Nociceptive Pain

02/01/2017 - "Unlike most current traditional opioids, it is generally more potent against neuropathic than nociceptive pain. "
12/15/2004 - "Opioid rotation was fully or partially effective in 80% and 20%, respectively, of patients with somatic pain. "
12/01/2003 - "New evidence points to efficacy of opioids for neuropathic, in addition to nociceptive pain syndromes, further clarifying the use of these agents for this patient population. "
04/10/2023 - "Our findings might suggest that autotaxin is associated with nociceptive pain processing and the regulation of opioid requirements."
01/01/2023 - "The combination of opioid use and high psychiatric comorbidity suggests that prescribers should attend to mental health in addition to somatic pain. "

01/01/2021 - "Conclusion: Most studies (27) assessed the analgesic properties of EOs on acute nociceptive pain models, e.g. "
02/01/2009 - "The present study demonstrated that PPM produced an immediate analgesic effect on deep-tissue pain indicating a possible involvement of neural inhibitory mechanisms."
02/01/2009 - "The analgesic effects of passive movements on deep-tissue pain have not been sufficiently explored in human studies. "
11/11/2004 - "Analgesic drug studies indicate this model may be useful for investigating chronic nociceptive pain."
07/01/2003 - "This study demonstrates the analgesic potential of alpha2-agonists in the horse for somatic pain and that they can have quantitatively different antinociceptive effects according to the antinociceptive test used."

01/01/2023 - "Therefore, administration of EGCG as a local anesthetic may provide relief from trigeminal nociceptive pain without side effects."
09/01/2018 - "Therefore, local injection of CGA could contribute to local anesthetic agents for the treatment of trigeminal nociceptive pain."
01/01/2018 - "Systemic administration of local anesthetics is known to be effective for various acute and chronic painful diseases, such as neuropathic pain, as well as inflammatory and nociceptive pains. "
01/01/2018 - "Quadratus Lumborum Block in contrast to Transversus Abdominis Plane Block contains a unique component which not only stops somatic pain but also inhibits visceral pain by spreading the local anesthetic to the paravertebral space. "
07/01/2011 - "Various adjuvants have been used with local anesthetics in spinal anesthesia to avoid intraoperative visceral and somatic pain and to provide prolonged postoperative analgesia. "

01/01/2021 - "The present study was to characterize the behavioural effects of KLS-13019 compared to CBD and morphine in mouse models of CIPN, nociceptive pain and reinforcement. "
01/01/2016 - "In patients receiving 2mg morphine into inflamed tissue, pain scores at rest were reduced to a similar extent in both groups at all measurement times up to 10h in the follow-up (Trial II). "
07/01/1994 - "The results of the present study demonstrated that spinal morphine was capable of suppressing the evoked activity of the viscero-somatic convergent neurons, resulting in suppression visceral and somatic pain behavioral reflexes."
07/01/1994 - "This study was undertaken to examine the role of morphine in modulation of nociception in visceral and somatic pain tests at the level of the spinal cord, using neurophysiological and behavioural reflex assays. "
10/01/2018 - "Morphine - the main pillar of nociceptive pain management - systemic use is associated with development of tolerance and dependence. "

01/01/2006 - "More than 100 articles that reflected the prevalence of somatic pain in patients with physical illness with and without comorbid depression or anxiety and that evaluated the efficacy of antidepressants in this population were identified and reviewed. "
01/01/1991 - "Despite the fact that a majority of patients treated without consultation reported disturbances of mood, appetite, and sleep, as well as somatic pain for which no source was readily apparent, only a small proportion received antidepressants in standard dosages. "
10/20/2023 - "Our findings highlight that rTMS in combination with antidepressants is a rapid method of symptom improvement in patients with somatic pain with MDD and is helpful for cognitive impairment and anxiety."
01/01/2016 - "To examine the association of neuropathic and nociceptive pain severity and interference with quality of life (QoL) in persons with spinal cord injury (SCI) who underwent a randomized controlled 12-week trial of an antidepressant to treat depression. "
01/01/2006 - "Keywords included depression, anxiety, pain, somatic, antidepressants, and paroxetine. "

04/01/2004 - "Based on criteria of evidence-based medicine, psychotherapy and/or tricyclic antidepressants seem to be the most promising treatment approaches for the functional somatic pain syndromes."
12/01/2003 - "In addition, tricyclic antidepressants may be used in order to treat the somatic pain component caused by the neuroplastic changes that take place in the central nervous system in chronic pain conditions."
09/01/2002 - "In addition, tricyclic antidepressants may be used in order to treat the somatic pain component caused by the neuroplastic changes that take place in the central nervous system in chronic pain conditions."
10/01/2001 - "Nociceptive pain can usually be controlled with nonsteroidal antiinflammatory drugs or corticosteroids, whereas neuropathic pain responds to tricyclic antidepressants or anticonvulsants. "
09/01/2006 - "Opioids should be initiated after an adequate trial of acetaminophen or nonsteroidal anti-inflammatory drugs for nociceptive pain and of tricyclic antidepressants or anticonvulsants for neuropathic pain. "

