Visceral Pain

07/01/2015 - "The selective FAAH inhibitor and dual FAAH/MAGL inhibitors were effective in both inflammatory and mechanically evoked visceral pain, while the MAGL inhibitor elicited an analgesic effect in inflammatory, but not in distension-induced, visceral pain."
05/01/2022 - "Ultrasound-guided erector spinae plane (ESP) block has emerged as an effective and safe analgesic regional technique and it also provides visceral pain relief. "
06/01/2015 - "The method may improve our understanding of visceral pain and could be an objective method for studying efficacy of analgesics on visceral pain."
01/01/1983 - "In the second group spasmodic visceral pain was felt after about 10 hours, relieved by light analgesics. "
01/01/2022 - "Even with a low rate of complications, the model is feasible and reproducible for studies on visceral pain and the evaluation of analgesic effects."

09/01/2009 - "Peripherally selective opioids may be beneficial in visceral pain management due to absence of centrally mediated side effects. "
08/01/1995 - "Spinal combinations of alpha 2-adrenergic and mu- or delta- but not kappa-opioid agonists may be beneficial in the control of visceral pain."
01/01/2018 - "Thus, opioids that act at μ or δ receptors, or their heterodimers may be effective in treating visceral pain."
02/01/2013 - "Peripherally acting opioids, particularly peripheral κ-opioid agonists, may be effective for treating visceral pain by activating receptors expressed on afferent nerves within the gut. "
11/01/2000 - "The principal objective of this report is to review recent experimental advances in our understanding of the physiology and pathophysiology of visceral pain and to describe results of studies of opioid modulation of visceral nociception. "

02/01/2003 - "These findings and responsivity to morphine suggest the utility of this model developed in a commercially available strain of rats for study of persistent visceral pain."
01/01/1989 - "In this paper the averaged cortical evoked potential (C-CEP) induced by stimulating the C-fibers of the splanchnic nerve was used as an index of visceral pain to further study the effects of acupuncture and morphine on it. "
10/01/2021 - "Compared with the OSTAP group, the morphine doses from 6 to 12, 12 to 18, and 18 to 24 hours were significantly lower, the time of first need for morphine was significantly longer and the NRS scores for visceral pain intensity were significantly lower in the TQL group. "
01/01/2019 - "The finding revealed that the avoidance memory and visceral pain were reduced significantly in male and female offspring with at least one morphine-treated parent. "
11/01/2014 - "Predisposing effects of neonatal visceral pain on abuse-related effects of morphine in adult male Sprague Dawley rats."

03/01/2010 - "Oxycodone CR appears to be a very well tolerated and effective treatment for patients with visceral pain."
11/01/2019 - "Postoperative visceral pain is common after surgery and previous studies have demonstrated that oxycodone is an effective treatment. "
12/01/2018 - "Effect of Intravenous Oxycodone in Combination With Different Doses of Dexmedetomdine on Sleep Quality and Visceral Pain in Patients After Abdominal Surgery: A Randomized Study."
09/01/2009 - "Oxycodone exhibited a generalized effect, elevating thresholds for cutaneous, deep somatic, and visceral pain stimulation."
03/01/2010 - "This study was conducted to determine the incidence of visceral pain in patients with uncontrolled moderate-to-severe pain, and to evaluate the efficacy of controlled-release (CR) oxycodone in this context. "

09/30/2011 - "These results show that whilst both models have similar responses to gabapentin in terms of visceral pain they differ in terms of their physiological response to stress. "
09/30/2011 - "No data exists to our knowledge of the effects of gabapentin in animal models of co-morbid exaggerated stress response and visceral pain. "
01/01/2015 - "Our results showed that visceral pain behaviors in these rats decreased after intraperitoneal injection of gabapentin. "
06/01/2010 - "Here, we report that gabapentin is a good adjunct for visceral pain in a porphyria patient. "
02/01/2009 - "In conclusion, gabapentin decreased thermal, electrical, and chemogenic pain but not visceral pain and had a gastric protective effect."

