Immunoglobulin A (IgA)

Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.

Also Known As:

Networked: 13812 relevant articles (477 outcomes, 1176 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hashimoto, Takashi: 53 articles (11/2015 - 01/2002)
2.	Novak, Jan: 52 articles (07/2015 - 08/2002)
3.	Julian, Bruce A: 38 articles (07/2015 - 08/2002)
4.	Suzuki, Hitoshi: 37 articles (08/2015 - 01/2004)
5.	Tomino, Yasuhiko: 35 articles (08/2015 - 08/2002)
6.	Hashimoto, T: 35 articles (01/2015 - 01/2000)
7.	Ishii, Norito: 27 articles (11/2015 - 05/2007)
8.	Mestecky, Jiri: 26 articles (01/2014 - 08/2002)
9.	Moldoveanu, Zina: 25 articles (02/2014 - 09/2004)
10.	Monteiro, Renato C: 24 articles (12/2015 - 03/2002)

Related Diseases

1.	Infection 04/05/2006 - "At this time, total serum RV IgA, measured shortly after infection, appears to be the best marker of protection against rotavirus. " 06/23/2015 - "Furthermore, trimeric, tetrameric, and larger polymeric structures, which are minor fractions in human nasal IgA, displayed increased neutralizing potency against influenza A viruses compared with dimeric S-IgA, suggesting that the larger polymeric than dimeric forms of S-IgA play some important roles in protection against influenza A virus infection in the human upper respiratory tract. " 11/01/2000 - "The ability of mucosal and plasma IgA to inhibit HIV-1 transcytosis across the mucosal epithelium may represent an important mechanism for protection against the sexual acquisition of HIV-1 infection in HEPS individuals." 11/01/1996 - "Immunization via GALT (gut infection with TGEV) elicited high numbers of IgA ASC and high LPA responses in GALT (gut lamina propria, LP or mesenteric lymph nodes, MLN), but lower responses in BALT (bronchial lymph nodes, BLN) and induced complete protection against enteric TGEV challenge. " 08/01/1994 - "An important feature of the role of IgA in protection against infection and disease at the level of the mucosal surfaces might be the elimination of pathogens without induction of a strong inflammatory reaction. "
2.	IGA Glomerulonephritis (IGA Nephropathy) 07/01/2000 - "Patients with IgA nephropathy and those with HSN showed significantly greater levels of plasma IgA1 antibody against H parainfluenzae than patients with other renal diseases (IgA nephropathy versus other renal diseases, P = 0.008; HSN versus other renal diseases, P = 0.025). " 11/01/2008 - "CD19(+)CD5(+) B cells isolated from patients with untreated IgA nephropathy expressed higher levels of IgA, produced more IFN-gamma, and were more resistant to CD95L-induced apoptosis than cells isolated from control subjects and patients with lupus; these properties reversed with effective treatment of IgA nephropathy. " 06/01/2014 - "The remission criteria of immunoglobulin A (IgA) nephropathy have varied depending on the clinical study. " 11/01/1997 - "Published reports examining the efficacy of fish oil for preserving renal function in immunoglobulin A (IgA) nephropathy have yielded conflicting results. " 01/01/1993 - "Defective galactosylation and clearance of IgA1 molecules as a possible etiopathogenic factor in IgA nephropathy."
3.	Celiac Disease (Celiac Sprue) 09/01/2002 - "screening for celiac disease using IgA EmA assay is effective in anemic patients, including premenopausal women and patients older than 65 years, and it can be recommended in clinical practice." 01/01/2010 - "Histology is still necessary to diagnose celiac disease and IgA-AAA cannot be included in usual screening tests, because it has little to offer if compared to the well-established tTG-Ab.IgA-AAA could be an adjunctive, very useful tool to support the diagnosis of CD in case of suboptimal histology, when the biopsy is to be avoided for clinical reasons, or in case of negative parents' consensus." 01/01/1994 - "Childhood celiac disease in Estonia: efficacy of the IgA-class antigliadin antibody test in the search for new cases." 11/01/1998 - "Improved method for serological testing in celiac disease--IgA anti-endomysium antibody test: a comparison between monkey oesophagus and human umbilical cord as substrate in indirect immunofluorescence test." 03/01/1975 - "In contrast to patients with gluten-sensitive enteropathy in remission (i.e., on a gluten-free diet), jejunal IgA synthesis did not decline. "
4.	Proteinuria 10/01/2003 - "14 patients with mesangial IgA deposition showed complete remission and one patient had persistent proteinuria. " 01/01/2007 - "In 2000, while still in stable SLE remission, she was diagnosed with MM. Protein electrophoresis revealed the IgA lambda paraprotein (40.5 g/l) and she had a Bence Jones (BJ) proteinuria of the lambda light chain type. " 07/01/1983 - "A dramatic response occurred on corticosteroid and immunosuppressive therapy, characterized by clearance of proteinuria and a fall of serum IgA level to normal. " 01/01/2014 - "As such, the natural progression of patients with IgA who clinically present with normal kidney function, microhaematuria and low proteinuria had not been analysed comprehensively until the Spanish multicentre study herein analysed. " 03/01/2003 - "At study completion, we measured proteinuria and serum IgA levels and generated histological scores from kidney specimens. "
5.	Human Influenza (Influenza) 11/06/2012 - "In years 1 and 2, the mean postvaccination strain-specific to total IgA ratio was 3.1-fold (P<0.01) and 2.0-fold (P<0.03) higher among LAIV recipients with no evidence of culture-confirmed influenza illness compared with LAIV recipients who developed culture-confirmed influenza illness; a similar and consistent trend was observed for each individual study and type/subtype. " 11/06/2012 - "Mean postvaccination IgA ratios were compared for subjects with and without confirmed influenza illness by study and in pooled analyses. " 08/20/1999 - "After two doses of study drug, 62, 69 and 85% of CAIV-T recipients demonstrated a mucosal IgA response to influenza A/H1N1, A/H3N2, and B strains respectively; in comparison, 33, 0 and 17% of placebo recipients demonstrated an IgA response to the same strains (p = 0.35, 0.01 and 0.01). " 09/11/2015 - "Nasopharyngeal swabs for influenza PCR and IgA ELISA and blood for hemagglutination inhibition antibody (HAI) measurements were collected at entry, 2-5, 7-10 and 21-28 days post-vaccination. " 01/01/2015 - "Bronchoalveolar lavage fluid and lung compartments were analyzed for BAFF expression, influenza-specific S-IgA level and histological changes. "

Related Drugs and Biologics

1.	Immunoglobulin G (IgG)
2.	Antibodies
3.	Immunoglobulin M (IgM)
4.	Immunoglobulin A (IgA)
5.	Antigens
6.	Immunoglobulins (Immunoglobulin)
7.	Antigen-Antibody Complex (Immune Complex)
8.	Secretory Immunoglobulin A (SIgA)
9.	Immunoglobulin E (IgE)
10.	Vaccines

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Aftercare (After-Treatment)
3.	Oral Administration
4.	Radiotherapy
5.	Transplants (Transplant)