Isoantibodies

06/01/2014 - "In addition, a number of investigators have recently used this agent in patients with congenital haemophilia A or B and alloantibodies refractory to first-line treatment. "
01/01/2017 - "In this phase 1 dose-escalation study, we enrolled 4 healthy volunteers and 25 participants with moderate or severe hemophilia A or B who did not have inhibitory alloantibodies. "
07/23/2022 - "However, the main complication resulting from replacement treatment in hemophilia A is the development of anti-FVIII neutralizing alloantibodies, known as inhibitors, affecting approximately 25-30% of severe hemophilia A patients. "
01/01/2021 - "The association between haemophilia and the so-called 'inhibitors', alloantibodies against the infused factor able to neutralize its clotting activity, is a very rare condition. "
04/01/2020 - "Immunotolerance induction effectivity in hemophilia A children and neutralizing alloantibodies."

01/01/2023 - "The objective of this study was to assess the prevalence of anti-VWF alloantibodies in subjects with type 3 VWD enrolled in the 3WINTERS-IPS. "
02/01/2000 - "Mapping and functional studies of two alloantibodies developed in patients with type 3 von Willebrand disease."
07/01/2021 - "The homozygous variant p.Gln1311* in exon 28 of VWF is associated with the development of alloantibodies in 3 unrelated patients with type 3 VWD."
01/01/2018 - "Management of pregnancy in type 3 von Willebrand disease with alloantibodies."
10/01/2012 - "Management of delivery with FVIII/VWF concentrates in a pregnant woman with type 3 von Willebrand disease and alloantibodies."

01/01/2023 - "In the context of critical bleeding and massive transfusion (CB/MT), little is known about the development of new red blood cell (RBC) alloantibodies. "
01/01/2023 - "Red blood cell alloantibodies in the context of critical bleeding and massive transfusion."
08/01/2022 - "Transfusion of uncrossmatched ABO-compatible RBCs against alloantibodies is highly safe in patients with life-threatening hemorrhage."
09/01/2018 - "Alloantibodies and Congenital Bleeding Disorders: New Insights in the Pathogenesis and Management."
01/01/2018 - "Alloantibodies in FXIII-deficient patients also cause life-threatening bleeding complications, but they develop extremely rarely. "

01/01/2022 - "Genetic Alterations, DNA Methylation, Alloantibodies and Phenotypic Heterogeneity in Type III von Willebrand Disease."
09/01/2018 - "Alloantibodies in von Willebrand Disease."
08/01/2013 - "Alloantibodies in von Willebrand disease."
01/01/1991 - "In a review of the literature published in 1984 we identified (from 13 kindreds) 15 patients with severe von Willebrand's disease (vWD) reported to have developed alloantibodies. "
01/01/1991 - "Alloantibodies in congenital von Willebrand's disease."

11/01/2017 - "Study patients undergoing subsequent transfusion were evaluated for reported transfusion reactions and development of new alloantibodies. "
05/01/2015 - "In this study, we evaluated the frequency of alloantibodies in thalassemic patients with previous history of transfusion reactions. "
01/01/2013 - "This study was planned to detect the presence of inhibitors in our PWH and to determine the presence of transfusion transmitted infections (TTI) markers and clinically significant red cell alloantibodies in these patients. "
01/01/2012 - "This study revealed a relatively high frequency of D and a low frequency of demonstrable clinically significant alloantibodies that may cause hemolytic disease of the newborn or hemolytic transfusion reactions among pregnant women in Kampala, with anti-S being the most frequent antibody specificity."
09/30/1941 - "Studies are reported on an individual agglutinogen (Rh) in human blood which has been found to be of clinical importance because occasionally it gives rise to the formation of immune isoantibodies in man, a peculiarity which leads to untoward transfusion reactions. "