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Immune System Diseases (Immune Disorders)

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Disorders caused by abnormal or absent immunologic mechanisms, whether humoral, cell-mediated, or both.

Also Known As:

Immune Disorders; Immune Disease; Immune Disorder; Immune Diseases; Disease, Immune; Disorders, Immune; Diseases of Immune System; Immunological Diseases; Disease, Immune System; Disease, Immunologic; Disease, Immunological; Diseases, Immune; Diseases, Immune System; Diseases, Immunologic; Diseases, Immunological; Disorder, Immune; Immune System Disease; Immunologic Disease; Immunological Disease; Immunologic Diseases

Networked: 2064 relevant articles (74 outcomes, 143 trials/studies)

Relationship Network

Disease Context: Research Results

Immune System Diseases: 2064

Related Diseases

1.	Neoplasms (Cancer)
2.	Hemorrhage
3.	Hemophilia A (Haemophilia)
4.	Rheumatoid Arthritis
5.	Hypersensitivity (Allergy)

Experts

1.	Delgado, Mario: 10 articles (09/2015 - 06/2007)
2.	Gonzalez-Rey, Elena: 8 articles (09/2015 - 06/2007)
3.	Hewison, Martin: 6 articles (02/2012 - 08/2008)
4.	Holland, Steven M: 5 articles (09/2013 - 09/2002)
5.	Kubo, Masato: 5 articles (09/2012 - 08/2003)
6.	Fischer, Alain: 5 articles (07/2009 - 07/2003)
7.	Asadullah, Khusru: 5 articles (07/2009 - 01/2002)
8.	Yang, Hao: 4 articles (02/2015 - 07/2011)
9.	Wan, Lin: 4 articles (02/2015 - 07/2011)
10.	Lu, Xiaofeng: 4 articles (02/2015 - 07/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Immune System Diseases:

