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Diclofenac (SR 38)

A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.

Also Known As:

SR 38; Voltaren; Diclofenac Sodium; Voltarol; SR38; Dichlofenal; Diclofenac Potassium; Diclonate P; Dicrofenac; Feloran; GP-45,840; Novapirina; Orthofen; Orthophen; Ortofen; SR-38; Sodium Diclofenac; Diclofenac, Sodium; GP 45,840; GP45,840; Diclophenac; Benzeneacetic acid, 2-((2,6-dichlorophenyl)amino)-

Networked: 2961 relevant articles (452 outcomes, 688 trials/studies)

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Drug Context: Research Results

Experts

1.	Laine, Loren: 12 articles (12/2012 - 04/2002)
2.	Gold, Morris S: 11 articles (01/2013 - 01/2003)
3.	Curtis, Sean P: 10 articles (12/2012 - 08/2006)
4.	Moore, R Andrew: 9 articles (01/2015 - 01/2009)
5.	Derry, Sheena: 8 articles (01/2015 - 01/2009)
6.	Ortiz, Mario I: 8 articles (10/2014 - 02/2002)
7.	Kaur, Amarjot: 8 articles (12/2012 - 11/2006)
8.	Cannon, Christopher P: 8 articles (12/2012 - 08/2006)
9.	Roth, Joachim: 7 articles (06/2015 - 01/2002)
10.	Varas-Lorenzo, Cristina: 7 articles (03/2014 - 03/2006)

Related Diseases

1.	Pain (Aches) 05/01/1991 - "Physician's assessment of complete relief of pain was also statistically significant (P less than 0.01) in favour of Voltaren Emulgel throughout the trial period and the physician's overall assessment of therapeutic efficacy revealed that a satisfactory result was achieved in 86% of Voltaren Emulgel-treated patients compared with 76% of patients receiving regular gel (P less than 0.05). " 01/01/2015 - "The diclofenac group displayed a more marked decrease in the pain score than did the two other groups by day 30. " 07/01/2010 - "Diclofenac is a proven, commonly prescribed nonsteroidal anti-inflammatory drug (NSAID) that has analgesic, anti-inflammatory, and antipyretic properties, and has been shown to be effective in treating a variety of acute and chronic pain and inflammatory conditions. " 05/01/1999 - "Diclofenac-potassium is a potent NSAID available as a fast-acting oral tablet, which has been shown to be safe and effective in several other acute pain indications. " 01/01/2008 - "* Single-dose HPbetaCD diclofenac 3.75, 9.4, 18.75, 25, 37.5, 50 and 75 mg administered by intravenous bolus injection produced significantly greater responses than placebo for total pain relief (TOTPAR) over 6 hours or pain intensity at 4 hours in the treatment of moderate or severe postoperative dental pain in randomized, double-blind trials. "
2.	Osteoarthritis 11/20/2004 - "Acupuncture plus diclofenac is more effective than placebo acupuncture plus diclofenac for the symptomatic treatment of osteoarthritis of the knee." 01/01/2012 - "A comparison of the therapeutic efficacy of diclofenac in osteoarthritis: a systematic review of randomised controlled trials." 01/01/1991 - "The results of this 4-week study thus demonstrate that diclofenac dispersible is not only effective in treating osteoarthritis in the elderly but also has an acceptable tolerability profile in a patient population which is especially vulnerable to adverse effects induced by non-steroidal anti-inflammatory drugs." 09/01/1996 - "Effective treatment of osteoarthritis with a 150 mg prolonged-release of diclofenac sodium." 04/28/1986 - "The results of this review document that diclofenac is as effective as other nonsteroidal anti-inflammatory drugs in the treatment of osteoarthritis."
3.	Postoperative Pain 04/01/2011 - "Administration of a single drop of topical diclofenac 0.1% 2 hours before PRK seemed to increase the efficacy of postoperative pain management in a clinically and statistically significant manner. " 01/01/2015 - "The objective of this open-label, randomized, parallel group, active-controlled study was to assess the safety and efficacy of 75 mg diclofenac HPβCD, administered SC or IM, compared with IM Voltaren® 75 mg in inpatients undergoing minor orthopedic surgeries with moderate-to-severe postoperative pain. " 01/01/1987 - "Efficacy of diclofenac in a single prophylactic dose in postoperative pain." 12/01/1991 - "A randomised, controlled study was undertaken to assess the postoperative pain and side effects experienced by patients undergoing day case diagnostic laparoscopy and laparoscopic sterilisation, and to evaluate the effectiveness in these patients of peroperative diclofenac. " 08/01/1985 - "The study indicates that visual analogue scales may also be useful in assessment of swelling and that Voltaren in a fixed dosage offers a promising alternative against postoperative pain and swelling."
4.	Rheumatoid Arthritis 01/01/1986 - "Diclofenac was found to be effective, safe, and well tolerated for the treatment of patients with active rheumatoid arthritis." 01/01/2008 - "Enhanced efficacy of diclofenac sodium-loaded lipogelosome formulation in intra-articular treatment of rheumatoid arthritis." 01/01/1988 - "Comparative pharmacokinetic and pharmacodynamic studies on ortophen, a new Soviet antiinflammatory drug, and voltaren (Ciba-Geigy, Switzerland) were carried out in 73 patients with rheumatoid arthritis. " 01/01/1986 - "Double-blind randomized trial of diclofenac sodium versus placebo in patients with rheumatoid arthritis." 01/01/1978 - "A study of the anti-inflammatory effect of Voltaren in patients with rheumatoid arthritis."
5.	Inflammation 08/01/2003 - "This was a randomized, double-blind, placebo-controlled study designed to compare the antihyperalgesic efficacy of topical (65 mg) and oral (93 mg) diclofenac via estimates of mechanical pain thresholds obtained at the site of induced inflammation with von Frey hairs. " 01/01/1986 - "A useful model that combines paracentesis with administration of a leukotactic factor was developed in order to study the effects of topical diclofenac sodium on various aspects of ocular inflammation. " 07/15/2015 - "Coadministration of diclofenac sodium can reduce the inflammatory response to BMP-2 without impairing heterotopic bone formation in our rodent model of BMP-2-induced inflammation. " 07/15/2015 - "To evaluate the effects of the coadministration of the nonsteroidal anti-inflammatory drug, diclofenac, on BMP-induced inflammation using our rodent model. " 07/15/2015 - "Effects of Diclofenac Sodium on BMP-induced Inflammation in a Rodent Model."

Related Drugs and Biologics

1.	Acetaminophen (Paracetamol)
2.	Diclofenac (SR 38)
3.	Naproxen (Naprosyn)
4.	Ibuprofen (Motrin)
5.	Indomethacin (Indometacin)
6.	celecoxib (Celebrex)
7.	Piroxicam (Feldene)
8.	Aspirin (Acetylsalicylic Acid)
9.	Ketorolac
10.	Ketoprofen (Orudis)

Related Therapies and Procedures

1.	Analgesia
2.	Phacoemulsification
3.	Intramuscular Injections
4.	Transdermal Patch
5.	Injections