Limb Salvage

An alternative to AMPUTATION, SURGICAL in patients with neoplasms, ischemia, fractures, and other limb-threatening conditions. Generally, sophisticated surgical procedures such as vascular surgery and reconstruction are used to salvage diseased limbs.
Also Known As:
Salvage, Limb
Networked: 3365 relevant articles (226 outcomes, 291 trials/studies)

Relationship Network

Therapy Context: Research Results


1. Attinger, Christopher E: 25 articles (09/2022 - 04/2002)
2. Evans, Karen K: 18 articles (09/2022 - 01/2015)
3. Dosluoglu, Hasan H: 16 articles (10/2022 - 11/2006)
4. Harris, Linda M: 16 articles (10/2022 - 11/2006)
5. Guo, Wei: 16 articles (12/2020 - 10/2006)
6. Dryjski, Maciej L: 15 articles (10/2022 - 11/2006)
7. Li, Jing: 15 articles (02/2022 - 06/2010)
8. Mavrogenis, Andreas F: 15 articles (12/2021 - 12/2003)
9. Wang, Zhen: 14 articles (02/2022 - 06/2010)
10. Guo, Zheng: 13 articles (01/2022 - 06/2010)

Related Diseases

1. Neoplasms (Cancer)
2. Ischemia
12/01/2003 - "The best TcpO(2) parameters to predict the efficacy of spinal cord stimulation to improve limb salvage in patients with inoperable critical leg ischemia."
01/01/1996 - "The limb salvage rate for patients with limb-threatening ischemia was 98% at a mean follow-up of 14 months +/- 7. Technical success and complication rates for percutaneous iliac artery revascularization with use of Wallstents are favorable, symptoms improved in the majority of patients, and excellent secondary patency can be achieved. "
10/16/2020 - "Injecting the CM collected from ps-TNC treated hADSCs into the mouse hindlimb ischemia model (ps-TNC-CM group) showed significantly improved angiogenesis in the lesions, with improved limb salvage and decreased muscle degeneration compared to the group injected with CM collected from normal hADSCs (CM group). "
04/01/2014 - "Compared with injection of either monolayer culture CM or human ADSC, injection of spheroid culture CM to an ischemic region in mice significantly enhanced endothelial cell growth, CD34(+)/PTPRC(-) (endothelial progenitor) cell mobilization from bone marrow, and bone marrow cell homing to the ischemic region, resulting in improved blood vessel density, limb salvage, and blood perfusion in a mouse hindlimb ischemia model. "
09/01/2005 - "At 12 months, the secondary patency and limb salvage rates were, respectively, 87.5+/-8.9 and 100% in group I and 87.5+/-8.93 and 94.45+/-6.71% in group II. Treatment of SFA occlusive lesions (excluding TASC D lesions) with the Hemobahn covered stent yielded good results for both claudicants with good outflow and patients with critical or acute ischemia with bad outflow, if concomitant outflow-improving procedures were performed."
3. Wounds and Injuries (Trauma)
4. Osteosarcoma (Osteogenic Sarcoma)
5. Pain (Aches)

Related Drugs and Biologics

1. Polytetrafluoroethylene (Teflon)
2. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
3. Melatonin
4. Anti-Bacterial Agents (Antibiotics)
5. Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)
6. Heparin (Liquaemin)
7. Oxygen (Dioxygen)
8. Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
9. Superoxide Dismutase
10. Ointments (Pastes)

Related Therapies and Procedures

1. Surgical Amputation (Amputations)
2. Drug Therapy (Chemotherapy)
3. Neoadjuvant Therapy
4. Therapeutics
5. Radiotherapy