02/25/2023 - "Compared with the control group, the model group had an evident increase in the levels of AWR, LF, LF/HF, ChAT protein expression, cAMP and cGMP contents and cAMP/cGMP ratio (P<0.001, P<0.05), and a marked decrease in the levels of HF, frequency of slow waves of intestinal EMG, visceral pain threshold (PT), immunoactivity and expression of TH protein (P<0.05, P<0.001). "
01/01/2020 - "Our findings demonstrate that the up-regulation of AC1 protein in the cortex may underlie the pathology of chronic visceral pain; and inhibiting AC1 activity may be beneficial for the treatment of visceral pain."
07/30/2017 - "The aim of this study was to test the expressions of Piezo1 and Piezo2 proteins in the intestinal epithelial cells from different intestinal segments and to explore the correlation between Piezo proteins expression and visceral pain threshold. "
01/01/2016 - "In the present study we investigated the impact of long-term exposure to high-fat diet on visceral pain perception and on the levels of TLR4 and Cd11b (a microglial cell marker) protein expression in the prefrontal cortex (PFC) and hippocampus. "
07/01/2003 - "In our study, Fos protein expression in retrogradely labeled STT and PSDC neurons in the lumbosacral enlargement in rats was used as an anatomical marker of enhanced activation to compare the role of these neurons in cutaneous and visceral pain. "

11/01/2019 - "Preemptive oxycodone is superior to equal dose of sufentanil to reduce visceral pain and inflammatory markers after surgery: a randomized controlled trail."
11/01/2019 - "Numerical rating scale (NRS) of visceral pain in the oxycodone group at 2 h when resting (0.5(0,2.75) vs 3(2,4), P = 0.008) and moving (0.5(0,3) vs 3(2.25,4), P = 0.015) and 4 h when moving (2(0,3) vs 3(0,4.75), P = 0.043) after surgery were significantly lower than the sufentanil group. "
09/01/2018 - "The ED50 and ED95 were calculated with a logistic regression model.ED50 and ED95 of epidural sufentanil for successful of the pain-free from visceral pain were 10.7 μg [95% confidence interval (CI): 2.4-14.4 μg) and 28.1 μg (95% CI: 19.4-44.0 μg), respectively. "
09/01/2018 - " study showed that sufentanil could be used in combination with ropivacaine for relief from somato-visceral pain in patients with scarred uterus during elective cesarean section during epidural anesthesia, and that maximized parturients' satisfaction could be achieved when the use of sufentanil with the dose between 15 μg and 20 μg for epidural anesthesia."
09/01/2018 - "The dose response of sufentanil as an adjuvant to ropivacaine in cesarean section for relief from somato-visceral pain under epidural anesthesia in parturients with scarred uterus."

05/01/1998 - "The present results provide further evidence that kappa-opioid receptor agonists significantly attenuate visceral nociception and, in conjunction with other information, suggest that a peripherally restricted kappa-opioid receptor agonist would be therapeutically effective in relieving visceral pain."
05/01/1998 - "The objective of this study was to evaluate the effects of kappa-opioid receptor agonists on pressor and visceromotor responses to colorectal distension in awake, unrestrained rats, a model of visceral pain. "
03/01/2009 - "Kappa-opioid receptors are located on visceral pain fibres. "
08/01/2004 - "Modulation of the function of kappa-receptors may be a novel approach to control visceral pain in functional gut disorders. "
11/01/2000 - "All pelvic nerve fibers innervating the descending colon can be sensitized and contribute to visceral pain; their responses are modulated by kappa-opioid receptor agonists acting in the periphery."

06/01/2000 - "To assess whether these agents have a role in the treatment of visceral pain, the present study examined the effects of intravenous lidocaine on neuronal and reflex responses to colorectal distension. "
07/03/2023 - "Lidocaine infusion for malignant visceral pain: case report."
08/01/2018 - "The rats exhibiting visceral pain-depressive behaviors underwent lidocaine injection in the VTA to explore the relationship between VTA and visceral pain. "
07/03/2023 - "Lidocaine infusions may be beneficial for pain management in patients with malignant bowel obstruction and visceral pain. "
11/01/2022 - "Intravenous lidocaine is superior to intraperitoneal lidocaine instillation and placebo in reducing postoperative analgesic requirement and visceral pain within the first six hours. "

10/01/2021 - "This study was undertaken to assess the modulating effects of (1) pre-exposure to repeated social disruption and (2) group testing on writhing associated with visceral pain induced by intraperitoneal administration of acetic acid. "
01/01/2020 - "In this study, we evaluated the antalgic effect of DEX on acetic acid-induced acute inflammatory visceral pain (AIVP) in rats. "
01/01/2014 - "The acetic acid induced writhing test was employed to study visceral pain. "
11/01/2009 - "The primary purpose of the present study was to assess the antinociceptive effects of these other prevalent phytocannabinoids in the acetic acid stretching test, a rodent visceral pain model. "
01/01/2005 - "In the present study, we now demonstrate that a water-soluble subfraction of BV (BVA) reproduces the antinociceptive effect of BV in acetic acid-induced visceral pain model. "

