Transfusion Reaction

Complications of BLOOD TRANSFUSION. Included adverse reactions are common allergic and febrile reactions; hemolytic (delayed and acute) reactions; and other non-hemolytic adverse reactions such as infections and adverse immune reactions related to immunocompatibility.

Also Known As:

Acute Hemolytic Transfusion Reaction; Blood Transfusion-Associated Adverse Reactions; Delayed Serologic Transfusion Reaction; Febrile Non-Hemolytic Transfusion Reaction; Hemolytic Transfusion Reaction; Hypotensive Transfusion Reaction; Post-Transfusion Purpura; Posttransfusion Purpura; TAGHD; Transfusion-Associated Allergic Reaction; Transfusion-Associated Circulatory Overload; Transfusion-Associated Dyspnea; Transfusion-Associated Graft Vs. Host Disease; Transfusion-Transmitted Infection; Allergic Reaction, Transfusion-Associated; Blood Transfusion Associated Adverse Reactions; Circulatory Overload, Transfusion-Associated; Circulatory Overloads, Transfusion-Associated; Dyspnea, Transfusion-Associated; Febrile Non Hemolytic Transfusion Reaction; Hemolytic Transfusion Reactions; Infection, Transfusion-Transmitted; Post Transfusion Purpura; Posttransfusion Purpuras; Purpura, Post-Transfusion; Purpura, Posttransfusion; Reaction, Hemolytic Transfusion; Reaction, Hypotensive Transfusion; Reactions, Hemolytic Transfusion; Transfusion Associated Allergic Reaction; Transfusion Associated Circulatory Overload; Transfusion Associated Dyspnea; Transfusion Associated Graft Vs. Host Disease; Transfusion Reaction, Hemolytic; Transfusion Reaction, Hypotensive; Transfusion Reactions; Transfusion Reactions, Hemolytic; Transfusion Reactions, Hypotensive; Transfusion Transmitted Infection; Transfusion-Associated Circulatory Overloads; Transfusion-Transmitted Infections; Delayed Hemolytic Transfusion Reaction

Networked: 1887 relevant articles (56 outcomes, 92 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Sickle Cell Anemia (Hemoglobin S Disease)
2.	Transfusion Reaction
3.	Hemolysis
4.	Infections
5.	Transfusion-Related Acute Lung Injury

Experts

1.	Hendrickson, Jeanne E: 12 articles (11/2020 - 03/2009)
2.	Nathalang, Oytip: 11 articles (10/2021 - 01/2014)
3.	Zimring, James C: 11 articles (01/2018 - 12/2007)
4.	Cognasse, Fabrice: 10 articles (03/2022 - 12/2008)
5.	Castilho, Lilian: 10 articles (01/2021 - 01/2002)
6.	Tobian, Aaron A R: 10 articles (01/2020 - 06/2008)
7.	Tormey, Christopher A: 9 articles (07/2022 - 03/2009)
8.	Intharanut, Kamphon: 9 articles (10/2021 - 01/2014)
9.	Garraud, Olivier: 9 articles (01/2020 - 12/2008)
10.	Ness, Paul M: 9 articles (01/2020 - 06/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Transfusion Reaction:

