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Neurologic Manifestations (Neurological Manifestations)

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Clinical signs and symptoms caused by nervous system injury or dysfunction.

Also Known As:

Neurological Manifestations; Neurologic Signs; Neurologic Deficit; Focal Neurologic Deficits; Manifestations, Neurologic; Manifestations, Neurological; Neurologic Dysfunction; Neurologic Findings; Neurologic Manifestation; Neurologic Symptoms; Deficit, Focal Neurologic; Deficit, Neurologic; Deficits, Focal Neurologic; Deficits, Neurologic; Dysfunction, Neurologic; Dysfunctions, Neurologic; Finding, Neurologic; Findings, Neurologic; Focal Neurologic Deficit; Manifestation, Neurologic; Manifestation, Neurological; Neurologic Deficit, Focal; Neurologic Deficits, Focal; Neurologic Dysfunctions; Neurologic Finding; Neurologic Sign; Neurologic Symptom; Neurological Manifestation; Sign, Neurologic; Signs, Neurologic; Symptom, Neurologic; Symptoms, Neurologic; Neurologic Deficits; Neurologic Signs and Symptoms

Networked: 4205 relevant articles (320 outcomes, 221 trials/studies)

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Disease Context: Research Results

Related Diseases

1.	Stroke (Strokes)
2.	Pain (Aches)
3.	Neoplasms (Cancer)
4.	Infection
5.	Neurologic Manifestations (Neurological Manifestations)

Experts

1.	Kochanek, Patrick M: 8 articles (11/2015 - 01/2002)
2.	Torres, R J: 8 articles (11/2015 - 04/2000)
3.	Puig, J G: 8 articles (11/2015 - 04/2000)
4.	Hebl, James R: 8 articles (09/2015 - 03/2006)
5.	Hadjivassiliou, Marios: 8 articles (01/2015 - 04/2007)
6.	Kumar, Neeraj: 8 articles (01/2014 - 12/2003)
7.	Lennon, Vanda A: 7 articles (11/2014 - 07/2005)
8.	Pittock, Sean J: 7 articles (11/2014 - 07/2005)
9.	Xiong, Lize: 7 articles (01/2014 - 01/2003)
10.	Tisherman, Samuel A: 7 articles (09/2013 - 01/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Neurologic Manifestations:

