Abstract | OBJECTIVE: METHODS: RESULTS: We found that PLZF expression was significantly down-regulated in HCC samples compared with that in adjacent non- tumor tissues (P=0.001). The expression level of PLZF was correlated with patients' gender (P=0.046), tumor stage (P=0.039), and OS (P=0.015). Moreover, the expression level of PLZF-MAPK10 (P-M protein) was correlated with gender (P=0.000) and tumor stage (P=0.045). Multivariate analyses showed that microsatellite nodules, PLZF, and P-M protein were independent risk factors of HCC prognosis. Postoperative patients with a normal expression level of PLZF and MAPK10 have a longer overall survival than those with abnormal levels (P=0.039). CONCLUSION: PLZF expression was significantly down-regulated in HCC tissues and itself and PLZF-MAPK10 were both independent prognostic factors for the OS of patients with HCC.
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Authors | Shanshan Hu, Yue Chen, Liheng Liu, Xuedong Yin, Yaying Yang, Liping Tang |
Journal | International journal of clinical and experimental pathology
(Int J Clin Exp Pathol)
Vol. 13
Issue 12
Pg. 3158-3166
( 2020)
ISSN: 1936-2625 [Electronic] United States |
PMID | 33425116
(Publication Type: Journal Article)
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Copyright | IJCEP Copyright © 2020. |