1.	AntibodiesIBA 01/01/2014 - "The knowledge that auto-antibodies in subjects with SLE display differential immuno-reactivity may help to improve existing diagnostics and may lead to a better understanding of the pathogenesis of auto-immune disorders." 01/01/2015 - "Anti-cytokine therapeutic antibodies have been demonstrated to be effective in the treatment of several auto-immune disorders. " 04/01/2006 - "When the biological sample contains heterophilic antibodies (such as in patients with auto-immune diseases), these non-specific antibodies can cause false positive results. " 01/01/2015 - "Given that LTF/anti-LTF antibodies represent a potential diagnostic/prognostic biomarker and a therapeutic target in patients with immune disorders, we wished, in the present study, to generate a novel human LTF- (huLTF-) specific mAb suitable for detailed analyses on the expression and function of mbLTF as well as for deciphering the underlying mechanisms. " 09/01/2009 - "Further studies in the field of neutrophil immunology will facilitate the prevention and management of transfusion reactions and immune diseases caused by neutrophil antibodies."
2.	Proteins (Proteins, Gene)IBA 01/01/2015 - "Here, we summarize more than decade of studies on the ShcC expression and function in normal brain, age-related brain pathologies and immune disorders with a focus on the interactions of ShcC with signaling proteins/pathways, and the possible implications of these interactions for changes associated with aging. " 07/01/2006 - "Our study demonstrates the presence of naturally occurring genetic variations in the cytokine proteins that may affect their expressions and functions with possible roles in complex human disease, such as immune diseases." 09/15/2015 - "Many functionally important interactions between genes and proteins involved in immunological diseases and processes are unknown. " 06/03/2015 - "Gene ontology and KEGG analysis were conducted among the differentially expressed genes and proteins, revealing that immune system process and response to stimulus were the top two biological processes, and immune system, signaling molecules and interaction, and immune diseases were the differential pathways activated. " 05/01/2015 - "Our data reveal a novel function for MS4A family proteins in regulating trafficking and signaling, which could have implications in both proliferative and immunological diseases. "
3.	rituximab (Mabthera)FDA Link 07/01/2005 - "The monoclonal antibody anti-CD20 (rituximab), able to suppress the tumoral cells and change the B-cell repertoire is the most promising treatment to cure immune disorders related to NHL. " 09/01/2013 - "Among the alternative medications under investigation, rituximab, used to treat successfully various auto-immune disorders, has fewer side effects. " 01/01/2013 - "A large number of auto-immune diseases are treated with rituximab, an antibody against CD20 that depletes most of the B-cells in the organism. " 08/31/2010 - "Rituximab is a chimeric anti-CD20 monoclonal antibody that has revolutionised the treatment of many B-cell malignancies, and is now increasingly being used in non-malignant conditions such as auto-immune disorders. " 02/01/2008 - "Rituximab is increasingly used off label for difficult-to-treat auto-immune diseases. "
4.	hydroxide ionIBA 02/01/1994 - "In vivo, 1,25(OH)2D3 is particularly effective in preventing auto-immune diseases such as experimental auto-immune encephalomyelitis, murine lupus, and diabetes in NOD mice. " 03/01/2000 - "In the present review, a summary is given on the use of the 1alpha,25(OH)(2)D(3) analogues for the treatment of cancer, skin and immune disorders and for the prevention of graft rejection. " 07/01/1998 - "In the present review, a summary is given on the use of the 1 alpha,25(OH)2D3 analogues for the treatment of psoriasis, cancer and immune disorders together with new insights in the mechanism of action of these analogues." 10/01/2010 - "Therefore, 1,25(OH)(2)D(3) enabled by IL-2 can directly enhance the regulatory potential of CD4+CD25+ T cells to control immune disease." 02/01/2012 - "The biologically active metabolite of vitamin D, 1,25(OH)(2)D(3), affects mineral homeostasis and has numerous other diverse physiologic functions including effects on growth of cancer cells and protection against certain immune disorders. "
5.	Factor VIII (Coagulation Factor VIII)IBA 07/01/2012 - "Acquired haemophilia A is a rare auto-immune disease caused by an inhibitory antibody to factor VIII. Patients with this disorder are at high risk of severe bleeding until the inhibitor has been eradicated. " 07/01/2011 - "Acquired haemophilia A is an auto-immune disease caused by an inhibitory antibody to factor VIII. The pattern of bleeding varies but patients remain at risk of life threatening bleeding until the inhibitor has been eradicated. " 01/01/2010 - "Acquired haemophilia A is an auto-immune disease caused by an inhibitory antibody to factor VIII. Patients with an acquired factor VIII inhibitor are at risk of life- and limb-threatening bleeding until the inhibitor has been eradicated. "