1.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 05/01/1996 - "Uncertainty as to the patholophysiologic processes leading to development of neurologic symptoms, particularly in patients with systemic lupus, and difficulty in following response to clinical trials objectively have been associated with a relative lack of information about the efficacy of cyclophosphamide therapy. " 10/01/2012 - "The effect of artificial acidification of the intestinal content on neurological manifestations of acute severe cyclophosphamide intoxication was studied in rats. " 04/01/2012 - "Neurological manifestations of Behçet's disease: evaluation of 40 patients treated by cyclophosphamide." 07/01/2002 - "Acute neurologic symptoms relented immediately after cyclophosphamide pulse therapy. " 01/01/1997 - "Cyclophosphamide and steroid therapy succeeded in improving her neurologic symptoms as well as retarding the deterioration in renal function. "
2.	Adrenal Cortex Hormones (Corticosteroids)IBA 07/01/2011 - "Treatment with prolonged, high-dose corticosteroids was undertaken, and although the patient's symptoms improved, he continues to have significant neurologic deficits 8 months after surgery. " 01/01/1999 - "In the authors' experience, corticosteroids have been helpful in severe cases to relieve intracranial pressure as well as neurologic symptoms due to inflammatory responses to migrating and eventually dying worms." 05/01/1998 - "A total of 55% of patients with persistent neurologic dysfunction despite corticosteroids improved, for a duration of 2.5 months (86% of the further lifespan). " 08/01/2014 - "The routine use of corticosteroids in patients without neurologic symptoms is not necessary. " 02/01/2014 - "All neurological manifestations were associated with increased use of corticosteroids and immunosuppressive drugs (p<0.05). "
3.	Intravenous Immunoglobulins (IVIG)FDA Link 12/14/2004 - "Both groups improved, but the authors observed no significant difference between IVIg and placebo patients regarding the primary endpoint, the mean change in the Z-score of the individually chosen targeted neurologic deficit (the most affected system) from baseline to 12 weeks (p = 0.89). " 04/01/2003 - "We tried IVIg therapy again and his neurologic symptoms were markedly improved. " 01/01/2014 - "The mechanisms underlying the development of neurologic symptoms following vaccination are difficult to determine; however, providing immediate immunological treatment, such as IVIg, is effective and beneficial in countering these symptoms. " 01/15/2014 - "IVIG significantly suppressed the progression of neurologic signs and sciatic nerve conduction velocity with the inhibition of inflammatory cell infiltration, mainly of macrophages, to the peripheral nerves. " 08/15/2007 - "Speculations that IVIG might be able to reverse fixed neurologic deficits from MS could not be confirmed. "
4.	Immunoglobulins (Immunoglobulin)IBA 05/01/2002 - "Twenty-six of the 120 patients were given intravenous immunoglobulin (400 mg/kg per day for 5 days), and 21 patients (80.8%) had significant improvement in the neurologic deficit at the end of 4 weeks of therapy. " 12/01/2013 - "After steroid and IV immunoglobulin treatment, neurologic symptoms were improved. " 06/01/2010 - "He was treated with intravenous immunoglobulin and his neurologic deficits were gradually improved." 04/01/2004 - "Periodic treatment with intravenous immunoglobulin has alleviated her neurologic symptoms. " 10/01/2001 - "Treatment with i.v. immunoglobulin (400 mg/kg/day x 5 days) led to rapid partial resolution of his neurologic manifestations, but complete recovery was not obtained until 6 months later. "
5.	Vitamin E FDA LinkGeneric 09/15/2011 - "Low serum concentrations of vitamin E (≤ 2 mg/L) were detected in 3 index case horses and 16 of 17 randomly selected horses (13/14 affected and 3/3 unaffected) during study year 1. Dietary vitamin E supplementation did not improve neurologic deficits in affected horses; vitamin E administration in pregnant mares appeared to decrease but not prevent disease development among offspring born the following year. " 06/01/2005 - "Neurological manifestations in celiacs and vitamin E status." 02/01/2005 - "A gluten-free diet and vitamin E supplementation reversed both the clinical neurological manifestations and the abnormalities in the muscle biopsy. " 12/15/1995 - "Children deficient in vitamin E have various neurologic symptoms. " 01/01/1990 - "Vitamin E and neurologic deficits."
6.	AntibodiesIBA 11/01/2015 - "Secondary analysis investigated the correlations between the presence of autoimmune antibodies and sample demographics and neurological manifestations. " 10/22/2013 - "GABABR antibodies were not detected in serum of 116 patients with SCLC without neurologic symptoms. " 11/01/2012 - "These cases, as well as the reports in the literature, suggest that PE could be a useful adjunctive therapy for patients with VGKC antibodies and neurologic symptoms." 05/01/2012 - "Neurological manifestations present in patients with coexisting SOX1 antibodies and well-characterized antineuronal antibodies do not differ from those previously described in patients positive for antineuronal antibodies but no SOX1-specific anti-glial antibodies." 01/01/2011 - "HE describes patients with various neurological manifestations with elevated titres of antithyroid antibodies. "
7.	Anti-Bacterial Agents (Antibiotics)IBA 05/01/2013 - "The neurologic deficits continued improvement after he completed 8 weeks of intravenous antibiotics. " 09/01/2011 - "After draining the purulent material and completing a course of tailored antibiotics, the patient showed improvement of his neurologic deficit. " 02/01/2013 - "Documented data included demographics, cultured bacteria, immune status, sinuses involved, type of intracranial complication, otolaryngologic surgical and neurosurgical intervention, type and duration of antibiotics used, and resulting neurologic deficits. " 01/01/2011 - "Patients with significant neurologic symptoms and positive testing for Borrelia burgdorferi were treated with intravenous antibiotics, and biweekly evaluation of symptom severity was performed using a six-level ordinal scale. " 12/01/2006 - "Because of lack of neurologic deficit, we treated her with halo-fixation together with appropriate antibiotics administration. "
8.	Methylprednisolone FDA LinkGeneric 09/01/2009 - "On the basis of these results, the patient was diagnosed with diabetic lumbosacral radiculoplexus neuropathy and was treated with weekly intravenous methylprednisolone with marked improvement of neurologic symptoms and signs. " 07/01/2011 - "The patient was treated with high-dose methylprednisolone with respiratory assistance in the intensive care unit for 9 days and his neurologic symptoms improved remarkably. " 08/01/1993 - "Methylprednisolone pulse therapy led to some improvement in his neurologic dysfunctions. " 08/01/2006 - "In case of persistent tceMEP/SSEP amplitude loss, consider delaying potentially harmful interventions, such as premature termination of the procedure or methylprednisolone infusion, until a new neurologic deficit is verified with an awake-clinical examination." 12/15/2001 - "Despite much work having been done, the only treatment to date known to ameliorate neurologic dysfunction that occurs at or below the level of neurologic injury has been intravenous methylprednisolone therapy. "
9.	Prednisolone (Predate)FDA LinkGeneric 07/01/1994 - "The administration of prednisolone resulted in marked improvement in her neurologic symptoms in two months. " 06/01/2000 - "Treatment with prednisolone 40 mg per day improved and stabilized neurologic symptoms. " 09/01/2011 - "After 3.5 years of maintenance treatment with prednisolone, the bird was presented subsequent to a 5-hour episode of obtunded mentation and worsening neurologic signs. " 08/18/2007 - "After operation he received neuro nutrition drugs and Prednisolone because of neurologic deficit. " 10/01/2000 - "He was treated with 60 mg of prednisolone per day, which brought about a satisfactory improvement of the above rheumatic and neurologic signs. "
10.	Thyrotropin-Releasing Hormone (Protirelin)FDA Link 12/01/2004 - "Her neurologic findings markedly improved after treatment of daily injection of thyrotropin-releasing hormone tartrate without any adverse effects. " 03/01/1989 - "We report a 9-year-old girl with cerebellar ataxia in whom the administration of thyrotropin-releasing hormone was effective in the treatment of a prolonged neurologic deficit. " 12/20/2002 - "Thyrotropin-releasing hormone (TRH) and some of its stable analogues have been shown to improve neurologic dysfunctions such as brain trauma in both animals and humans. " 04/09/1999 - "Thyrotropin-releasing hormone (TRH) and some of its stable analogues have recently been shown to improve functional recovery after neurologic dysfunctions, such as brain trauma and epilepsy, in both animals and humans. " 01/01/2000 - "To investigate the chronic effects of a novel thyrotropin-releasing hormone analog, JTP-2942 (N(alpha)-[(1S, 2R)-2-methyl-4-oxocyclopentylcarbonyl]-L-histidyl-L-prolinamide monohydrate), on behavioral changes after stroke, the authors examined its effects on motor and neurologic deficits using a middle cerebral artery (MCA) occlusion model in rats. "