08/01/2017 - "Chances are that the treatment of nociceptive pain during movement with NSAID or COX-2-inhibitors is more successful. "
04/01/1999 - "The topical administration of non-steroidal antiinflammatory drugs (NSAIDs) is widely used for the treatment of soft tissue pain. "
01/01/2007 - "NSAIDs have anti-inflammatory effects and are particularly effective against somatic pain represented by that due to bone metastasis. "
01/01/2021 - "Although NSAID use was highest among those with nociplastic pain (80%), pain relief ratings for NSAIDs were highest among those with nociceptive pain. "
12/01/2018 - "The management of nociceptive pain requires a sequential hierarchical approach, with the initial NSAID treatment being characterized by the replacement of one drug with another, or complete discontinuation usually because of insufficient pain control. "

12/01/2018 - "The mechanisms of action of diclofenac make it particularly effective in treating both nociceptive pain and chronic central pain. "
07/01/2013 - "Both capsaicin and topical diclofenac have been shown to be effective in the treatment of patients with chronic soft-tissue pain. "
01/01/2015 - "Effects of topical diclofenac plus heparin (DHEP+H plaster) on somatic pain sensitivity in healthy subjects with a latent algogenic condition of the lower limb."
12/01/2023 - "Therefore, we hypothesized that the systemic transdermal formulation of diclofenac sodium (DF systemic patch), which is effective for nociceptive pain, and an α2δ Ca2+ channel ligand, which is effective for neuropathic pain, would have additive effects in the treatment of chronic low back pain. "
01/01/2019 - "Pain creams compounded for neuropathic pain (ketamine, gabapentin, clonidine, and lidocaine), nociceptive pain (ketoprofen, baclofen, cyclobenzaprine, and lidocaine), or mixed pain (ketamine, gabapentin, diclofenac, baclofen, cyclobenzaprine, and lidocaine), or placebo. "

09/01/2010 - "This pooled analysis shows that treatment with OROS hydromorphone had similar efficacy for neuropathic and nociceptive pain."
09/01/2010 - "A mixed model for repeated measures linear regression analysis was used to compare the effect of OROS hydromorphone on patients with neuropathic and nociceptive pain, adjusting for potentially confounding factors. "
03/03/2010 - "After an average of 43 days of treatment with controlled release hydromorphone, the intensity of momentary pain dropped by 46.5% and that of maximum pain dropped by 41.3%, with the efficacy of the treatment being most pronounced with visceral and somatic pain. "
09/01/2010 - "Secondary outcomes were the effect of OROS hydromorphone on other BPI items including "pain relief" and "interference with sleep." Patients with neuropathic pain showed a similar response to treatment with OROS hydromorphone to those patients with nociceptive pain. "
01/01/2022 - "While morphine is the gold standard treatment for severe nociceptive pain in children, hydromorphone is increasingly prescribed in this population. "

01/01/2022 - "This study investigated the role of LPA-LPA1  signaling in acute nociceptive pain using the formalin test. "
02/10/2020 - "In this study, Salvia divinorum antinociceptive activity was evaluated in experimental models of nociceptive pain; the writhing test and formalin-induced licking behavior in mice. "
01/01/2022 - "The somatic pain threshold in Scn11a R222S/R222S mice was assessed by Hargreaves' test and formalin test. "
05/10/2019 - "Similarly, PV significantly (p < 0.05) decreased nociceptive pain, studied using hot plate, tail flick, formalin and writhing tests. "
06/01/2014 - "Nociceptive pain scores observed in formalin test had the highest nociceptive sensation 5 minutes after injection. "

04/01/2023 - "Peripheral nerve stimulation (PNS) is an effective neuromodulation therapy for chronic neuropathic and nociceptive pain. "
01/01/2023 - "Although rarely studied, reporting outcomes of DRG-S to treat predominantly mechanical/nociceptive pain may help point toward expanding the utility of this therapy. "
01/01/2022 - "[Topical therapy of acute nociceptive pain: results of an open randomized clinical trial of the domestic drug Alental cream]."
02/01/2020 - "IFN-α therapy induce significant somatic pain as early as the 2nd week of treatment in HCV patients who later developed MDD. "
02/01/2020 - "Moreover, NRS somatic pain scores after initial therapy strongly correlated with NRS somatic pain scores at all other assessment time points (p ​< ​.001). "

11/08/2022 - "However, systemic analgesia does not fully prevent perioperative visceral and somatic pain triggered by the surgical stimulus. "
01/01/2017 - "Ultrasound-guided transversus ab- dominis plane (TAP) and rectus sheath (RS) blocks are peripheral nerve blocks that diminish somatic pain of the abdominal wall and are useful for postoperative analgesia. "
02/01/2016 - "It appears that this approach may achieve analgesia with lower doses in those with primary nociceptive pain type."
01/01/2011 - "There is strong evidence to support its short-term use for neuropathic and nociceptive pain, and conflicting evidence for preemptive analgesia. "
04/01/2009 - "Previous work from our lab showed that stimulation of the lateral hypothalamus (LH) produces analgesia (antinociception) in a model of thermal nociceptive pain. "

