Glycoconjugates

Carbohydrates covalently linked to a nonsugar moiety (lipids or proteins). The major glycoconjugates are glycoproteins, glycopeptides, peptidoglycans, glycolipids, and lipopolysaccharides. (From Biochemical Nomenclature and Related Documents, 2d ed; From Principles of Biochemistry, 2d ed)

Networked: 716 relevant articles (3 outcomes, 67 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zwierz, Krzysztof: 7 articles (01/2014 - 07/2007)
2.	Waszkiewicz, Napoleon: 7 articles (01/2014 - 01/2011)
3.	Szajda, Sławomir Dariusz: 5 articles (01/2014 - 01/2011)
4.	Kępka, Alina: 5 articles (01/2014 - 01/2011)
5.	Schumacher, Udo: 4 articles (04/2015 - 09/2005)
6.	Imberty, Anne: 4 articles (01/2015 - 11/2005)
7.	Körner, Christian: 3 articles (11/2015 - 03/2012)
8.	Thiel, Christian: 3 articles (11/2015 - 03/2012)
9.	Ye, Xin-Shan: 3 articles (10/2015 - 01/2003)
10.	Vidal, Sébastien: 3 articles (08/2014 - 12/2009)

Related Diseases

1.	Infection 07/17/2015 - "The two glycoconjugates were also effective in protecting newborn mice against GBS infection following vaccination of the dams. " 11/01/2015 - "These results indicate that NanA-induced desialylation of cell surface glycoconjugates is essential for the initial step of E. tarda infection. " 10/01/2015 - "These glycoconjugates are particularly abundant in the promastigote form and known to be essential for establishment of infection in the insect midgut and effective transmission to the mammalian host. " 10/01/2015 - "Leishmania parasites synthesise a wide array of cell surface and secreted glycoconjugates that play important roles in infection. " 01/24/2014 - "D-Galactofuranose (D-Galf) is present in glycoconjugates of several pathogenic microorganisms but is absent in mammals, so it is a good target for the development of chemotherapeutic agents for the treatment of microbial infections. "
2.	Psoriasis (Pustulosis Palmaris et Plantaris) 07/01/1986 - "Restoration of the membrane staining tended to precede improvement in clinical and histologic features of psoriasis, suggesting that normalization of the altered profiles of membrane glycoconjugates is one of the beneficial effects of PUVA irradiation on psoriatic epidermis." 12/01/1984 - "On the basis of these findings and in comparison with previous findings of our group on hyperproliferative, malignant keratinocytes, it is concluded that particularly the disordered cytoplasmic transport of alpha-L-fucose-carrying glycoconjugates may represent a specific defect in psoriasis, possibly linked with the pathogenesis of this disease." 11/01/1983 - "We have used Ulex europaeus I (UEA I) lectin, specific for alpha-L-fucose-containing glycoconjugates, in fluorescence microscopy to stain cryostat sections of human skin from normal persons and patients with psoriasis and lichen simplex. "
3.	Lyme Disease (Disease, Lyme) 01/01/2012 - "A significant increase in GAL activity in the serum of patients with Lyme disease indicates an increased catabolism of glycoconjugates (glycoproteins, glycolipids, proteoglycans) and could be helpful in the diagnosis of Lyme disease, although this requires confirmation in a larger group of patients. "
4.	Neoplasms (Cancer) 10/14/2005 - "The capacity of EML to bind epithelial tumor cells makes it a potentially useful tool for study of some over-expressed GalNAc glycoconjugates." 07/01/1990 - "Preliminary studies of serum glycoconjugates in patients with cancer using the enzyme-linked lectin assay." 05/01/1989 - "The purpose of this study is to investigate changes of glycoconjugates in the cancer cells of the urinary bladder by means of immunohistochemical methods. " 04/01/2015 - "Cancer cells express various aberrant glycoconjugates. " 07/01/2014 - "The relationship between the expression of the three glycoconjugates indicates a possible participation in the processes of angiogenesis and tissue remodeling during tumor development."
5.	Neoplasm Metastasis (Metastasis) 05/01/2002 - "Alteration of cell surface glycoconjugates plays a crucial role in many biological phenomenon, including invasion and metastasis. " 07/01/2001 - "Glycoconjugates, as detected by lectin histochemistry, have been implicated in metastasis formation in many neoplasias. " 01/01/1996 - "Sulphated glycoconjugates in the basal laminae have been reported to play a role in tumour invasion and metastasis. " 09/15/1990 - "Recognition of the carbohydrate part of cellular glycoconjugates by cell-surface sugar receptors may contribute to interactions, essential to the establishment of metastases. " 02/01/1988 - "These new spontaneously derived WGA resistant MeWo mutants should be valuable new tools for the study of human tumor progression in vivo and factors involved in metastasis, especially the contribution of oligosaccharide moieties of cell surface glycoconjugates."

Related Drugs and Biologics

1.	Glycoproteins (Glycoprotein)
2.	Glycolipids
3.	Proteoglycans (Proteoglycan)
4.	Lectins
5.	Galactose (Galactopyranose)
6.	N-Acetylneuraminic Acid (Sialic Acid)
7.	Acetylgalactosamine
8.	Vaccines
9.	Antigens
10.	Carbohydrates

Related Therapies and Procedures

1.	Immunotherapy
2.	Heterologous Transplantation (Xenotransplantation)
3.	Drug Therapy (Chemotherapy)
4.	Immunomodulation
5.	Therapeutics