6.	AntigensIBA 09/01/2013 - "Hypomorphic or hypermorphic gene mutations often occur in human diseases; when coupled with the fact that humans are exposed to naturally encountered antigens and pathogens, this helps to make the case that the study of immunological diseases in humans should be at the forefront of basic immunological research. " 09/01/1990 - "Because clinical studies indicate that these antigens are involved in mediating corneal graft rejection and possibly in glaucomatous disease of the eye, the presence of both class I and II HLA in the corneal endothelium and in the trabecular cells has important implications for an understanding of immune disorders in the anterior segment of the eye. " 04/01/2015 - "The human leukocyte antigen (HLA) region is the key susceptibility locus in many immunological diseases. " 08/29/2014 - "Especially in western civilizations, immune diseases that are driven by innocuous (auto- or allo-) antigens are gradually evolving to become pandemic threats. " 05/01/2014 - "Infiltration of inflammatory cells as the initial event in the development of new psoriatic plaques together with the defined inflamed areas of such lesions argues for an immunological disease with a local production of a causal antigen. "
7.	AutoantibodiesIBA 05/01/1999 - "In contrast, 6 of 53 patients without concurrent immune diseases and no or low-titer autoantibodies had treatment-related remission. " 05/01/1999 - "Patients were selected for study if they had been screened for autoantibodies and concurrent immune diseases and if viral genotyping had been performed or was possible. " 10/12/2012 - "The importance of the autoantibodies for an early diagnosis of immune disease." 09/01/2012 - "Thus, application of drugs to inhibit Syk activity can affect the development of immune diseases mediated by autoantibodies, while unexpected systemic effects by the inhibition may be concerned because Syk has multiple physiological functions. " 10/01/2011 - "Both MG and PSC include an autoimmune pathogenesis, so there is some evidence that patients with MG or PSC have a higher risk of developing autoantibodies and other immune disorders than normal controls, but the coexistence of these two disorders has never been documented. "
8.	Immunoglobulin G (IgG)IBA 02/06/2014 - "However, IgG4 is also known to undergo Fc-mediated aggregation and has been implicated in auto-immune disease pathology. " 01/01/2011 - "This article will discuss IgG4 structure and function, the unique phenomenon of half-antibody exchange, and the implications of IgG4 biology for its proposed role in immunologic diseases. " 01/29/2009 - "These results establish STIM1 as a novel and essential component of FcgammaR activation and also indicate that inhibition of STIM1-dependent signaling might become a new strategy to prevent or treat IgG-dependent immunologic diseases." 01/01/2006 - "The majority of these deficiencies are subtle IgG subclass deficits, whereas more severe humoral immune disorders are a rare finding. " 01/01/1999 - "A common variable immune disease was diagnosed in three patients that was characterized by an additional defect in the IgG main class. "
9.	Vitamin D FDA LinkGeneric 11/01/2014 - "Since low vitamin D status has been linked to many immune disorders, we designed this study to compare the vitamin D status in PV patients with healthy controls. " 01/01/2011 - "There is also evidence from observational studies for potential long-term programming effects of vitamin D supplementation on immunological diseases (such as type 1 diabetes and allergic diseases), with evidence supporting the role of active vitamin D as a potent immunomodulator. " 10/01/2015 - "Vitamin D dosing for infectious and immune disorders." 06/01/2012 - "Vitamin D supplementation, moderate sun exposure, and control of immune diseases." 05/01/2012 - "The effect of vitamin D supplementation on immune disorders has been a topical research focus. "
10.	Immunoglobulins (Immunoglobulin)IBA 09/04/1993 - "Human polyvalent immunoglobulins administered intravenously have shown to be effective in some immune diseases. " 01/01/2015 - "Immunoglobulin G4 (IgG4)-related disease encompasses a wide variety of immune disorders previously thought be distinct. " 06/01/2006 - "Intravenous immunoglobulin (IGIV) is used in the treatment of a wide variety of immune disorders. " 06/01/2000 - "Laboratory findings were abnormal (immunoglobulins and lymphocyte populations), suggesting an immune disorder. " 01/01/1995 - "The examinees with euthyroid condition had immune disorders with an allergic tendency (increased number of B-lymphocytes, immunoglobulins A). "

