Hypermethylation of GPX3 (glutathione peroxidase 3) promoter has been identified in various solid tumors. " 04/01/2014 - "Therefore, our findings indicate that PRDX6 promotes lung tumor growth via increased glutathione peroxidase and iPLA2 activities. "
3.	Ischemia 09/01/2001 - "In this study we have addressed the importance of a functional glutathione peroxidase in a mouse ischemia/reperfusion model. " 01/01/2014 - "Glutathione peroxidase levels were found to be significantly lower in the control groups after 0, 3, 9 and 12 hours of ischemia. " 08/18/2004 - "Before ischemia, the levels of lipid peroxide and the glutathione peroxidase (GPx) activity were higher in the FOD group than in the RD group. " 11/01/2000 - "The heart's primary defense against peroxide, glutathione peroxidase, is depleted during ischemia. " 11/01/1999 - "The loss of glutathione peroxidase activity after the ischemia-reperfusion was also effectively prevented by the Shengmai San pre-administration whereas the activity was considerably decreased in the damaged brain. "
4.	Inflammation 01/01/2015 - "Along with a worsened cardiovascular profile, the black group had higher haemostatic-, inflammation- and oxidative stress markers as well as decreased glutathione peroxidase activity. " 01/01/2013 - "Correlation analysis identified a significant (p<0.001) linear relationship between inflammatory markers (AOPP/nitrite: r = 0.877), inflammation and antioxidant/oxidant status (AOPP/glutathione peroxidase (GPX): r = 0.902, AOPP/GSH: r = 0.806, Nitrite/GPX: 0.773, Nitrite/LPO: 0.805, MDA/MPO: 0.718), and antioxidant/oxidant levels (GPX/MDA: r = 0.768) in chagasic subjects. " 08/08/2012 - "Inflammation was alleviated, and activity of glutathione peroxidase was enhanced. " 01/01/2005 - "Induction of extracellular glutathione peroxidase occurs in airway inflammation and undoubtedly plays an important defense against oxidative injury to the airway surface." 05/01/2000 - "In low activity of glutathione peroxidase, inflammation gains activity, nonspecific resistance weakens, excretion of some metabolites inhibits vs patients with high activity of this enzyme. "
5.	Infection 10/01/2014 - "Glutathione peroxidase activity in plasma and liver tissue remained unaffected by A.pp.-infection. " 07/01/2007 - "Identification and cloning of the antioxidant enzyme, glutathione peroxidase, of white shrimp, Litopenaeus vannamei, and its expression following Vibrio alginolyticus infection." 01/01/2015 - "Therapeutic Efficacy of a Subunit Vaccine in Controlling Chronic Trypanosoma cruzi Infection and Chagas Disease Is Enhanced by Glutathione Peroxidase Over-Expression." 09/01/2003 - "As far as sheep is concerned, the results also indicate, that there is a defect in oxidative defense connected with increased susceptibility to scrapie infection in the form of lowered glutathione peroxidase activity." 09/01/2003 - "In the sheep, the results indicated a relationship between decreased glutathione peroxidase activity, and possibly also SOD1 activity, and increased susceptibility to scrapie infection. "

Related Drugs and Biologics

1.	Superoxide Dismutase
2.	Catalase
3.	Enzymes
4.	Glutathione (Reduced Glutathione)
5.	Malondialdehyde (Propanedial)
6.	Selenium
7.	Glutathione Reductase (Glutathione-Disulfide Reductase)
8.	ebselen
9.	Glutathione Transferase (Glutathione S-Transferase)
10.	Aspartate Aminotransferases (Aspartate Transaminase)

Related Therapies and Procedures

1.	Intraperitoneal Injections
2.	Drug Therapy (Chemotherapy)
3.	Oral Administration
4.	Aftercare (After-Treatment)
5.	Radiotherapy