1.	AntibodiesIBA 02/01/1982 - "Although no acute transfusion reactions were observed, there was a significant reduction in survival rate of the transfused erythrocytes correlated with the level of antibodies in recipient's serum. " 12/01/1999 - "The clinical significance of antibodies in 14 of the sera was known: three (anti-Ata (two), -JMH) caused accelerated clearance of 51Cr-labelled cells, five (anti-'MiIII', -Yta, three unidentified) caused haemolytic transfusion reactions and six (anti-Yta, -Ge, -JMH, -Xga, -Kna (two)) did not appear to affect red cell survival. " 01/01/1980 - "Anti-Ina antibodies could possibly cause a transfusion reaction since In(a+) red cells when transfused into individuals possessing anti-Ina antibodies are eliminated from the circulation within 20 minutes." 02/01/2021 - "Many studies demonstrated that some antibodies including anti-S, anti-s, and anti-U may cause acute and delayed transfusion reactions and hemolytic disease of the fetus and newborn. " 12/01/2007 - "To study the relationship between antibodies detected in patients' and/or donors' sera and the clinical features of acute non-haemolytic transfusion reactions (ANHTRs), and to determine any gender-related difference. "
2.	AntigensIBA 07/01/2018 - "This is the first report of DIA and DIB allele frequencies among southern Thais, which is beneficial for not only creating information for estimating risk of alloimmunization, but also providing antigen-negative red cell donors to prevent both alloimmunization and adverse transfusion reactions." 05/01/2018 - "Novel feline RBC antigens might contribute to decreased efficacy of RBC transfusion and increased incidence of acute transfusion reactions (ATR). " 08/01/2023 - "The difference in antigen density between adult and infant RBCs may be a possible reason that leads to severe HDFN but not transfusion reaction. " 05/02/2023 - "Hemolytic transfusion reaction (HTR) is an important type of transfusion-associated reaction and usually occurs after alloimmunization to red blood cell antigens. " 07/01/2022 - "The Rhesus antigens that produce most of the immunogenic transfusion reactions are D, C, c, E, and e. "
3.	Nucleic AcidsIBA 08/01/2009 - "These processes have been shown to effectively prevent proliferation of nucleic acid-containing microbes, thereby providing broad protection against transfusion-transmitted infection. " 01/01/2019 - "Nucleic acid amplification test: Bridging the gap in blood safety & re-evaluation of blood screening for cryptic transfusion-transmitted infection among Indian donors." 09/01/2018 - "The prevalence of transfusion-transmitted infections and nucleic acid testing among blood donors in Majmaah, Saudi Arabia." 01/01/2015 - "To prevent transfusion-transmitted infections via PCs, different pathogen reduction (PR) systems have been developed that inactivate the nucleic acids of contaminating pathogens by chemical cross-linking, a mechanism that may also affect platelets' nucleic acids. " 01/01/2014 - "Individual donation nucleic acid technology testing to minimize human immunodeficiency virus-1, hepatitis C virus, and hepatitis B virus transfusion transmitted infections."
4.	N-acetyltalosaminuronic acid (NAT)IBA 05/01/2016 - "Blood product safety was significantly improved by the introduction of NAT testing in the late 1990s, resulting in a strong decrease of transfusion-transmitted infections (TTIs). " 01/01/2019 - "This study was conducted to determine the time trend of NAT positivity and seroprevalence of transfusion-transmitted infections (TTIs) through a period of six years and evaluate the strength of NAT as a supplementary test in identifying the cryptic carriers in blood donor population. " 03/23/2022 - "In summary, NAT screening in blood donations reduces the risk of transfusion-transmitted infections and shortens the window period for serological marker screening. " 08/01/2017 - "Although the positivity rate for NAT testing is low but in view of the high prevalence of transfusion transmitted infections in our country, we recommend the parallel use of both serology and NAT screening of all donated blood." 12/01/2016 - "ID-NAT would prevent an estimated 25, 6, and 9 HBV, HCV, and HIV transfusion-transmitted infections per 100,000 donations, respectively. "
5.	Oxygen (Dioxygen)IBA 09/01/2008 - "They have a prolonged shelf life, do not require cross-matching, are associated with few transfusion reactions, and are effective in delivering oxygen to the tissues. " 01/01/2018 - "The results of this initial study suggest that when a single animal receives multiple blood-product transfusions, the risk of an immunologic transfusion reaction can be reduced by ensuring that the blood products are obtained from a single donor, performing a crossmatch prior to transfusion, and the use of synthetic products to increase the oxygen carrying capacity of fetal blood." 03/01/2020 - "Perioperative adequate hydration, warming, oxygen supply and transfusion protocols are mandated to prevent SCC and transfusion reactions. " 01/01/2011 - "Several years ago, researchers reported several complications produced after blood transfusions such as transfusion reactions, the transmission of a variety of infectious agents, etc. Recently, many authors appreciate that the stored blood transfusions (SBT) create an important damage for patients' life, because of oxygen metabolism disturbances, induced earlier, after three repeated transfusions and maintained longtime after. " 01/01/1998 - "Currently available cell-free hemoglobin-based oxygen-carrying solutions present oxygen transport and exchange properties similar to blood and potential benefits over conventional transfusion, including large supply, absence of transfusion reactions, no need for cross-matching, no risk for transmission of disease and long shelf life. "