Therapies and Procedures

1.	Transplantation (Transplant Recipients) 10/01/2010 - "The transplantation of bone marrow stromal cells or mesenchymal stem cells (MSCs) has been reported to be an effective treatment for several immune disorders by modulating the inflammatory response to injury. " 01/01/2010 - "Transplantation of MSCs from bone marrow is considered safe and has been widely tested in clinical trials of cardiovascular, neurological, and immunological disease with encouraging results. " 03/01/1995 - "Information gained from these studies is already guiding the practice of autologous and allogeneic marrow transplantation and has contributed to the development of gene therapy protocols for the treatment of malignant disease, immune deficiency syndromes and lysosomal storage disorders. " 08/01/2015 - "This is the sixth special report that the European Society for Blood and Marrow Transplantation regularly publishes on the current practice and indications for haematopoietic SCT for haematological diseases, solid tumours and immune disorders in Europe. " 08/01/2014 - "Transplantation of cryopreserved umbilical cord blood (UCB) can be used to treat a multitude of haematologic and immunological diseases. "
2.	Organ Transplantation 05/01/2002 - "Because this side effect of MMF may also occur after solid organ transplantation and in other immune disorders, pharmacokinetic profiling of MPA and MPA acyl glucuronide is needed in future studies with MMF." 05/01/2013 - "The prevalence of these diseases has been increasing due to immunosuppressive, corticosteroid, and long-term antibiotic treatment following organ transplantation or after serious metabolic, hematological, or immunological diseases. " 01/01/2012 - "These results suggest that MSCs can be used in the therapy of immune disorder diseases, prevention of organ transplantation rejection and tissue injury. " 02/01/2005 - "This review discusses the advances in researches on the mechanism of MSCs' immunoregulatory function and potential clinical application in immune disease and organ transplantation." 04/01/2003 - "While its application clearly is efficacious in the inhibition of T-cell proliferation and results in the decrease of inflammatory processes, its side effects in long-term use manifested most prominently through nephrotoxicity have been the main concern against broader use of the drug in inflammatory and immune diseases other than organ transplantation. "
3.	Immunomodulation 11/01/1999 - "Also, it will be a very useful treatment for immunological diseases and extracorporeal immunomodulation." 01/01/2015 - "This study provides comprehensive mechanistic insight into helminth-induced immunomodulation, which can be therapeutically exploited to combat various auto-immune disorders." 03/01/2014 - "Altogether, engineering the environment of human MSCs to develop pre-conditioning strategies for enhancing human MSC immunomodulation may be a simple approach for improving MSC-based therapies for the treatment of inflammatory and immune diseases." 06/01/2008 - "Therefore PPI can exert immunomodulation in immunological diseases through hampering antigen processing, antigen presentation, and leucocytes transmigration." 08/01/2002 - "Although the effective mechanism of LCAP is still controversial, the removal of activated leukocyte from the peripheral blood and the reaction by blood contacting materials in Cellsorba can be triggers of the immunomodulation for the treatment of immune disorder. "
4.	Stem Cell Transplantation 03/01/2006 - "The Accreditation Subcommittee of the EBMT regularly publishes special reports on current practice of haemopoietic stem cell transplantation for haematological diseases, solid tumours and immune disorders in Europe. " 04/01/2002 - "The Accreditation Sub-Committee of the EBMT regularly publishes special reports on current practice of haemopoietic stem cell transplantation for haematological diseases, solid tumours and immune disorders. " 09/29/2005 - "Haematopoietic stem cell transplantation (HSCT) offers promise for the treatment of haematological and immune disorders, solid tumours, and as a tolerance inducing regimen for organ transplantation. " 08/01/2014 - "In this article we give an overview regarding the indications of autologous stem cell transplantation in auto-immune diseases as well as recommendations regarding post-transplant follow-up of patients." 08/01/2014 - "Patients who undergo allogeneic stem cell transplantation frequently develop an immunologic disease caused by the reactivation of the graft to the host tissues. "
5.	Therapeutics 03/01/2014 - "Notably, studies on the role of FOX family members in immune response could be helpful to further investigate pathogenesis of immunological disease and to develop a novel therapeutics approach for human diseases. " 01/01/2014 - "Thus, increased understanding of the molecular actions and transcriptional networks regulated by XBP1 in immune cells may aid in the development of potential therapeutics targeting immune disorders." 10/01/2012 - "Better characterization of pathogen-induced immune disorders and newly discovered regulators of innate immunity have now the potential to specifically withdraw prevailing subversion mechanisms and to transform antiviral treatments by introducing panviral therapeutics with less adverse effects than IFN therapies." 04/01/2009 - "Therefore, we suggest that HCA may be beneficial as therapeutics for treating inflammatory immune disorders caused by extravagant activation of Th1-mediated immune responses." 12/01/2003 - "It is for these reasons that they are considered a tempting source of candidate therapeutics for the treatment of immune disorders or of value for boosting prophylactic immune therapies. "