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Mitogen-Activated Protein Kinase 10

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A c-jun amino-terminal kinase that is found predominantly within NEURONS of the BRAIN, suggesting a role in stress-induced neuronal APOPTOSIS. Several isoforms of the protein with molecular sizes of 47 kDa and 52 kDa exist due to multiple ALTERNATIVE SPLICING.

Also Known As:

JNK3 Mitogen Activated Protein Kinase; MAP Kinase p49(3F12); MAPK10 Mitogen-Activated Protein Kinase; Mitogen Activated Protein Kinase p49(3F12); Stress-Activated Protein Kinase JNK3; c-jun Kinase 3; c-jun N-Terminal Kinase 3; p49 3F12 Kinase; p49(3F12) SAP Kinase; p54-SAPK(beta); 3F12 Kinase, p49; Kinase 3, c-jun; MAPK10 Mitogen Activated Protein Kinase; Mitogen Activated Protein Kinase 10; Stress Activated Protein Kinase JNK3; c jun Kinase 3; c jun N Terminal Kinase 3

Networked: 17 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Laufer, Stefan A: 3 articles (03/2015 - 04/2011)
2.	Fischer, Sabine: 2 articles (03/2015 - 01/2015)
3.	Döring, Eva: 2 articles (03/2015 - 01/2015)
4.	Günther, Marcel: 2 articles (03/2015 - 01/2015)
5.	Muth, Felix: 2 articles (03/2015 - 01/2015)
6.	Bauer, Silke M: 2 articles (03/2015 - 01/2015)
7.	Trappe, Jörg: 2 articles (03/2015 - 01/2015)
8.	Koch, Pierre: 2 articles (03/2015 - 01/2015)
9.	Drückes, Peter: 2 articles (03/2015 - 01/2015)
10.	Rothbauer, Ulrich: 2 articles (03/2015 - 01/2015)

Related Diseases

1.	Carcinoma (Carcinomatosis) 01/01/2013 - "Furthermore, strong repression of the c-Jun N-terminal kinase 3 (JNK3) mRNA expression was found in carcinoma cells which correlated with enhanced toxicity of PTX suggesting an essential role of the mitogen activated protein kinase (MAPK)/JNK signalling cascades pathway in the mechanisms of HNSCC cell resistance to PTX. " 06/01/2014 - "In this study, the expression of miR-29b messenger RNA (mRNA) and its targeted genes, myeloid cell leukemia sequence 1, mitogen-activated protein kinase 10 (MAPK10), and autophagy-related protein 9A (ATG9A), were investigated in ovarian carcinomas, and their associations with clinicopathological characteristics and survival of patients with ovarian cancer were analyzed. "
2.	Brain Injuries (Brain Injury) 05/01/2007 - "c-Jun N-terminal kinase 3 is a potent mediator of apoptosis and the use of JNK inhibitors or jnk3 gene deletion each protect against brain injury in adults. " 06/02/2010 - "In this study we report that ethanol shows neuroprotective effects against ischemic brain injury through enhancing GABA release and then decreasing c-Jun N-terminal kinase 3 (JNK3) activation. " 06/02/2010 - "Neuroprotection of ethanol against ischemia/reperfusion-induced brain injury through decreasing c-Jun N-terminal kinase 3 (JNK3) activation by enhancing GABA release."
3.	Ovarian Neoplasms (Ovarian Cancer) 06/01/2014 - "In this study, the expression of miR-29b messenger RNA (mRNA) and its targeted genes, myeloid cell leukemia sequence 1, mitogen-activated protein kinase 10 (MAPK10), and autophagy-related protein 9A (ATG9A), were investigated in ovarian carcinomas, and their associations with clinicopathological characteristics and survival of patients with ovarian cancer were analyzed. "
4.	Heart Injuries 07/01/2003 - "To study the function of c-Jun N-terminal kinase 3 (JNK3) in the process of ischemic/reperfused heart injury and the mechanism underlying the protective action of magnesium lithospermate B (MTB), a bioactive compound isolated from Danshen. "
5.	Brain Ischemia (Cerebral Ischemia) 05/25/2012 - "This research investigated whether GluK1 could inhibit activation of c-Jun N-terminal kinase 3 (JNK3) signaling pathway mediated by the GluK2 in cerebral ischemia-reperfusion. " 06/15/2012 - "Heat shock protein 72 inhibits c-Jun N-terminal kinase 3 signaling pathway via Akt1 during cerebral ischemia." 04/01/2015 - "Momordica charantia polysaccharides could protect against cerebral ischemia/reperfusion injury through inhibiting oxidative stress mediated c-Jun N-terminal kinase 3 signaling pathway."

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	gamma-Aminobutyric Acid (GABA)
3.	Ethanol (Ethyl Alcohol)
4.	myeloid cell leukemia sequence 1 protein
5.	lithospermate B
6.	butyl 3-(1H-tetrazol-5-yl)oxanilate (MTB)
7.	Protein Kinases (Protein Kinase)
8.	Fas Ligand Protein (Fas Ligand)
9.	Caspase 3 (Caspase-3)
10.	HSP72 Heat-Shock Proteins