6.	Immunoglobulin G (IgG)IBA 06/01/2022 - "A chemiluminescence assay was used to detect the presence of SARS-CoV-2 IgG antibody in serum samples in addition to recommended transfusion transmitted infections tests and Signal to Cut Off (S/C) > 1 was considered as reactive for antibody as per manufacturer's instructions. " 10/06/2020 - "Anti-Lan antibody is an immunoglobulin G (IgG) antibody that is known to cause delayed hemolytic transfusion reactions in adults as well as hemolytic disease in fetuses and newborns, however with variable clinical significance ranging from mild to severe. " 05/01/2019 - "In the setting of an IgG-mediated delayed hemolytic transfusion reaction (HTR), most RBC clearance is typically extravascular, presumably by phagocytosis by liver and splenic macrophages. " 07/01/2015 - "Rhesus (Rh) mediated hemolytic transfusion reactions (HTR) are usually immunoglobulin G mediated and delayed onset. " 01/01/2013 - "Anti-U is of immunoglobulin G class and can cause hemolytic transfusion reaction and HDFN. "
7.	Immunoglobulin A (IgA)IBA 01/01/2015 - "The entity of immunoglobulin A-related anaphylactic transfusion reactions is not evidence based." 11/01/2014 - "Of the 22 362 IgA measurements performed on 19 737 patients over 10 years, a total of 168 relative IgA-deficient patients were identified; 39 of these patients were also transfusion recipients and 4 of 39 (10%) experienced a severe allergic transfusion reaction (SALTR). " 11/01/2014 - "This retrospective study evaluated the number of severe allergic transfusion reactions in relative IgA-deficient patients who were transfused with unwashed blood products. " 11/01/2014 - "Relative IgA-deficient recipients have an increased risk of severe allergic transfusion reactions." 08/01/2012 - "Implementation of these tests would make it possible to supply appropriate products from IgA SD donors to prevent anaphylactic transfusion reactions in patients."
8.	SteroidsIBA 03/01/2003 - "At present, there is really no satisfactory treatment of severe haemolytic transfusion reactions involving the ABO system other than the use of steroids that at best are palliative in their effects. " 01/01/1983 - "Steroid-responsive post-transfusion purpura." 04/01/1982 - "An unusual patient with post-transfusion purpura is described who had a rapidly rising platelet count with high dose steroid treatment in the presence of an increasing anti-PlA1 antibody titre. " 08/01/1962 - "Use of steroids in hemolytic transfusion reaction." 05/20/1978 - "Post-transfusion purpura cured by steroid therapy in a man."
9.	IsoantibodiesIBA 11/01/2017 - "Study patients undergoing subsequent transfusion were evaluated for reported transfusion reactions and development of new alloantibodies. " 05/01/2015 - "In this study, we evaluated the frequency of alloantibodies in thalassemic patients with previous history of transfusion reactions. " 01/01/2013 - "This study was planned to detect the presence of inhibitors in our PWH and to determine the presence of transfusion transmitted infections (TTI) markers and clinically significant red cell alloantibodies in these patients. " 01/01/2012 - "This study revealed a relatively high frequency of D and a low frequency of demonstrable clinically significant alloantibodies that may cause hemolytic disease of the newborn or hemolytic transfusion reactions among pregnant women in Kampala, with anti-S being the most frequent antibody specificity." 09/30/1941 - "Studies are reported on an individual agglutinogen (Rh) in human blood which has been found to be of clinical importance because occasionally it gives rise to the formation of immune isoantibodies in man, a peculiarity which leads to untoward transfusion reactions. "
10.	Blood Group Antigens (Blood Groups)IBA 01/01/2014 - "This is the first to report of Kidd blood group allele frequencies in Thais, which is beneficial for the prevention of both alloimmunization and adverse transfusion reactions." 06/27/2022 - "This study was aimed at determining the prevalence estimate and association of transfusion-transmitted infections (TTIs) with ABO and Rh blood groups among blood donors at the King Faisal Specialist Hospital and Research Center (KFSH & RC) in the western region of Saudi Arabia. " 10/21/2020 - "Therefore, the aims of this study were to investigate the frequency of AB blood groups in non-pedigree domestic cats in Central Italy and estimate the risk of a life-threatening transfusion reaction and neonatal isoerythrolysis, caused by mismatched transfusion or incompatible random mating, respectively. " 01/01/2013 - "In this study, we report a case with the rare Bombay blood group that was misdiagnosed as the O blood group and developed a hemolytic transfusion reaction. " 08/01/2011 - "KODE technology allows for the artificial attachment of incompatible blood group antigens, plus visualization and recovery constructs onto red blood cells (RBCs), making them potentially suitable to study both transfusion reactions and determine in vivo cell survival. "

