Nucleic Acids

11/01/2014 - "Successful delivery of nucleic acids into cancer cells with the use of nanoparticles would be a significant improvement for medical and cellular biology. "
01/01/2013 - "The field of cancer nanomedicine is considered a promising area for improved delivery of bioactive molecules including drugs, pharmaceutical agents and nucleic acids. "
05/01/2011 - "Large unilaminary vesicles (LUV) with encapsulated nucleic acids designated stabilized-plasmid-lipo-particle (SPLP) have showed promising results in terms of systemic stability and accumulation in tumor tissue due to the enhanced permeability and retention effect (EPR). "
06/01/2011 - "In the past decade a wealth of information indicating the potential use of circulating nucleic acids for cancer screening, prognosis and monitoring of the efficacy of anticancer therapies has emerged. "
01/01/2013 - "The phenomenon of cell-free nucleic acids (cfNA) circulating in plasma has opened new areas of research for the study of the pathobiology of many diseases, particularly cancer. "

06/01/2015 - "We conclude that highly sensitive multiplex PCR assays constitute a useful screening tool, but that positive results might need to be confirmed by independent methods to discriminate active infection from asymptomatic faecal shedding of nucleic acids. "
06/01/2004 - "The advent of molecular techniques, in particular those based on the in vitro amplification of nucleic acids, has dramatically improved our ability to detect infections caused by parasites. "
09/01/2008 - "The measurement of circulating nucleic acids has transformed the management of chronic viral infections such as HIV. "
06/01/1996 - "Amplification of viral nucleic acids from the cerebrospinal fluid (CSF) has considerably improved the diagnosis of several acute, subacute and chronic viral infections of the nervous system. "
07/01/1983 - "Treatment of mice with different cellular nucleic acids prior to inoculation of influenza virus A/PR8/34 (H1N1) conferred--in some cases--a nonspecific protection against the experimental infection. "

10/01/2008 - "The resultant responses may vary depending on the balance between immune responses to and metabolism of nucleic acids, thereby contributing not only to the host defense, but also to the homeostatic clearance of host dying cells, or even to deleterious autoimmune diseases."
08/01/2015 - "Elevated levels of these nucleic acids have been found not only in acute, but also in chronic conditions, including autoimmune diseases. "
02/01/2015 - "Inappropriate recognition of host nucleic acids also results in autoimmune disease. "
01/01/2015 - "However, inappropriate detection of aberrant self nucleic acids is implicated in the development of autoimmune diseases. "
05/01/2014 - "Inappropriate or chronic detection of self nucleic acids by the innate immune system underlies many human autoimmune diseases. "

04/01/1992 - "Further analysis of nucleic acids in purified scrapie prion preparations by improved return refocusing gel electrophoresis."
01/01/1986 - "Molecular hybridization studies with scrapie brain nucleic acids. "
01/01/1986 - "Molecular hybridization studies with scrapie brain nucleic acids. "
07/01/1985 - "This study reports the partial characterization of nucleic acids present in gradient fractions enriched for large membrane vesicles from scrapie-infected and uninfected hamster brains. "
07/10/2012 - "It has been shown that nucleic acids catalyze the misfolding of cellular PrP into a scrapie-like conformer. "

10/01/2004 - "Furthermore, heat shock treatments in the present study caused the leakage of nucleic acids from V. parahaemolyticus cells. "
01/01/2015 - "Extracorporeal shock wave (SW) therapy has been studied in the transfection of naked nucleic acids into various cell lines through the process of sonoporation, a process that affects the permeation of cell membranes, which can be an effect of cavitation. "
08/29/2014 - "The results imply that thermophilic Ta-Csp has a more rigid structure and may not need high structural flexibility to accommodate nucleic acids upon cold shock compared to its mesophile and psychrophile counterparts."
10/01/2012 - "One of the main consequences of cold shock is stabilization of the secondary structures in nucleic acids leading to hindrance of RNA degradation. "
01/01/2012 - "Cold shock domain protein from Philosamia ricini prefers single-stranded nucleic acids binding."