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MicroRNAs (MicroRNA)

Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.
Also Known As:
MicroRNA; miRNA; miRNAs; Micro RNA; RNA, Micro; Primary MicroRNA; Primary miRNA; pre-miRNA; pri-miRNA; MicroRNA, Primary; Temporal RNA, Small; miRNA, Primary; pre miRNA; pri miRNA; RNA, Small Temporal; Small Temporal RNA; stRNA
Networked: 67212 relevant articles (1202 outcomes, 14225 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Zhang, Wei: 260 articles (11/2022 - 11/2008)
2. Croce, Carlo M: 248 articles (01/2022 - 11/2002)
3. Calin, George A: 223 articles (10/2022 - 07/2005)
4. Wang, Wei: 186 articles (08/2022 - 09/2007)
5. Wang, Jing: 177 articles (08/2022 - 04/2008)
6. Li, Jing: 169 articles (07/2022 - 01/2009)
7. Wang, Lei: 164 articles (04/2022 - 09/2009)
8. Li, Wei: 162 articles (12/2022 - 12/2005)
9. Zhang, Lei: 159 articles (05/2022 - 05/2012)
10. Wang, Yan: 157 articles (07/2022 - 01/2009)

Related Diseases

1. Neoplasms (Cancer)
2. Breast Neoplasms (Breast Cancer)
3. Inflammation (Inflammations)
4. Infections
5. Neoplasm Metastasis (Metastasis)

Related Drugs and Biologics

1. MicroRNAs (MicroRNA)
2. Biomarkers (Surrogate Marker)
3. Messenger RNA (mRNA)
4. Proteins (Proteins, Gene)
5. Pharmaceutical Preparations
6. Biological Products
7. Antagomirs
8. Long Noncoding RNA
9. Cytokines
10. RNA (Ribonucleic Acid)

Related Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Immunotherapy
4. Precision Medicine
5. Radiotherapy