Osteopontin

A negatively-charged extracellular matrix protein that plays a role in the regulation of BONE metabolism and a variety of other biological functions. Cell signaling by osteopontin may occur through a cell adhesion sequence that recognizes INTEGRIN ALPHA-V BETA-3.

Also Known As:

Networked: 2458 relevant articles (52 outcomes, 299 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Uede, Toshimitsu: 48 articles (06/2015 - 01/2002)
2.	Denhardt, David T: 41 articles (10/2013 - 03/2002)
3.	Chambers, Ann F: 31 articles (01/2015 - 01/2002)
4.	Kuo, Paul C: 29 articles (01/2016 - 12/2003)
5.	Rittling, Susan R: 25 articles (01/2011 - 03/2002)
6.	Kon, Shigeyuki: 24 articles (01/2014 - 01/2002)
7.	Mi, Zhiyong: 23 articles (01/2016 - 09/2004)
8.	Guo, Hongtao: 21 articles (02/2012 - 12/2003)
9.	Kundu, Gopal C: 19 articles (08/2014 - 04/2003)
10.	Tuck, Alan B: 18 articles (01/2015 - 02/2003)

Related Diseases

1.	Neoplasms (Cancer) 02/15/2006 - "Patients with both S100A4-positive and osteopontin-positive primary tumors showed a statistically significant reduction in survival time over those with either one alone (P < 0.019), although in multivariate regression analysis, only staining for S100A4 was significant (P < 0.001). " 04/10/2015 - "Recent studies have shown that OPN (osteopontin) plays critical roles in cell survival, differentiation, bio-mineralization, cancer and cardiovascular remodeling. " 01/01/2015 - "Previous studies have investigated the association between osteopontin (OPN) gene polymorphisms, rs17524488 (-156 GG/G), rs11730582 (-443 T/C), and rs9138 (C/A) and cancer risk in the Chinese population. " 01/01/2015 - "Several studies have been conducted to examine the associations between osteopontin (OPN) promoter gene SPP1 polymorphisms with human cancers in Chinese population, but the results remain inconsistent. " 11/15/2014 - "In this study, we found that osteopontin expressed by tumor cells enhances extramedullary myelopoiesis in a CD44-dependent manner through the Erk1/2-MAPK pathway. "
2.	Inflammation 12/01/2012 - "Osteopontin (OPN) plays an important role in the initiation of inflammation, affecting cell adhesion, chemotaxis, immune regulation, and protection against apoptosis, depending on its intracellular or extracellular localization. " 08/01/2008 - "Aim of the study was to investigate the expression of OPN (osteopontin) and its upper-downstream regulating factors in the biliary atretic liver and explore the relationship to progressive intrahepatic fibro-inflammation. " 02/01/2004 - "To examine the expression and localization of osteopontin (OPN), a secreted phosphoprotein implicated in the development of tubulointerstitial inflammation in various models of renal disease, in human diabetic kidneys, and to study the regulation of OPN expression in primary cultures of human renal proximal tubular epithelial cells (RPTEC). " 12/01/2015 - "A correlation between osteopontin expression and a high degree of inflammation was found. " 10/01/2015 - "Osteopontin is a multifunctional cytokine that can modulate a variety of cellular activities, such as fibrotic response and inflammation. "
3.	Neoplasm Metastasis (Metastasis) 12/15/2004 - "Understanding the molecular mechanisms that underlie regulation of transcription of the human osteopontin encoding gene (OPN) may help to clarify several processes, such as fibrotic evolution of organ damage, tumorigenesis and metastasis, and immune response, in which OPN overexpression is observed. " 03/01/2014 - "In this review, we summarize the novel findings from our series of studies on the leading metastasis-related gene, osteopontin (OPN). " 01/01/2014 - "This study explored whether genetic variations in the osteopontin gene are associated with ICC risk, progression and metastasis. " 11/01/2011 - "Studies indicate overexpression of osteopontin (OPN) promotes carcinogenesis, progression and metastasis of multiple human malignancies. " 10/01/2014 - "Osteopontin (OPN) is a secreted phosphorylated and glycosylated protein, which plays an important role in carcinogenesis and metastasis. "
4.	Breast Neoplasms (Breast Cancer) 12/01/2013 - "The expression of osteopontin-c was an independent prognostic factor for both disease-free and overall survival of breast cancer patients. " 01/01/2014 - "Assessment of osteopontin in early breast cancer: correlative study in a randomised clinical trial." 06/01/2013 - " this study osteopontin is presented as a possible candidate for a breast cancer biomarker. " 07/01/2008 - "Osteopontin expression according to molecular profile of invasive breast cancer: a clinicopathological and immunohistochemical study." 06/01/2006 - "This is the first study to show that in women with metastatic breast cancer, increases in osteopontin levels over time are strongly associated with poor survival. "
5.	Fibrosis (Cirrhosis) 09/01/2014 - "Being a human study, there was no control group, so it is not possible to determine the contribution of osteopontin in the formation of epidural fibrosis and its relation to the patients' symptoms. " 11/01/2012 - "Our previous study found that osteopontin (OPN) increased in plasma of cirrhotic patients and indicative of cirrhosis staging. " 09/01/2005 - "To study the fibrosis-relevant effects of osteopontin we stimulated primary human lung fibroblasts and alveolar epithelial cells (A549) with recombinant osteopontin. " 06/01/2004 - "Recent gene microarray studies found that osteopontin is abundantly expressed in both human and mouse lung fibrosis. " 08/21/2015 - "Osteopontin (OPN) is a multifunctional cytokine critically involved in cardiac fibrosis. "

Related Drugs and Biologics

1.	Osteoprotegerin
2.	Interferons
3.	Cytokines
4.	Proteins (Proteins, Gene)
5.	Integrin-Binding Sialoprotein
6.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
7.	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)
8.	Transforming Growth Factor beta (TGF-beta)
9.	Tissue Inhibitor of Metalloproteinase-1
10.	Transforming Growth Factor beta1 (TGF beta 1)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Radiotherapy
3.	Aftercare (After-Treatment)
4.	Ligation
5.	Angioplasty (Angioplasty, Transluminal)