07/01/2004 - "Visceral pain syndromes, including IBS, may be effectively treated by a variety of therapies that modulate the interactions between the central and enteric nervous systems. "
01/01/2019 - "Deciphering the complex interactions between visceral afferent neurons and the gut microbiota may lead to the development of improved probiotic therapies for visceral pain."
01/01/2021 - "Although further investigations are needed to study the underlying mechanisms, CA IV inhibitors are promising candidates in the search for therapies to relieve visceral pain in IBDs."
10/01/2020 - "Despite the prevalence of visceral pain, the application of neuromodulation therapies, a standard approach for other painful conditions, has received far too little attention, despite promising outcomes from uncontrolled trials. "
01/01/2019 - "GES as a potential therapy for treating visceral pain may be explored in clinical studies."

08/01/2010 - "The large-diameter (A) fibers of ION are not the major afferent fibers affecting EA-ST 2 induced analgesia in visceral pain rats; and somatic sensory afferents from orofacial areas and visceral pain input converge in the NTS and PTN, which may be the basis of the EA analgesia in the present study."
10/22/2019 - "Multiparas aged under 30 years may be more prone to experiencing postoperative inadequate analgesia on visceral pain. "
10/22/2019 - "In patients aged < 30 years, inadequate analgesia on visceral pain was higher in multiparas than in primiparas (RR, 3.56 [1.05 to 12.04], P = 0.025). "
10/22/2019 - "Postoperative incision and visceral pain intensity were evaluated using the visual analogue scale, and inadequate analgesia was defined as a visual analogue scale score ≥ 40 during 48 h post-operation. "
03/01/2015 - "Understanding the neural circuitry of placebo analgesia in the context of visceral pain is increasingly important given evidence of clinical benefit of placebo treatment in IBS. "

01/01/2022 - "First, we observed the effect of electroacupuncture at ST25 on the visceral pain threshold and slow-wave discharge of the colon in IBS model rats. "
01/01/2022 - "The results show that nanocomponents can effectively relieve visceral pain under the action of electroacupuncture. "
01/01/2022 - "Electroacupuncture is a relatively new technique that helps relieve visceral pain by improving blood circulation and providing energy to clogged parts of the body. "
01/01/2018 - "Electroacupuncture (EA) is an efficacious treatment for alleviating visceral pain, but the underlining mechanisms are not fully understood. "
01/01/2017 - "Existing research on the neurological mechanism of electroacupuncture (EA) in the treatment of GI visceral pain has primarily been concerned with the regulation of relevant transduction pathways. "

08/01/1995 - "This study demonstrates that visceral pain accounts for most of the pain experienced after laparoscopic cholecystectomy. "
01/01/2020 - "Pain after single-incision laparoscopic cholecystectomy (SILC), especially visceral pain, often troubles patients and doctors. "
11/01/2014 - "The risk of chronic pain after laparoscopic cholecystectomy is relatively low, but significantly related to the visceral pain response during the first postoperative week."
11/01/2014 - "Early visceral pain predicts chronic pain after laparoscopic cholecystectomy."
10/01/2006 - "The findings showed that 78.33% of the patients had visceral pain, 70% experienced parietal, and 23.33% reported shoulder pain after laparoscopic cholecystectomy. "

09/01/2015 - "Cordotomy has been used effectively in the treatment of visceral pain but comes with a high risk of damaging motor and sensory pathways due to close proximity of lesion. "
02/01/2022 - "Spinal cord stimulation (SCS), intrathecal drug delivery systems (IDDS), and cordotomy have also been used successfully in patients requiring advanced options, such as those with significant spinal, ischemic, or visceral pain."
03/01/1987 - "For example, cordotomy may be helpful for unilateral pain below the waist in patients with somatic and visceral pain. "
02/01/2018 - "This article summarizes several of these neurosurgical procedures: percutaneous cordotomy for unilateral pain, punctuate midline myelotomy for visceral pain and stereotactic cingulotomy for diffuse pain syndromes. "