Therapies and Procedures

1.	Therapeutics 01/01/2005 - "It is proposed that CR1-based therapeutics have potential for effective and safe prophylactic short-term use and for treatment of hemolytic transfusion reactions." 01/28/2021 - "We emphasise the need to be aware of the potential risk of transfusion reactions and disease worsening with convalescent plasma administration and to weigh the risk and benefits of this therapy before administration to patients and propose that further study be done regarding the potential risks of convalescent plasma." 06/28/2018 - "This study allowed for a better assessment and understanding of transfusion reactions, which will help to improve the quality of blood circulation and provide greater safety of patients undergoing transfusion therapy. " 01/01/2023 - "Appropriate diagnostic tests in the face of a potential transfusion reaction are important to tailor effective therapy." 01/01/2020 - "Allergic transfusion reactions (ATRs) are a common adverse reaction to transfusion therapy and can be potentially fatal. "
2.	Donor Selection 07/23/1987 - "Patients and physicians need to understand that an absolutely safe blood supply is an unattainable goal, but that current approaches to donor selection and testing are highly effective in minimizing the risk of transfusion-transmitted infection." 07/20/2012 - "Despite screening blood donations with advanced technologies and improved donor screening, the risk of transfusion-transmitted infections persists. " 01/01/2002 - "Careful donor selection has reduced but not eliminated the risk of transfusion-transmitted infections. " 10/01/1999 - "Efficacy of donor screening for HTLV-I and the natural history of transfusion-transmitted infection." 01/01/2021 - "Proper donor selection and screening of the donated blood for major transfusion-transmitted infections evidently reduced challenge in blood safety. "
3.	Platelet Transfusion (Blood Platelet Transfusions) 11/18/2015 - "There was a significant reduction in the number of platelet transfusions per participant in the standard trigger group (two studies, mean difference -2.09, 95% CI -3.20 to -0.99; low-quality evidence).One study reported on the number of transfusion reactions. " 11/01/2019 - "Investigation of factors associated with allergic transfusion reaction due to platelet transfusion and the efficacy of platelets resuspended in BRS-A in adult patients." 05/10/2013 - "There were five bacterial transfusion transmitted infections associated with platelet transfusion reported during the study period. " 09/01/2004 - "Randomized trials prove that leukoreduced and ABO identical platelet transfusions reduce the risks of HLA alloimmunization and platelet transfusion refractoriness (both leukoreduction and ABO matching), transfusion reactions (leukoreduction) and CMV transmission (leukoreduction). " 06/01/2023 - "Though rare, acute hemolytic transfusion reaction (AHTR) may occur following minor ABO-incompatible platelet transfusion. "
4.	Blood Transfusion (Blood Transfusions) 08/02/2003 - "The safety and quality of blood transfusions can be improved if this knowledge is incorporated into ongoing education about blood transfusions and in the prevention and treatment of transfusion reactions." 01/01/2023 - "The aim of this study was to assess the seroprevalence rates of transfusion transmitted infections among blood donors in Basra, Iraq from 2019 to 2021 as groundwork for providing safe blood transfusion in Iraq. " 01/01/2021 - "Objective: This study aimed to describe transfusion reactions of pediatric patients from a National Center for Children's Health in China and to examine reaction incidents, reaction types by blood transfusion, and the associated blood products resulting in transfusion reactions. " 01/01/2021 - "Transfusion-Transmitted Infections and associated risk factors at the Northern Zone Blood Transfusion Center in Tanzania: A study of blood donors between 2017 and 2019." 01/01/2019 - "In the present study, we sought to determine the prevalence of specific transfusion transmitted infections (TTIs) and the associated risk factors among blood donors at a newly established regional blood transfusion center in Barentu, Eritrea. "
5.	Blood Component Removal (Apheresis) 03/01/2011 - "The 2% CHX/IPA single-step skin swabs are more effective in preventing bacterial contamination of apheresis PLT components than a two-step P-I skin disinfection method and may reduce the risk of septic transfusion reactions. " 11/01/2013 - "Transfusions of pooled or apheresis platelets are seen as equally effective in increasing platelet counts with similar rates of transfusion reactions. " 12/01/2013 - "This study shows that among paediatric recipients, cutaneous signs are predominant in allergic adverse transfusion reactions and that the apheresis platelet concentrate is the most frequently involved blood component." 08/01/2012 - "The purpose of this study was to assess the incidence of febrile nonhemolytic transfusion reactions (FNHTRs) to concurrent transfusions of prestorage-leukoreduced (PreSLR) pooled platelets, poststorage-leukoreduced (PostSLR) pooled platelets, nonleukoreduced (NonLR) pooled platelets, and apheresis single-donor platelets (SDPs) to compare the rates of FNHTRs to PreSLR vs PostSLR pooled platelets. " 06/01/2009 - "The goal of this study was to assess transfusion reactions arising from prestorage-pooled platelet (PSPP) infusions compared with apheresis single-donor platelets (SDPs) and poststorage-pooled, whole blood-derived random-donor platelets (RDPs). "