Kinesin

A microtubule-associated mechanical adenosine triphosphatase, that uses the energy of ATP hydrolysis to move organelles along microtubules toward the plus end of the microtubule. The protein is found in squid axoplasm, optic lobes, and in bovine brain. Bovine kinesin is a heterotetramer composed of two heavy (120 kDa) and two light (62 kDa) chains. EC 3.6.1.-.

Networked: 380 relevant articles (2 outcomes, 38 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kozielski, Frank: 8 articles (06/2013 - 01/2007)
2.	Engle, Elizabeth C: 6 articles (04/2014 - 12/2003)
3.	Gallie, Brenda L: 6 articles (01/2014 - 02/2002)
4.	Corson, Timothy W: 5 articles (03/2014 - 09/2006)
5.	Mandi, Yvette: 5 articles (09/2009 - 01/2007)
6.	Somogyvari, Ferenc: 5 articles (09/2009 - 01/2007)
7.	Kondacs, Andras: 5 articles (09/2009 - 01/2007)
8.	Szolnoki, Zoltan: 5 articles (09/2009 - 01/2007)
9.	Chan, Wai-Man: 4 articles (04/2014 - 12/2003)
10.	Nakamura, Yusuke: 4 articles (08/2013 - 01/2005)

Related Diseases

1.	Myocardial Infarction 05/01/2010 - "The polymorphism Trp719Arg in the kinesin-like protein 6 is associated with the presence of late outgrowth endothelial progenitor cells in acute myocardial infarction." 01/01/2010 - "As a result of several genoms wide association studies the role of polymorphic marker Thr719Arg of kinesin 6 gene in development of ischemic heart disease, myocardial infarction, and in efficacy of therapy with statins was revealed." 01/29/2008 - "Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials."
2.	Prostatic Neoplasms (Prostate Cancer) 01/01/2012 - "The mitotic centromere-associated kinesin (MCAK) was identified as a novel mitosis-phase target in prostate cancer that was overexpressed in multiple CRPC gene-expression datasets. " 01/01/2012 - "Mitosis phase enrichment with identification of mitotic centromere-associated kinesin as a therapeutic target in castration-resistant prostate cancer." 09/15/2014 - "Nuclear Eg5 (kinesin spindle protein) expression predicts docetaxel response and prostate cancer aggressiveness." 09/01/2008 - "In this study, we sought to assess the efficacy of ispinesib, a mitotic kinesin spindle protein (KSP) inhibitor in androgen-independent prostate cancer progressing after docetaxel. " 01/01/2014 - "Microtubule-targeting agents such as taxanes, docetaxel and paclitaxel, have enjoyed success in the treatment of metastatic prostate cancer; although new, recently designed mitosis-specific agents, such as the polo-kinase and kinesin-inhibitors, have yielded clinically disappointing results. "
3.	Myocardial Ischemia (Ischemic Heart Diseases) 01/01/2010 - "As a result of several genoms wide association studies the role of polymorphic marker Thr719Arg of kinesin 6 gene in development of ischemic heart disease, myocardial infarction, and in efficacy of therapy with statins was revealed."
4.	Neoplasms (Cancer) 04/01/2015 - "First-in-human phase 1 study of filanesib (ARRY-520), a kinesin spindle protein inhibitor, in patients with advanced solid tumors." 08/01/2013 - "Phase II study to assess the efficacy, safety and tolerability of the mitotic spindle kinesin inhibitor AZD4877 in patients with recurrent advanced urothelial cancer." 11/01/2015 - "Kinesin superfamily protein 2A (KIF2A), an M‑type nonmotile microtubule depolymerase, has received attention for its role in carcinogenesis and prognostic value in several types of cancer. " 10/01/2015 - "There is emerging evidence that Kinesin family member 7 (Kif7) promotes Hedgehog (Hh) signaling during embryonic development, and its misregulation contributes to diseases such as ciliopathies and cancer. " 04/01/2015 - "Purpose Filanesib (ARRY-520) is a highly selective, targeted inhibitor of kinesin spindle protein (KSP) inhibitor that induces mitotic arrest and subsequent tumor cell death. "
5.	Breast Neoplasms (Breast Cancer) 01/01/2008 - "Among the dozens of transactivated genes, in the present study we focused on the functional significance of kinesin family member 2C (KIF2C)/mitotic centromere-associated kinesin (MCAK) in the growth of breast cancer cells. " 12/01/2015 - "To investigate the expression of targeting protein for Xenopus kinesin-like protein 2 (TPX2) in breast cancer tissue and to explore its role in proliferation, migration and invasion of breast cancer cells. " 10/01/2015 - "We investigated these questions using both a vesicular transport human kinesin, kinesin-1, and also a mitotic kinesin likely optimized for group function, kinesin-5, moving along either bovine brain or MCF7(breast cancer) MTs. " 01/01/2015 - "Impact of kinesin Eg5 inhibition by 3,4-dihydropyrimidin-2(1H)-one derivatives on various breast cancer cell features." 08/01/2014 - "Chemogenetic evaluation of the mitotic kinesin CENP-E reveals a critical role in triple-negative breast cancer."

Related Drugs and Biologics

1.	ispinesib
2.	docetaxel (Taxotere)
3.	Proteins (Proteins, Gene)
4.	Antigens
5.	Dyneins (Dynein)
6.	ARRY 520
7.	R-SNARE Proteins (Vesicle-Associated Membrane Protein)
8.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
9.	LDL Cholesterol
10.	4- (2,5- difluorophenyl)- N- (3- fluoro- 1- methylpiperidin- 4- yl)- 2- (hydroxymethyl)- N- methyl- 2- phenyl- 2,5- dihydro- 1H- pyrrole- 1- carboxamide

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Filtering Surgery
3.	Immunotherapy
4.	Heterologous Transplantation (Xenotransplantation)
5.	Therapeutics