N-acetyltalosaminuronic acid (NAT)

01/01/2015 - "Targeting of multiple virus replication steps and silencing the generation of new progeny may be of particular value for current attempts to develop novel therapeutic strategies that provide a cure or functional cure for HIV-1 infection (Nat Rev Immunol 12: 607-614, 2012). "
09/01/2001 - "Therefore, although NAT using minipools of 25 donations or less may be effective for the detection of early-stage HBV infection, it may not be effective for the detection of persistent HBV infection."
06/01/2015 - "Knowledge about the viral load (VL) distributions in different stages of hepatitis C virus (HCV) infection is essential to compare the efficacy of serologic screening and nucleic acid testing (NAT) in preventing transfusion transmission risk. "
10/01/2014 - "Nucleic acid testing (NAT) remains the gold standard for diagnosis of viremic stages of infection. "
07/01/2013 - "Nucleic acid amplification testing (NAT) for hepatitis B virus (HBV) during blood screening has helped to prevent transfusion-transmitted HBV infection (TT-HBV) in Japan. "

03/01/2013 - "Over 80% of all patients received breast-conserving therapy (BCT) after receiving NAT, and 11 of 14 (78.6%) patients with T3 tumor at diagnosis became eligible for BCT after NAT. A total of 60 patients completed ≥ 6 cycles of NAT, followed by surgery; at a median follow-up of 50 months, 80% of the patients are disease-free. "
09/01/2007 - "The efficacy of (131)I-MIBG treatment was also assessed in TMXs to determine the delay in growth of tumors composed of various proportions of NAT-expressing cells-a likely clinical scenario after gene delivery in vivo. "
01/01/2015 - "A recent study used an antibody-based approach to investigate the methylation of Lys-561 of the stress-inducible Hsp70 protein HSPA1, focusing exclusively on dimethylated HSPA1, concluding that it was elevated in cancer [Cho et al. (2012), Nat. Commun.,3, 1072]. "
01/01/2015 - "Biodistribution was investigated using AR42J tumor-bearing CD1 mice, and specificity of tracer uptake was confirmed in competition studies by coinjection of 0.8 mg TOC/kg. Sst2 affinities (IC50) of [(nat)Ga]HA-DOTATATE (1.4 ± 0.8 nM, logP: -3.16) and [(nat)Ga]DOTATATE (1.2 ± 0.6 nM, logP: -3.69) were nearly identical. "
01/01/2013 - "Second, early studies by Biedler's group indicated that the parental differentiated SK-N-SH cells contained two morphologically distinct phenotypes: neuroblast-like cells and epithelial-like cells (Ross et al., J Nat Cancer Inst 71:741-747, 1983). "

04/01/2014 - "This observational study was aimed to evaluate the morphological changes in neoplastic, nonneoplastic breast tissue and in the lymph nodes after NAT. To identify the clinical response and post operative histologic changes, this study prospectively selected 35 patients with locally advanced breast cancer treated with NAT. In these patients clinical response was assessed based on tumour size. "
02/01/2000 - "Taken together, these studies do not support a strong role for the most common NAT alleles in etiology of breast cancer. "
03/01/2015 - "A true consensus of expert opinion concerning the pathway of care appropriate for patients receiving nat for breast cancer has been achieved. "
03/01/2015 - "Consensus was achieved for all areas of the pathway of care for patients undergoing nat for breast cancer, with the exception of the role of magnetic resonance imaging in the pre-treatment or preoperative setting. "
03/01/2015 - "A modified Delphi protocol, which used iterative surveys administered to 85 experts across Canada, was established to obtain expert consensus concerning all aspects of the care pathway for patients undergoing nat for breast cancer. "

10/01/2013 - "Our analysis of viremia and infectivity of WP and EC donations enables comparison of the efficacy of NAT options in preventing HIV transmission risk."
07/01/2013 - "Testing repository samples of donations missed by minipools of 20 donations NAT showed that 75 and 85% of TT-HBV that arose from WP and OBI donations, respectively, would have been interdicted by ID-NAT. The ID-NAT trial revealed that 1.94% of donations with low anti-HBc and anti-HBs titers were viremic and that anti-HBc titers and the frequency of viremia did not correlate. "
11/01/2015 - "Strategies involving HCVAb testing in venipuncture blood, whether laboratory conducted or using a point-of-care assay, when followed by quantitative NAT done reflexively or in separately drawn blood, are comparably economical and suitably viremia sensitive. "
11/01/2015 - "Strategies adopting qualitative rather than quantitative NAT are slightly cheaper (range, $28.90-$29.99), similarly viremia specific (≥0.9997), but less viremia sensitive (≤0.9456). "
11/01/2015 - "The strategy that requires returning for NAT is even less viremia sensitive (<0.9000) because of follow-up loss. "

10/01/2010 - "Follow-up skeletal surveys have been shown to improve the rate of fracture detection in suspected cases of non-accidental trauma (NAT). "
09/01/2010 - "To determine the prevalence of parenchymal brain microhemorrhages (MHs) in infants with nonaccidental trauma (NAT) by using susceptibility-weighted (SW) magnetic resonance (MR) imaging and to assess whether the presence of MH results in improved prediction of the long-term neurologic outcome. "
06/01/2014 - "NAT was the cause of 11/342 (3.2%) spine injuries diagnosed during the study period. "
01/01/2014 - "The purpose of this study was to identify risk factors for repeated injuries in children with suspected NAT. We conducted a retrospective cohort study using claims data from a pediatric Medicaid accountable care organization. "
12/01/2006 - "During the period of study, NAT accounted for 7.3% (n = 453) of trauma evaluations (n = 6186). "