Bioreactors

Tools or devices for generating products using the synthetic or chemical conversion capacity of a biological system. They can be classical fermentors, cell culture perfusion systems, or enzyme bioreactors. For production of proteins or enzymes, recombinant microorganisms such as bacteria, mammalian cells, or insect or plant cells are usually chosen.

Also Known As:

Networked: 458 relevant articles (17 outcomes, 60 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Behie, Leo A: 9 articles (01/2013 - 03/2002)
2.	Sen, Arindom: 8 articles (01/2013 - 03/2002)
3.	Matsuura, Tomokazu: 6 articles (05/2009 - 09/2003)
4.	Kurhanewicz, John: 5 articles (10/2015 - 02/2010)
5.	Van Criekinge, Mark: 5 articles (10/2015 - 02/2010)
6.	Wilson, David M: 5 articles (10/2015 - 02/2010)
7.	Keshari, Kayvan R: 5 articles (10/2015 - 02/2010)
8.	Mendez, Ivar: 5 articles (01/2013 - 11/2007)
9.	Kallos, Michael S: 5 articles (08/2010 - 03/2002)
10.	Sriram, Renuka: 4 articles (10/2015 - 01/2013)

Related Diseases

1.	Liver Failure 06/14/2014 - "The efficacy of this novel bioreactor is promising for the study of liver failure." 12/01/1998 - "In the present study, we investigated the efficacy of the NWF bioreactor in a direct hemoperfusion experiment conducted to treat pigs with liver failure. " 04/01/2001 - "Efficacy of nonwoven fabric bioreactor immobilized with porcine hepatocytes for ex vivo xenogeneic perfusion treatment of liver failure in dogs." 12/01/1998 - "Efficacy of a bioreactor filled with porcine hepatocytes immobilized on nonwoven fabric for ex vivo direct hemoperfusion treatment of liver failure in pigs." 01/01/2011 - "This study aims to evaluate the effectiveness of a hepatocyte bioreactor in the treatment of experimental post-hepatectomy liver failure. "
2.	Acute Liver Failure (Fulminant Hepatic Failure) 08/01/2003 - "The results obtained indicate that the bioreactor containing small liver fragments is effective in the treatment of acute hepatic failure in animals." 09/01/2003 - "The objective of this study was to evaluate the feasibility and safety of a hybrid liver support system with extracorporeal plasma separation and bioreactor perfusion in patients with acute liver failure (ALF) who had already fulfilled the criteria for high urgency liver transplantation (LTx). " 03/01/2002 - "Inclusion criteria for the study are patients with acute liver failure, any etiology, presenting with encephalopathy deteriorating beyond Parson's Grade 2. The BLSS consists of a blood pump; a heat exchanger to control blood temperature; an oxygenator to control oxygenation and pH; a bioreactor; and associated pressure and flow alarm systems. " 09/01/2011 - "Bioartificial liver system based on choanoid fluidized bed bioreactor improve the survival time of fulminant hepatic failure pigs." 01/01/2008 - "One of the most important challenges in bioartificial liver designed for patients suffering from acute liver failure is oxygenation of cells within the bioreactor. "
3.	Infection 11/01/1998 - "Subsequent studies focused on the infection, virus production and harvest from suspension culture bioreactors. " 10/13/2015 - "The synthetic strains were phenotypically identical to wild-type polioviruses as shown by equivalent infectious titers in culture supernatant and antigenic content, even when infection cultures are scaled up to 10-25L bioreactors. " 10/01/2015 - "Sf9 cells were maintained in the Wave Bioreactor system 20/50, and harvested when the viability decreased to 75% after infected with Bac-P1-3CD at the multiplicity of infection (MOI) of 1. After sonication and centrifugation, EV71 VLPs were purified with Capto(™) Core 700, Capto(™) adhere and Capto(™) butyl. " 08/01/2015 - "HEK293 cell cultivation, infection, and harvest of the virus (by lysing the cells inside the bioreactor) proved possible, reaching total yield of up to 1.6×10(14) viral particles (vp)/batch. " 03/01/2015 - "To assist process optimization, we studied Sabin type 1 poliovirus (PV) infection kinetics on Vero cells in controlled bioreactor vessels. "
4.	Neoplasms (Cancer) 01/10/2015 - "A 3D tension bioreactor platform to study the interplay between ECM stiffness and tumor phenotype." 05/15/2009 - "The simple to use bioreactor system provides an in vitro model that permits the study and manipulation of cancer cell interactions with bone tissue in real time. " 07/01/2005 - "The bioreactor also may serve as a unique model in which to study primary and metastatic cancers of bone." 03/01/1993 - "Prospects for use of microgravity-based bioreactors to study three-dimensional host-tumor interactions in human neoplasia." 01/01/1988 - "Tumor localization studies in athymic rats bearing human colon tumors were performed using the radioiodinated monoclonal antibody SP-21 and its F(ab')2. Antibody preparations isolated from ascitic fluid and antibody from bioreactor effluent were used in these studies with similar radioimmunolocalization results. "
5.	Hepatitis 01/01/2013 - "Our proof of concept of a scalable bioartificial liver modular device meets FDA guidelines and may function as an alternative model of animal experimentation for pharmacological and toxicological studies involving drug metabolism, enzyme induction, transplantation, viral hepatitis, hepatocyte regeneration, and can also be used in other existing bioreactor modules for long-term culture for up to 90 days or more." 05/01/1997 - "In hepatology, transplantation, and vaccination for hepatitides will increase, and improved treatment of acute liver failure may involve bioreactors or cryopreserved human hepatocytes. " 06/01/2003 - "TECA hybrid artificial liver support system (TECA-HALSS), which combines the hollow fiber bioreactor with a plasma exchange circuit, was used to assess the efficacy, safety and feasibility in treating severe hepatitis patients. " 10/05/1996 - "A xenogeneic hollow fiber bioreactor utilizing collagen-entrapped dispersed hepatocytes has been developed as an extracorporeal bioartificial liver (BAL) for potential treatment of acute human fulminant hepatitis. "

Related Drugs and Biologics

1.	glucuronyl glucosamine glycan sulfate (Vessel)
2.	Glucose (Dextrose)
3.	Vaccines
4.	Carbon Monoxide
5.	alginic acid (sodium alginate)
6.	Antigens
7.	Immunoglobulins (Immunoglobulin)
8.	Oxygen
9.	Glutamine (L-Glutamine)
10.	Glutamate-Ammonia Ligase (Glutamine Synthetase)

Related Therapies and Procedures

1.	Artificial Liver (Bioartificial Liver)
2.	Transplantation (Transplant Recipients)
3.	Hemoperfusion
4.	Bioreactors
5.	Oxygenators