Abstract | OBJECTIVE: DATA SOURCES: MEDLINE and PsychLIT/PsycINFO database. Keywords included depression, anxiety, pain, somatic, antidepressants, and paroxetine. Only English-language publications and abstracts were considered. STUDY SELECTION: More than 100 articles that reflected the prevalence of somatic pain in patients with physical illness with and without comorbid depression or anxiety and that evaluated the efficacy of antidepressants in this population were identified and reviewed. DATA SYNTHESIS: CONCLUSIONS: The efficacy of paroxetine for depression and anxiety comorbid with physical illness looks promising. Studies also allude to evidence linking the analgesic properties of paroxetine with its serotonergic and noradrenergic activity. Large randomized controlled trials within specific antidepressant classes and also comparing dualaction antidepressants are warranted that could shed some light on the unique advantage of paroxetine over other antidepressants.
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Authors | Prakash S Masand, Meera Narasimhan, Ashwin A Patkar |
Journal | Primary care companion to the Journal of clinical psychiatry
(Prim Care Companion J Clin Psychiatry)
Vol. 8
Issue 3
Pg. 122-30
( 2006)
ISSN: 1523-5998 [Print] United States |
PMID | 16912814
(Publication Type: Journal Article)
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