04/01/2011 - "Aortoiliac occlusive disease (AIOD) is an insidious, progressive atherosclerotic process that can lead to claudication, rest pain, tissue loss, and eventual lower extremity amputation. "
01/01/2021 - "Clinical improvement was achieved in all patients with resolution of rest pain, tissue formation of granulation tissue or both; only 3 major amputations were performed within the study period with a limb salvage rate of 78%. "
05/01/2009 - "With a mean followup of 1,089 days (range 0 to 3,689 days), overall outcomes performance declined consistently according to indication for all end points measured at 5 years (claudication, rest pain, tissue loss, p value): secondary reconstruction patency (93%, 80%, 66%, respectively; p < 0.001), limb salvage (99%, 81%, 68%, respectively; p < 0.001), survival (78%, 46%, 30%, respectively; p < 0.001), amputation-free survival (78%, 42%, 25%, respectively; p < 0.001), maintenance of ambulation (96%, 78%, 68%, respectively; p < 0.001), maintenance of independence (98%, 85%, 75%, respectively; p < 0.001), and resolution of presenting symptoms (79%, 61%, 42%, respectively; p < 0.001). "
05/01/2010 - "The Bypass versus Angioplasty in Severe Ischaemia of the Leg (BASIL) trial showed in patients with severe lower limb ischemia (rest pain, tissue loss) who survive for 2 years after intervention that initial randomization to bypass surgery, compared with balloon angioplasty, was associated with an improvement in subsequent amputation-free survival and overall survival of about 6 and 7 months, respectively. "
05/01/2010 - "The Bypass versus Angioplasty in Severe Ischaemia of the Leg (BASIL) trial showed that survival in patients with severe lower limb ischemia (rest pain, tissue loss) who survived postintervention for >2 years after initial randomization to bypass surgery (BSX) vs balloon angioplasty (BAP) was associated with an improvement in subsequent amputation-free and overall survival of about 6 and 7 months, respectively. "

10/01/2020 - "Efficacy of Physical Therapy on Nociceptive Pain Processing Alterations in Patients with Chronic Musculoskeletal Pain: A Systematic Review and Meta-analysis."
11/17/2020 - "The current narrative literature review aims to discuss clinical reasoning based on nociceptive pain mechanisms for determining the most appropriate assessment and therapeutic strategy and to identify/map the most updated scientific evidence in relation to physical therapy interventions for patients with temporomandibular disorders (TMDs). "
06/01/2019 - "The study included 99 female patients (mean age 44.21 years; range, 18 to 65 years) who referred to Physical Therapy and Rehabilitation Department Outpatient Clinics with complaints of widespread pain and who received a clinical diagnosis of fibromyalgia based on the 1990 American College of Rheumatology diagnostic criteria and a control group consisting of 86 female patients (mean age 49.21 years; range, 18 to 65 years) who were diagnosed with acute subacromial impingement as a nociceptive pain model. "
01/01/2018 - "In addition to analgesics, another option is radial extracorporeal shock wave therapy (rESWT), a novel physical therapy that has been successfully used in the treatment of many types of chronic soft tissue pain. "
03/01/2014 - "Pain content from 74 older black adults with persistent osteoarthritis pain was analyzed using criteria from the American Pain Society arthritis pain management guidelines that included type of pain (nociceptive/neuropathic), quality of pain, source, location, intensity, duration/time course, pain affect, effect on personal lifestyle, functional status, current pain treatments, use of recommended glucosamine sulfate, effectiveness of prescribed treatments, prescription analgesic side effects, weight management to ideal body weight, exercise regimen or physical therapy and/or occupational therapy, and indications for surgery. "

12/02/2022 - "The subjective pain intensity index, Western Ontario and McMaster Universities OA Index (WOMAC), and Lequesne index were used to determine the efficacy of FSN on MTrP-induced soft-tissue pain compared with that of TENS. "
05/01/1995 - "These results suggest that most of dorsal horn cells with renal inputs have the concomitant somatic inputs and TENS can alleviate the renal pain as well as somatic pain."
11/01/1986 - "However, pain resulting from internal structures, i.e., deep pain, afterbirth pain (due to uterine contractions), and the somatic pain associated with decreased peristalsis (gas pains) were not amenable to TENS. "
08/01/1997 - "If the pain is somatic, treatment options include: Somatic Pain: Treatment Isolated nerve block Continuous nerve block TENS (external) Direct electrical nerve stimulation (internal) Nerve ablation If the pain is sympathetic in origin, treatments to be considered are: Sympathetic Nerve Pain: Treatment Protection of limb (garment or splint) Combine with active use Sympathetic blocks single continuous Sympathectomy In addition, the treatment of each of those conditions must be directed at the primary condition. "
05/01/1995 - "However, most of the studies concerning the analgesic effects and their mechanisms for TENS have dealt with somatic pain. "