An acute hemolytic transfusion reaction due to the "anti-c" rhesus antibody: A case report emphasizing the role of transfusion medicine.

Abstract

Rhesus (Rh) mediated hemolytic transfusion reactions (HTR) are usually immunoglobulin G mediated and delayed onset. Rh antibodies being the cause of acute HTR (AHTR) and intravascular hemolysis are still under debate. We report here a case of a 53-year-old male who developed AHTR due to "anti-c" antibodies within 3 h of blood transfusion, precipitating fatal acute liver failure in a patient with hepatitis C related chronic liver disease. This case emphasizes the need of inclusion of antibody screening in routine pretransfusion testing as well as a critical role of transfusion medicine specialists for early diagnosis and minimizing transfusion-related morbidity and mortality.

• Authors: Deepti Sachan, Rajeswari Jayakumar, Joy Varghese, Mohamed Rela
• Journal: Asian journal of transfusion science (Asian J Transfus Sci) 2015 Jul-Dec Vol. 9 Issue 2 Pg. 213-5 ISSN: 0973-6247 [Print] India
• PMID: 26420949 (Publication Type: Case Reports)