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Platelet Transfusion (Blood Platelet Transfusions)

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The transfer of blood platelets from a donor to a recipient or reinfusion to the donor.

Also Known As:

Blood Platelet Transfusions; Platelet Transfusion, Blood; Platelet Transfusions; Platelet Transfusions, Blood; Transfusion, Blood Platelet; Transfusion, Platelet; Transfusions, Blood Platelet; Transfusions, Platelet; Blood Platelet Transfusion

Networked: 1535 relevant articles (89 outcomes, 122 trials/studies)

Relationship Network

Therapy Context: Research Results

Therapeutics: 15318
- Biological Therapy: 2317
  - Blood Transfusion: 12511
    - Blood Component Transfusion: 52
      - Platelet Transfusion: 1535

Experts

1.	Murphy, Michael F: 13 articles (01/2015 - 03/2002)
2.	Slichter, Sherrill J: 13 articles (01/2015 - 07/2004)
3.	Estcourt, Lise J: 12 articles (06/2015 - 09/2010)
4.	Stanworth, Simon J: 12 articles (06/2015 - 11/2009)
5.	Stanworth, Simon: 10 articles (02/2015 - 07/2008)
6.	Heddle, Nancy M: 8 articles (11/2014 - 06/2002)
7.	Wood, Erica M: 7 articles (06/2015 - 07/2010)
8.	Doree, Carolyn: 7 articles (01/2015 - 01/2012)
9.	Rebulla, Paolo: 7 articles (01/2015 - 06/2003)
10.	Greinacher, Andreas: 7 articles (11/2014 - 05/2006)

Related Diseases

1.	Hemorrhage 11/01/2001 - "Plasmapheresis and platelet transfusions might be the best treatment in case of severe bleeding. " 02/01/1984 - "Furthermore, platelet transfusions are highly effective in thrombocytopenic bleeding." 01/01/2008 - "While no one would argue with the need for platelet transfusions in the face of severe bleeding, important questions remain about what constitutes clinically significant bleeding and whether a strategy of prophylactic platelet transfusions is effective in reducing the risk of bleeding in clinically stable patients. " 03/01/2000 - "In contrast with recent studies with low platelet yields, these data support the conclusion that platelet-rich plasma sequestration is effective in reducing allogeneic platelet transfusions and total allogeneic units transfused in cardiac surgery patients at moderately high risk for post-CPB coagulopathy and bleeding. " 02/01/2012 - "In patients at high risk for hemorrhage growth and poor outcome, early platelet transfusion improved platelet activity assay results and was associated with smaller final hemorrhage size and more independence at 3 months."
2.	Thrombocytopenia (Thrombopenia) 11/01/1992 - "Of the 2 responders with marked thrombocytopenia, 1 showed an improvement in the platelet count (7-37 x 10(9)/l) and her regular need for red cell and platelet transfusions ceased. " 08/01/2008 - "Platelet transfusion is the mainstay of treatment for severe thrombocytopenia. " 02/01/2002 - "Improved practice requires definition of a safe lower limit for platelet count in stable neonates; effective platelet transfusion strategies for sick neonates; and improved therapies for conditions precipitating severe thrombocytopenia." 10/01/2013 - "Efficacy of HLA-matched platelet transfusions for patients with hypoproliferative thrombocytopenia: a systematic review." 07/01/2012 - "Thus, we analyzed thrombocytopenia in neonates, its prevalence, and relationship if any, between clinical condition and platelet transfusion in neonates, which would have been helpful in developing guidelines and/or protocols for platelet transfusion (and reducing the donor exposure) in neonates. "
3.	Infection 05/01/1986 - "With regard to the indication of BMT, the following factors were selected as significantly favorable: young age, in remission, no infection, complete HLA-matched marrow donor, no previous radiation treatment of the brain or lung, fractionated TBI, low dose rate, platelet transfusion from anti-CMV antibody-negative donor. " 07/01/2003 - "Platelet transfusion studies demonstrate that platelet-derived CD154 alone is sufficient to induce isotype switching and augment T lymphocyte function during viral infection, leading to enhanced protection against viral rechallenge. " 05/10/2013 - "There were five bacterial transfusion transmitted infections associated with platelet transfusion reported during the study period. " 06/01/2013 - "Platelet transfusion decreased the risk of infection (p = 0.02). " 06/01/2013 - "Multivariable Cox modeling was used to assess the independent effect of blood and platelet transfusions on major infections within 60 ± 5 days of surgery. "
4.	Thrombasthenia (Glanzmann Thrombasthenia) 01/01/1979 - "[Case of Glanzmann's thrombasthenia: a familial study and confirmation of the efficacy of platelet transfusions]." 03/01/1975 - "The response to platelet transfusions was studies in two patients with Glanzmann's thrombasthenia. " 08/01/2015 - "Standard treatment for Glanzmann thrombasthenia is platelet transfusion. " 08/01/2005 - "Isoantibody against GPIIb-IIIa complexes present on normal platelets can be observed in Glanzmann's thrombasthenia type I patients after platelet transfusion possibly leading to platelet transfusion refractoriness. " 10/01/2001 - "The place of this drug compared to platelet transfusion in the overall management of patients with Glanzmann thrombasthenia will need to be determined in relationship to a number of challenges and unresolved issues in the clinical care of these patients. "
5.	Leukemia 04/01/2010 - "Therapeutic efficacy of platelet transfusion in patients with acute leukemia: an evaluation of methods." 01/01/2011 - "Our study assessed the predictive value of a flow cytometric platelet cross match test for the outcome of HLA matched and unmatched platelet transfusions in patients with acute leukemia. " 03/01/2005 - "The initial trials in leukemia or transplant settings did not impact the need for platelet transfusions. " 03/01/1997 - "We designed and conducted a randomized single-institution trial comparing two common prophylactic platelet transfusion thresholds in patients undergoing induction therapy for acute leukemia. " 03/01/1997 - "Randomized study of prophylactic platelet transfusion threshold during induction therapy for adult acute leukemia: 10,000/microL versus 20,000/microL."

Related Drugs and Biologics

1.	Anti-Bacterial Agents (Antibiotics)
2.	Antibodies
3.	recombinant FVIIa (rFVIIa)
4.	oprelvekin (Neumega)
5.	gamma-Globulins (gamma-Globulin)
6.	Interleukin-11 (Interleukin 11)
7.	Vincristine (Oncovin)
8.	Immunoglobulins (Immunoglobulin)
9.	Immunoglobulin G (IgG)
10.	Tranexamic Acid (AMCA)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Platelet Transfusion (Blood Platelet Transfusions)
3.	Transplants (Transplant)
4.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
5.	Erythrocyte Transfusion