Transforming Growth Factors (Transforming Growth Factor)

Hormonally active polypeptides that can induce the transformed phenotype when added to normal, non-transformed cells. They have been found in culture fluids from retrovirally transformed cells and in tumor-derived cells as well as in non-neoplastic sources. Their transforming activities are due to the simultaneous action of two otherwise unrelated factors, TRANSFORMING GROWTH FACTOR ALPHA and TRANSFORMING GROWTH FACTOR BETA.

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Networked: 4743 relevant articles (69 outcomes, 452 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Miyazono, Kohei: 17 articles (08/2014 - 03/2003)
2.	Zhang, Wei: 15 articles (01/2016 - 02/2007)
3.	Varga, John: 14 articles (05/2015 - 01/2008)
4.	ten Dijke, Peter: 12 articles (06/2015 - 04/2007)
5.	Li, Jun: 11 articles (09/2015 - 02/2010)
6.	Weller, Michael: 10 articles (09/2015 - 10/2004)
7.	Schiemann, William P: 10 articles (03/2015 - 01/2006)
8.	Guise, Theresa A: 9 articles (11/2015 - 07/2002)
9.	Dietz, Harry C: 9 articles (05/2015 - 04/2011)
10.	Distler, Jörg H W: 9 articles (03/2015 - 05/2012)

Related Diseases

1.	Fibrosis (Cirrhosis) 11/01/2015 - "Certain studies have shown that epithelial-mesenchymal transition (EMT) regulated by transforming growth factor-β (TGF-β) is involved in fibrosis. " 05/01/2014 - "Further studies revealed that targeting the transforming growth factor (TGF)-β1 coding sequence region, thereby inhibiting TGF-β/Smad3 signaling, could be a new mechanism by which miR-29b inhibited AngII-induced cardiac fibrosis. " 01/01/2014 - "Recent studies have found that transforming growth factor-β (TGF-β) plays a central role in fibrosis. " 04/01/2012 - "In this study, we analyzed the function of miR-200a and miR-200b in intestinal fibrosis, which was induced by transforming growth factor β1 (TGF-β1) in vitro. " 09/01/2011 - "Our previous study indicated that bone morphogenetic protein-2 (BMP-2) significantly reversed transforming growth factor (TGF)-β1-induced renal interstitial fibrosis. "
2.	Neoplasms (Cancer) 04/01/2009 - "Further, we show that by precisely timing neutralization of transforming growth factor-β (TGF-β) within treated tumors using a TGF-β-soluble receptor, the efficacy of the treatment can be significantly improved, resulting in tumor regression. " 12/01/2010 - "Pharmacological inhibitors of the transforming growth factor β (TGFβ) type I receptor (ALK5) have shown promise in blocking growth of xenotransplanted cancer cell lines but the effect on a multistage cancer model is not known. " 12/01/2015 - "In the present study, we investigated the association of transforming growth factor (TGF)-β1 levels and various markers of tumor aggressiveness and explore some potential mechanisms underlying the associations. " 12/01/2015 - "The present study investigates the potential roles of AMPK in inhibiting cancer-cell migration and epithelial-to-mesenchymal transition (EMT) by regulating the canonical transforming growth factor β (TGF-β) signaling pathway, an important promoting factor for cancer progression. " 07/01/2015 - "This study aims to investigate the role of cancer-derived microvesicles (Mvcs) in the generation of transforming growth factor (TGF)-β(+) B cells. "
3.	Liver Cirrhosis (Hepatic Cirrhosis) 04/01/2012 - "Recent studies have demonstrated that transforming growth factor-β1 (TGF-β1) and connective transforming growth factor (CTGF) are associated with the pathophysiology of liver fibrosis. " 09/01/2015 - "Transforming growth factor (TGF-β) induced activation of portal fibroblast cells serves as a primary cause for liver fibrosis following cholestatic injury. " 06/01/2015 - "Transforming growth factor β1 (TGF-β1) plays a crucial role in the pathogenesis of liver fibrosis. " 04/01/2015 - "The transforming growth factor (TGF)-β1 plays a crucial role in the induction of the epithelial-to-mesenchymal transition (EMT) in hepatocytes, which contributes to the pathogenesis of liver fibrosis. " 02/01/2015 - "Genes related to liver fibrosis were detected after NS5ATP9 overexpression or silencing with or without transforming growth factor (TGF)-β1 stimulation in the human HSCs by real-time polymerase chain reaction and western blotting. "
4.	Wounds and Injuries (Trauma) 03/01/2010 - "Remarkably, impaired wounds showed elevated levels of transforming growth factor (TGF)-beta1, which appeared to interfere with healing, as its neutralization markedly improved wound closure in transgenic mice. " 10/29/2005 - "Transforming growth factors (TGF-alpha and TGF-beta1) in the determination of vitality and wound age: immunohistochemical study on human skin wounds." 12/15/2012 - "Periostin was upregulated by transforming growth factor-β in lung mesenchymal cells, and periostin promoted extracellular matrix deposition, mesenchymal cell proliferation, and wound closure. " 12/01/2012 - "Transforming growth factor-β (TGF-β) superfamily controls many physiological processes such as cell proliferation and differentiation, immune responses, wound repair and various endocrine activities. " 10/01/2011 - "Transforming growth factor (TGF)-β promotes VIC proliferation in early-stage wound repair; thus, herein, we tested the hypothesis that TGF-β regulates VIC proliferation under normal nonwound conditions using low-density porcine VIC monolayers. "
5.	Inflammation 06/01/2015 - "Our prior study found  that transforming growth factor  beta-induced (TGFBI) is  an important negative regulator in TLR-induced inflammation. " 01/01/2014 - "Most studies have focused on IL-10-producing B cells, but we have previously reported that transforming growth factor (TGF)-β1 secretion by B cells also plays an important role in intestinal homeostasis and mucosal inflammation. " 10/01/2015 - "We used a transgenic mice model (transforming growth factor [TGF] mice) to develop a high T cell-dependent inflammation and C57 BL/6 control (CTL) mice model. " 07/26/2015 - "Transforming growth factor-β has extraordinarily important roles in all phases of inflammation and in the specific immune response. " 07/01/2015 - "Transforming growth factor beta-1 (TGF-β1) is an important regulator of inflammation. "

Related Drugs and Biologics

1.	Collagen
2.	Transforming Growth Factor beta (TGF-beta)
3.	Messenger RNA (mRNA)
4.	Cytokines
5.	Fibronectins (Fibronectin)
6.	Hydroxyproline (4 Hydroxyproline)
7.	Interleukin-10 (Interleukin 10)
8.	Phosphotransferases (Kinase)
9.	Interleukin-6 (Interleukin 6)
10.	Interferons

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Transplantation (Transplant Recipients)
3.	Intraperitoneal Injections
4.	Transcutaneous Electric Nerve Stimulation (TENS)
5.	Amputation