Interferons

Proteins secreted by vertebrate cells in response to a wide variety of inducers. They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions.

Also Known As:

Networked: 24941 relevant articles (2029 outcomes, 3054 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kumada, Hiromitsu: 89 articles (11/2015 - 01/2002)
2.	Zeuzem, Stefan: 75 articles (01/2016 - 10/2002)
3.	Chayama, Kazuaki: 72 articles (11/2015 - 01/2002)
4.	Suzuki, Fumitaka: 67 articles (10/2015 - 01/2002)
5.	Ikeda, Kenji: 62 articles (10/2015 - 01/2002)
6.	Suzuki, Yoshiyuki: 62 articles (07/2015 - 01/2002)
7.	Akuta, Norio: 62 articles (02/2015 - 01/2002)
8.	Arase, Yasuji: 59 articles (03/2014 - 01/2002)
9.	Marcellin, Patrick: 58 articles (07/2015 - 01/2002)
10.	Kobayashi, Masahiro: 56 articles (03/2014 - 01/2002)

Related Diseases

1.	Infection 12/01/2015 - "Interferon-based HCV treatment is highly effective in recent HCV infection. " 08/01/2015 - "Recent advances in the treatment of hepatitis C virus (HCV) infection have led to the availability of both highly efficacious interferon-containing and interferon-sparing regimens. " 11/01/2014 - "However, the anticipated availability of safe, tolerable and highly efficacious interferon-free, oral HCV direct-acting antiviral combination therapies promise to dramatically change the management of acute and chronic HCV infection in HIV-infected persons. " 01/01/2010 - "All the 5 interferon inducible genes are highly expressed in SLE patients, in which ISG15 and LY6E are independently associated with disease flare, while OASL may be helpful for the evaluation of infection in SLE patients." 01/01/2010 - "Treatment of acute HCV infection with interferon-based therapy has been shown to be highly efficacious, with sustained virological response rates in between 60% and 70% of HIV-positive individuals. "
2.	Chronic Hepatitis C 01/01/1994 - "We conclude that repeated interferon alpha-2b treatment courses are probably beneficial in patients with chronic hepatitis C who show a non-sustained response to interferon, since studies on the natural course of chronic hepatitis C have indicated a progressive deterioration of the histological picture in many untreated patients, most marked among those with CAH." 04/01/2003 - "The best treatment for chronic hepatitis C patients who do not respond to interferon is still unknown. " 09/01/1998 - "Short courses (6 months) of interferon (IFN) are highly cost-effective in patients with histologically mild chronic hepatitis C. " 04/01/1998 - "The best results in terms of clinical remission in chronic hepatitis C are achieved by interferon (IFN)-alpha treatment. " 01/01/1998 - "In an attempt to determine the best therapeutic protocol for the treatment of chronic hepatitis C with interferon (IFN), we reported our experience comparing the efficacy of IFN at the usual dose and duration, i.e. "
3.	Hepatitis C 10/01/2007 - "Perhaps the most significant recent advance in this area is our improved understanding of the safety and efficacy of interferon-based antiviral therapies for children with hepatitis C. " 08/01/2002 - "To our knowledge, this is the first reported hepatitis C patient showing anti-RNP antibody and anti-SSB antibody, having complete remission after interferon therapy." 12/01/1996 - "Prediction of response to interferon therapy is important in the management of chronic hepatitis C. " 11/01/2007 - "Hepatitis C patients with stable psychiatric history can be successfully treated with interferon-based therapy if followed closely by a multidisciplinary team that includes specialists in hepatitis C and behavioral health." 03/01/2001 - "Results of Phase II/III hepatitis C clinical trials in humans confirmed the superior efficacy of pegylated interferon alpha-2a compared to unmodified interferon alpha-2a."
4.	Neoplasms (Cancer) 11/01/2006 - "A plasmid encoding murine interferon (IFN)-beta or IFN-gamma with reduced numbers of CpG motifs was highly effective in inhibiting metastatic tumor growth in mice. " 08/15/1986 - "Interferon was most effective when injected at the site of tumor inoculation rather than at a distant site. " 11/01/2010 - "Type I and type II classes of interferons (IFNs) signal through the JAK/STAT1 pathway and are known to be important in adaptive and innate immune responses and in protection against tumors. " 10/01/1994 - "However, the presence of a minority of Ph-positive CML progenitor cells for a very long period of time is still compatible with durable remission, confirming that a situation of tumor dormancy may be induced in CML by interferon therapy." 11/01/1985 - "We have further demonstrated that subcutaneous administration of interferon, subsequent to the introduction of a tumorigenic dose of Ad12-transformed cells, results in complete protection against this tumor. "
5.	Chronic Hepatitis B 08/01/2012 - "However, in striking contrast to the situation in chronic hepatitis B and C, no new drugs for its treatment have been introduced in the recent past and interferons remain the only evidence-based effective treatment of CDH. " 12/14/2007 - "The treatment of chronic hepatitis B has improved dramatically over the last decade merits to the advent of nucleoside/nucleotide analogues and the use of pegylated interferons. " 01/01/2006 - "The treatment of chronic hepatitis B has improved dramatically over the last decade thanks to the advent of nucleoside/nucleotide analogues and the use of pegylated interferons. " 09/01/1994 - "Interferon is the sole drug yet proven to be effective in the treatment of some patients with chronic hepatitis B and C. " 05/01/1999 - "Chronic hepatitis B treatment has been significantly improved by interferon (IFN) treatment. "

Related Drugs and Biologics

1.	Ribavirin (Virazole)
2.	Antigens
3.	Interferon-alpha (Interferon Alfa)
4.	RNA (Ribonucleic Acid)
5.	Lamivudine (3TC)
6.	Fluorouracil (Carac)
7.	Hepatitis B e Antigens
8.	Interleukin-2 (IL2)
9.	Interleukins
10.	DNA (Deoxyribonucleic Acid)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Retreatment
3.	Aftercare (After-Treatment)
4.	Liver Transplantation
5.	Transplants (Transplant)