Angiopoietin-1

The first to be discovered member of the angiopoietin family. It may play a role in increasing the sprouting and branching of BLOOD VESSELS. Angiopoietin-1 specifically binds to and stimulates the TIE-2 RECEPTOR. Several isoforms of angiopoietin-1 occur due to ALTERNATIVE SPLICING of its mRNA.

Also Known As:

Networked: 820 relevant articles (28 outcomes, 104 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Liles, W Conrad: 15 articles (11/2021 - 09/2007)
2.	Koh, Gou Young: 13 articles (04/2014 - 04/2006)
3.	Han, Shu: 11 articles (10/2021 - 04/2010)
4.	Chopp, Michael: 10 articles (01/2022 - 02/2002)
5.	Kain, Kevin C: 8 articles (04/2022 - 01/2009)
6.	Jiang, Hong: 8 articles (10/2021 - 11/2014)
7.	Stewart, Duncan J: 8 articles (01/2017 - 05/2003)
8.	Blann, Andrew D: 8 articles (08/2013 - 01/2004)
9.	Kümpers, Philipp: 8 articles (01/2013 - 01/2008)
10.	Zacharek, Alex: 7 articles (01/2022 - 01/2009)

Related Diseases

1.	Neoplasms (Cancer) 09/15/2016 - "A Phase I, First-in-Human Study of AMG 780, an Angiopoietin-1 and -2 Inhibitor, in Patients with Advanced Solid Tumors." 05/09/2023 - "Angiopoietin-1 (ANG1) is a pro-angiogenic regulator that contributes to the progression of solid tumors by stimulating the proliferation, migration and tube formation of vascular endothelial cells, as well as the renewal and stability of blood vessels. " 06/01/2021 - "Expression of distinct vascular leakage-related genes (Angiopoietin-1 (ANG-1), ANG-2, TIE2, VEGFR1, VEGFR2) was significantly altered in tumor tissue of OC patients (p = 0.003), while in tumor-free peritoneal tissue, ANG-2/1 expression ratio was more than doubled in OC group (p = 0.03). " 08/16/2020 - "The plasma angiopoietin-1 was downregulated from the median 971.3 pg/mL (interquartile range [IQR] 532.1-1569.3) to 417.9 (IQR 270.5-597.3) after tumor resection (p = 0.0020). " 03/01/2017 - "Here, we extend these findings to examine the expression of the pericyte markers angiopoietin-1 and -2 (Ang-1 and -2) among perivascular soft tissue tumors. "
2.	Inflammation (Inflammations) 04/28/2006 - "Angiopoietin-1 (Ang1) has powerful vascular protective effects: suppressing plasma leakage, inhibiting vascular inflammation, and preventing endothelial death. " 11/07/2017 - "In this study, we investigated the protective effect of COMP-angiopoietin-1 (COMP-Ang1), a potent variant of angiopoietin-1, on vascular endothelial cells in epididymal adipose tissue and its regulatory effect on other metabolic parameters, such as lipid droplet diameter, macrophage infiltration, and renal inflammation in STZ-treated mice. " 08/23/2023 - "Angiopoietin-1 (Angpt-1) promotes vessel stability by decreasing inflammation, apoptosis and vessel permeability. " 03/01/2018 - "Angiopoietin-1 (Ang1) is reported to have the ability to attenuate endothelial permeability and inflammation during the stress condition and is considered to play a critical role in vascular stabilization. " 01/01/2016 - "Angiopoietin-1 was more effective than C16 for reducing inflammation-induced vascular leakage. "
3.	Hypoxia (Hypoxemia) 01/01/2008 - "Furthermore, pSV-HIF1alpha induced the endogenous hypoxia-responsive genes such as angiopoietin-1, which would be beneficial for therapeutic angiogenesis. " 05/01/2011 - "In the study, we constructed hypoxic response elements (HRE) and the Tet-On advanced double-controlled systems and investigated their effects on the expression of hVEGF165 and angiopoietin-1 (Ang-1) genes in rat cardiomyocytes exposed to hypoxia and pharmacologic induction. " 01/08/2016 - "Expression of angiopoietin-1 in hypoxic pericytes: Regulation by hypoxia-inducible factor-2α and participation in endothelial cell migration and tube formation." 07/15/2012 - "Recombinant canstatin reduces the expression of angiopoietin-1 in hypoxia-induced CT-26 cells and inhibits the angiogenic and lymphangiogenic signaling induced by angiopoietin-1. " 12/15/2009 - "Overexpression of AEG-1 increases expression of molecular markers of angiogenesis, including angiopoietin-1, matrix metalloprotease-2, and hypoxia-inducible factor 1-alpha. "
4.	Sepsis (Septicemia) 12/01/2022 - "The study investigated the plasma levels of angiopoietin-1/-2 and their association with clinical outcomes of sepsis in plasma from 105 patients with severe sepsis by ELISA. " 12/01/2022 - "The current study investigated the plasma levels of angiopoietin-1/-2 and their association with clinical outcomes of sepsis. " 02/03/2023 - "Detrimental effects of PCSK9 loss-of-function in the pediatric host response to sepsis are mediated through independent influence on Angiopoietin-1." 01/01/2023 - "Angiopoietin-1 supplementation or Hgf knockdown reduced hepatocyte C/EBPβ accumulation, restored liver function, and reduced mortality, suggesting that endothelial dysfunction induced by sepsis drives ACLF through HGF-C/EBPβ pathway. " 01/01/2023 - "Detrimental effects of PCSK9 loss-of-function in the pediatric host response to sepsis are mediated through independent influence on Angiopoietin-1."
5.	Acute Lung Injury 09/01/2007 - "Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1." 05/15/2007 - "Cell-based angiopoietin-1 gene therapy for acute lung injury." 04/01/2013 - "Adenovirus-delivered angiopoietin-1 treatment for phosgene-induced acute lung injury." 09/01/2010 - "Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patients." 06/30/2008 - "Angiopoietin-1 variant, COMP-Ang1 attenuates hydrogen peroxide-induced acute lung injury."

Related Drugs and Biologics

1.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
2.	Proteins (Proteins, Gene)
3.	trebananib
4.	Peptides (Polypeptides)
5.	Angiopoietin-2
6.	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)
7.	TIE-2 Receptor (Receptor, TIE 2)
8.	Angiopoietins
9.	Occludin
10.	C16 peptide

Related Therapies and Procedures

1.	Therapeutics
2.	Vitrectomy
3.	Microspheres (Microsphere)
4.	Drug Therapy (Chemotherapy)
5.	Microbubbles