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gamma-Aminobutyric Acid (GABA)

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The most common inhibitory neurotransmitter in the central nervous system.

Also Known As:

GABA; 4-Aminobutanoic Acid; Aminalon; Aminalone; Gammalon; Lithium GABA; gamma-Aminobutyric Acid, Calcium Salt (2:1); gamma-Aminobutyric Acid, Hydrochloride; gamma-Aminobutyric Acid, Monolithium Salt; gamma-Aminobutyric Acid, Monosodium Salt; gamma-Aminobutyric Acid, Zinc Salt (2:1); 4 Aminobutanoic Acid; 4 Aminobutyric Acid; Acid, Hydrochloride gamma-Aminobutyric; GABA, Lithium; Hydrochloride gamma-Aminobutyric Acid; gamma Aminobutyric Acid; gamma Aminobutyric Acid, Hydrochloride; gamma Aminobutyric Acid, Monolithium Salt; gamma Aminobutyric Acid, Monosodium Salt; 4-Aminobutyric Acid; Butanoic acid, 4-amino-

Networked: 6435 relevant articles (212 outcomes, 791 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lewis, David A: 56 articles (11/2015 - 10/2002)
2.	Ben-Ari, Yehezkel: 21 articles (08/2015 - 11/2003)
3.	Volk, David W: 18 articles (09/2015 - 10/2002)
4.	Hashimoto, Takanori: 18 articles (01/2014 - 07/2003)
5.	Benes, Francine M: 17 articles (09/2015 - 06/2002)
6.	Petrou, Steven: 16 articles (05/2015 - 11/2002)
7.	Gibson, K Michael: 15 articles (01/2013 - 01/2003)
8.	Jensen, J Eric: 14 articles (01/2015 - 11/2005)
9.	Renshaw, Perry F: 14 articles (06/2013 - 04/2004)
10.	Edden, Richard A E: 13 articles (11/2015 - 02/2012)

Related Diseases

1.	Seizures (Seizure) 02/01/2008 - "Enhanced GABA activity resulted in a significant reduction of seizure duration. " 09/01/1990 - "There was significantly greater sensitivity to GABA in stimulated El mice (which had 14-18 convulsions induced at weekly intervals) than in unstimulated El mice (which had not experienced convulsions) or ddY mice. " 09/01/2011 - "This might, in part, explain not only the higher seizure propensity of the immature neuronal network, but also the limited anticonvulsive efficacy of GABA-enhancing drugs during early postnatal life. " 02/01/1986 - "These results are consistent with the concept that drugs which facilitate GABAergic transmission are effective against seizures related to an impairment of GABA transmission. " 06/04/1987 - "These results further support the hypothesis that elevation of cerebral GABA levels is protective against a range of experimentally induced seizures, particularly when the substantia nigra is the target of such manipulations."
2.	Epilepsy (Aura) 02/01/1993 - "Previous studies have shown significantly greater GABA levels and numbers of GABAergic neurons in the central nucleus of the inferior colliculus (ICCN) of genetically epilepsy-prone rats (GEPR-9s). " 05/01/2004 - "It is suggested that subacute electrical stimulation of PHC is more effective in patients with less severe epilepsy, an effect associated with a high GABA tissue content and a low rate of cell loss." 07/01/1986 - "The iontophoretic dose (current) of GABA required to suppress neuronal firing in the epilepsy-prone rat was significantly greater than that required in neurons of the normal rat. " 10/01/1996 - "Drugs which increase the amount of GABA available in presynaptic endings might thus be useful in the treatment of these therapeutically complicated forms of epilepsy. " 06/01/2009 - "Although some of these second generation compounds may be advantageous in terms of kinetics, tolerability and potential for drug interactions, all of them still target voltage-gated channels or GABA-mediated inhibition, predominantly, without any real improvement in epilepsy therapy. "
3.	Pain (Aches) 10/09/2009 - "Equally importantly, the GABA concentration in the spinal cord increased significantly after GAD65 introduction, and pain symptoms were dramatically reduced and persistently controlled. " 06/01/2013 - "Finally, the modulation of GABA and gamma oscillations with repetitive TMS will be suggested as the possible mechanism through which rTMS exerts its therapeutic effects in the treatment of pain. " 03/01/2009 - "The results are in line with animal findings on the role of GABA in pain processing and with studies in humans showing analgesic efficacy of GABA-related drugs in clinical pain conditions." 03/09/2013 - "The pain plus GABA-hATSCs-engrafted animal groups showed paw withdrawal thresholds (PWTs) that gradually improved. " 01/01/2013 - "Positive results would support further investigation of GABA agonism for the control of clinical pain. "
4.	Schizophrenia (Dementia Praecox) 09/01/2008 - "The findings of altered neural synchrony and impaired cognitive function in schizophrenia suggest that such compensatory responses are insufficient and that interventions aimed at augmenting the efficacy of GABA neurotransmission might be of therapeutic value." 11/01/2015 - "This study demonstrates, for the first time, an in vivo impairment in GABA transmission in schizophrenia, most prominent in antipsychotic-naive individuals. " 11/01/2015 - "However, results of in vivo studies of schizophrenia measuring total tissue GABA with magnetic resonance spectroscopy (MRS) have been inconsistent. " 11/01/2015 - "Postmortem studies in schizophrenia reveal alterations in gene products that regulate the release and extracellular persistence of GABA. " 09/01/2015 - "GABA abnormalities in schizophrenia: a methodological review of in vivo studies."
5.	Neuralgia (Stump Neuralgia) 10/01/2005 - "Although the role of T and GABA(A) currents in pathophysiology of neuropathic pain (NPP) is not established, it appears that blockade of T currents and/or potentiation of GABA(A) currents could be beneficial in the management of NPP. " 01/01/2015 - "However, GABA alteration has been explored in only one study on trigeminal neuropathic pain. " 04/25/2005 - "The present study was undertaken to explore the role of gamma-aminobutyric acid transporters in the neuropathic pain. " 07/01/2003 - "Several studies have described a substantial loss of GABA-immunoreactive neurons from the dorsal horn in nerve injury models, and it has been suggested that this may be associated with a loss of inhibition, which contributes to the behavioural signs of neuropathic pain. " 04/15/2015 - "Engagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic pain."

Related Drugs and Biologics

1.	gamma-Aminobutyric Acid (GABA)
2.	Anticonvulsants (Antiepileptic Drugs)
3.	gabapentin (Neurontin)
4.	Neurotransmitter Agents (Neurotransmitter)
5.	Vigabatrin
6.	Glutamic Acid (Glutamate)
7.	Baclofen
8.	Pentylenetetrazole (Metrazol)
9.	GABA-A Receptors (GABA(A) Receptor)
10.	tiagabine (Gabitril)

Related Therapies and Procedures

1.	Injections
2.	Intravenous Injections
3.	Oral Administration
4.	Transplants (Transplant)
5.	Transplantation (Transplant Recipients)