Therapies and Procedures

1.	Decompression 09/01/1989 - "The patients with gross vertebral destruction and greater than 50% collapse of the vertebral body, those in need of a tissue diagnosis, or those with major neurologic deficit can be effectively treated by anterior decompression and stabilization." 01/15/2008 - "Decompression followed by the instrumented fusion of the thoracic spine was effective for improving the neurologic symptoms." 10/01/1997 - "Many studies indicate that spinal canal decompression and stabilization lead to improved neurologic recovery in patients with incomplete neurologic deficits. " 09/01/2012 - "After decompression, the neurologic deficit was relieved. " 04/20/2007 - "After spinal decompression, neurologic symptoms improved completely in 2 weeks. "
2.	Aftercare (After-Treatment) 05/01/2013 - "Suspected positive cases (n = 6) had neurologic deficits consistent with EPM, marked improvement after treatment, and exclusion of other diseases. " 06/01/1999 - "In this study, two out of three patients improved after treatment of the neurologic deficit." 09/15/2006 - "Fifteen patients had a primary neurologic deficit, which improved markedly in 11 cases after treatment. " 02/01/2001 - "Two years after treatment, the preoperative neurologic deficit had improved except for weakness of muscles innervated by the C8 nerve root. " 11/01/2015 - "Progression was detected in 3 patients at 0.3, 0.9, and 2.5 years after treatment, respectively, with progressive neurologic symptoms. "
3.	Drug Therapy (Chemotherapy) 03/01/2000 - "Neurologic symptoms improved dramatically after chemotherapy started. " 02/01/2005 - "After four courses of the same chemotherapy, she again had a complete response, confirmed by cranial enhanced magnetic resonance imaging (MRI), and she felt well, with relief from the debilitating neurologic symptoms for 4 months. " 04/01/2003 - "Antihelminthic chemotherapy yielded marked improvement of the neurologic deficits and cerebral lesions. " 08/01/2015 - "For BICAO patients who are with mild neurologic deficits and good cerebral collateral and metabolism, the timely administration of pharmacotherapy might be safe and effective. " 11/01/2012 - "The patient was subsequently treated with chemotherapy and neurologic symptoms gradually improved."
4.	Radiotherapy 02/01/2006 - "Radiotherapy was effective in treating neurologic deficit in five patients. " 09/07/2007 - "The metastatic lesions almost completely disappeared after whole-brain radiotherapy with a total dose of 50 Gy. Neurologic symptoms decreased, and the patient's quality of life improved. " 06/01/2014 - "Surgery was indicated if the neurologic deficit was severe or developed quickly or if the radiotherapy was not effective. " 06/01/2014 - "Radiotherapy was usually our first choice if the neurologic deficit was mild or developed slowly. " 01/01/2014 - "Patients radiated within 2 weeks post-surgery were more likely to have older age (p = 0.03), treated with 2D techniques (p < 0.001) and dose <36 Gy (p < 0.001), undergo a biopsy only (p < 0.001), KPS of <70 (p < 0.001), severe pre-radiotherapy neurologic symptoms (p = 0.04), and bilateral disease (p = 0.02). "
5.	Surgical Decompression 04/01/2008 - "After surgical decompression and corticosteroid pulse therapy, the patient's neurologic symptoms improved dramatically. " 09/01/2000 - "Reported here are the results after a long-term followup of four patients with hydatid disease of the spine with neurologic deficit which significantly improved after anterior surgical decompression and anthelmintic therapy. " 03/01/2010 - "Surgical decompression was performed on the second postoperative day of bypass surgery, and neurologic deficits gradually improved." 01/15/2010 - "The patient responded well to decompression surgical treatment and has since then exhibited no neurologic deficits. " 10/01/1986 - "These findings, supported by previous reports of autopsy specimens, may explain in part: the frequent discrepancy between the levels of maximal cervical compression and the variable neurologic signs; and the frequent lack of improvement in clinical signs after surgical decompression of the spinal cord at this late stage of the illness. "