Angiopoietin-2

An angiopoietin that is closely related to ANGIOPOIETIN-1. It binds to the TIE-2 RECEPTOR without receptor stimulation and antagonizes the effect of ANGIOPOIETIN-1. However its antagonistic effect may be limited to cell receptors that occur within the vasculature. Angiopoietin-2 may therefore play a role in down-regulation of BLOOD VESSEL branching and sprouting.

Also Known As:

Networked: 645 relevant articles (7 outcomes, 70 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	David, Sascha: 16 articles (07/2015 - 01/2008)
2.	Kümpers, Philipp: 16 articles (03/2013 - 01/2008)
3.	Haller, Hermann: 14 articles (07/2015 - 01/2008)
4.	Kielstein, Jan T: 11 articles (07/2015 - 01/2008)
5.	Lukasz, Alexander: 11 articles (01/2014 - 01/2008)
6.	Liles, W Conrad: 10 articles (01/2015 - 01/2011)
7.	De Palma, Michele: 8 articles (02/2015 - 06/2007)
8.	Bhandari, Vineet: 8 articles (01/2014 - 05/2007)
9.	Reiss, Yvonne: 7 articles (07/2015 - 02/2006)
10.	Giamarellos-Bourboulis, Evangelos J: 7 articles (01/2014 - 11/2008)

Related Diseases

1.	Neoplasms (Cancer) 03/15/2013 - "Angiopoietin-2: an attractive target for improved antiangiogenic tumor therapy." 08/01/2015 - "Angiopoietin-2 (Ang-2) blocking agents are currently undergoing clinical trials for use in cancer treatment. " 01/01/2015 - "Angiogenesis plays a decisive role in the growth and spread of cancer and angiopoietin-2 (Ang2) is in the spotlight of studies for its unique role in modulating angiogenesis. " 08/15/2015 - "Lower baseline levels of angiopoietin-2 were suggestive of tumor response and longer PFS. " 05/01/2015 - "Angiopoietin 2 (ANGPT2) is a crucial factor regulating tumor angiopoiesis. "
2.	Inflammation 06/01/2012 - "Fluid conservative therapy preferentially lowers plasma angiopoietin-2 levels over time and thus may be beneficial in part by decreasing endothelial inflammation." 07/01/2015 - "Angiopoietin-2: a multifaceted cytokine that functions in both angiogenesis and inflammation." 12/01/2013 - "Angiopoietin-2 generally has an opposing action, and is released naturally at times of vascular growth and inflammation. " 09/01/2013 - "Angiopoietin-2 (Angpt-2), a marker of endothelial cell activation, has been proposed as a mediator of angiogenesis, which might play an important role in the regulation of endothelial integrity and inflammation. " 07/01/2012 - "Angiopoietin-2 (ang-2) that activates endothelial cells and increases vascular inflammation might have significant roles in the pathogenesis of glomerular diseases. "
3.	Sepsis (Septicemia) 10/01/2014 - "Manifestations of sepsis were also attenuated in distant organs, including the kidney, where renal function was improved without affecting local angiopoietin-2 production. " 10/01/2014 - "Lung-targeted RNA interference against angiopoietin-2 ameliorates multiple organ dysfunction and death in sepsis." 07/01/2015 - "Drug Repurposing Screen Identifies Foxo1-Dependent Angiopoietin-2 Regulation in Sepsis." 05/01/2015 - "Angiopoietin-2 (Ang-2) is an important mediator in sepsis. " 10/01/2014 - "The Tie2 antagonist angiopoietin-2 represents a promising target against sepsis-associated multiple organ dysfunction. "
4.	Macular Degeneration (Age-Related Maculopathy) 09/04/2015 - "Here, we engineered a Two-in-One VEGF/angiopoietin 2 antibody with dual action Fab (DAF) as a potential therapeutic for neovascular age-related macular degeneration. " 01/01/2012 - "The aim of this study was to investigate the levels of pigment epithelium-derived factor (PEDF), angiopoietin 2, vascular endothelial growth factor (VEGF), and soluble VEGF receptor 1 (sVEGFR-1) in vitreous samples of patients suffering from age-related macular degeneration with choroidal neovascularization or from proliferative diabetic retinopathy (PDR). "
5.	Systemic Scleroderma (Systemic Sclerosis) 04/01/2011 - "Angiopoietins-1 and -2 are differentially expressed in the sera of patients with systemic sclerosis: high angiopoietin-2 levels are associated with greater severity and higher activity of the disease." 09/01/2013 - "Dynamics of serum angiopoietin-2 levels correlate with efficacy of intravenous pulse cyclophosphamide therapy for interstitial lung disease associated with systemic sclerosis."

Related Drugs and Biologics

1.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
2.	glucuronyl glucosamine glycan sulfate (Vessel)
3.	Cyclophosphamide (Cytoxan)
4.	Angiopoietin-1
5.	Messenger RNA (mRNA)
6.	TIE-2 Receptor (Receptor, TIE 2)
7.	Biological Markers (Surrogate Marker)
8.	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
9.	angiogenin
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Transplants (Transplant)
3.	Drug Therapy (Chemotherapy)
4.	Vitrectomy
5.	Homologous Transplantation (Allograft)