Acute hemolytic transfusion reaction following ABO-mismatched platelet transfusion: Two case reports.

Abstract	Acute hemolytic transfusion reaction following ABO-incompatible platelet transfusion: two case reports An ideal platelet transfusion should provide ABO identical platelet concentrate, and cross match compatibility is not routinely performed in the standard practices. However, ABO non identical platelet transfusions are not uncommon with the limited resources and short shelf life of platelet concentrate. Though rare, acute hemolytic transfusion reaction (AHTR) may occur following minor ABO-incompatible platelet transfusion. Here, we report two cases of thrombocytopenic patients (one child and one adult) type as Group B RhD positive and received Group O RhD positive platelet transfusions. Both patients experienced an AHTR evidenced by a drop in hemoglobin level, spherocytosis and small agglutinations on the blood film, and positive direct Coombs test. They were treated symptomatically, recovered and discharged well post-event without any morbidity. No anti-B isohemagglutinins titer were done to confirm the high titer of the antibody in the platelet donors. Our cases highlighted the importance of ABO-compatible platelet transfusion, especially to children and those vigilant groups of patients.
Authors	Razan Hayati Zulkeflee, Mohd Nazri Hassan, Rosline Hassan, Nur Ilyia Syazwani Saidin, Zefarina Zulkafli, Marini Ramli, Marne Abdullah, Salfarina Iberahim, Wardah Roslan, Noor Haslina Mohd Noor, Wan Suriana Wan Ab Rahman
Journal	Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis (Transfus Apher Sci) Vol. 62 Issue 3 Pg. 103658 (Jun 2023) ISSN: 1473-0502 [Print] England
PMID	36805153 (Publication Type: Case Reports, Journal Article)
Copyright	Copyright © 2023 Elsevier Ltd. All rights reserved.
Chemical References	Antibodies ABO Blood-Group System
Topics	Adult Child Humans Platelet Transfusion (adverse effects) Blood Platelets Transfusion Reaction Blood Group Incompatibility Blood Grouping and Crossmatching Drug-Related Side Effects and Adverse Reactions Antibodies ABO Blood-Group System

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