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Fluocinonide (Lidex)

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A topical glucocorticoid used in the treatment of ECZEMA.

Also Known As:

Lidex; Bioglan Brand of Fluocinonide; Clariana Brand of Fluocinonide; Fluocinolone Acetonide 21-Acetate; Fluocinonide FAPG; Grünenthal Brand of Fluocinonide; Klariderm; Lidemol; Lyderm; Medicis Brand of Fluocinonide; Metosyn; Novoter; Optimapharma Brand of Fluocinonide; Syntex Brand of Fluocinonide; Teofarma Brand of Fluocinonide; Tiamol; Topsym; Topsyn; Topsyne; Yamanouchi Brand of Fluocinonide; Acetonide 21-Acetate, Fluocinolone; FAPG, Fluocinonide; Fluocinolone Acetonide 21 Acetate; Fluocinolide; Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-((1-methylethylidene)bis(oxy))-, (6alpha,11beta,16alpha)-

Networked: 74 relevant articles (15 outcomes, 18 trials/studies)

Relationship Network

Drug Context: Research Results

Polycyclic Compounds: 56
- Steroids: 18537
  - Fluorinated Steroids: 24
    - Fluocinolone Acetonide: 282
      - Fluocinonide: 74
        panthenol drug combination gentamicin fluocinonide betamethasone dipropionate: 1
  - Pregnanes: 3
    - Pregnadienes
      - Fluocinolone Acetonide: 282
        Fluocinonide: 74
        panthenol drug combination gentamicin fluocinonide betamethasone dipropionate: 1

Experts

1.	Feldman, Steven R: 3 articles (01/2014 - 01/2009)
2.	Draelos, Zoe Diana: 2 articles (08/2015 - 01/2008)
3.	Sandoval, Laura F: 2 articles (01/2014 - 10/2013)
4.	Gustafson, Cheryl J: 2 articles (01/2014 - 10/2013)
5.	Huang, Karen: 2 articles (01/2014 - 10/2013)
6.	Harrison, Jessica: 2 articles (01/2014 - 10/2013)
7.	O'Neill, Jenna L: 2 articles (01/2014 - 10/2013)
8.	Hix, Emily: 2 articles (01/2014 - 10/2013)
9.	Clark, Adele: 2 articles (01/2014 - 10/2013)
10.	Draelos, Zoe D: 1 article (08/2015)

Related Diseases

1.	Psoriasis (Pustulosis Palmaris et Plantaris) 11/01/1989 - "In a multicenter, evaluator-blind, parallel group study of 244 patients with moderate to severe psoriasis, a once-daily application of a new formulation of beta-methasone dipropionate 0.05% cream, augmented formulation (AF), and a twice-daily application of fluocinonide 0.05% cream were compared, with respect to safety and efficacy. " 07/01/1977 - "The study suggests that fluocinonide gel (0.05 percent) is a cosmetically acceptable alternative for the treatment of refractory psoriasis." 07/01/1977 - "Twenty patients with refractory psoriasis that had responded poorly to previous therapy were treated with fluocinonide gel (0.05 percent), unoccluded, for six weeks. " 07/01/1977 - "Treatment of refractory psoriasis with fluocinonide gel." 01/15/1974 - "The treatment of psoriasis with fluocinonide. "
2.	Atopic Dermatitis (Atopic Eczema) 09/01/2009 - "Once- or twice-daily topical application of fluocinonide 0.1% cream for 14 days was safe and effective for treating atopic dermatitis in this adult patient population. " 10/01/2010 - "Improvement in treatment adherence with a 3-day course of fluocinonide cream 0.1% for atopic dermatitis." 10/01/2010 - "The purpose of this study was to assess the efficacy, tolerability, and adherence to short-term treatment with fluocinonide cream 0.1% in the treatment of atopic dermatitis. " 12/01/2006 - "An open-label adrenal suppression study of 0.1% fluocinonide cream in pediatric patients with atopic dermatitis." 01/01/2014 - "Ten patients with mild to moderate atopic dermatitis applied topical fluocinonide 0.1% cream twice daily for 5 days. "
3.	Eczema 01/01/2008 - "This study evaluated the effect of both a multilamellar vesicular emulsion (MVE) ceramide-containing liquid cleanser and moisturizing cream plus fluocinonide cream 0.05% compared with a bar cleanser plus fluocinonide cream 0.05% in the treatment of mild to moderate eczema. " 07/25/1974 - "[Experience in the treatment of various forms of eczema with fluocinonide ointment (a doubleblind study and its statistical analysis) (author's transl)]." 09/01/1985 - "Both regimens were safe: drug-related side effects were generally mild and occurred most commonly with fluocinonide therapy in eczema patients. " 03/01/1972 - ""Metosyn" in psoriasis and eczema." 09/01/1985 - "In all three response categories in psoriasis, and in two of three in eczema, clobetasol was statistically significantly superior to fluocinonide (p less than 0.05-p less than 0.001). "
4.	Skin Diseases 01/01/1979 - "A trial with fluocinonide in recalcitrant dermatoses." 04/18/1980 - "[Treatment of dermatoses with Topsym polyvalent]." 04/14/1973 - "[Clinical effectiveness of fluocinonide in several skin diseases]." 10/01/1972 - "Fluocinonide: a new topical corticosteroid for psoriasis and other dermatoses." 01/01/1974 - "Fluocinonide in FAPG base: a review of its therapeutic efficacy in inflammatory dermatoses."
5.	Erythema 01/01/1985 - "Desoximetasone was significantly superior to fluocinonide in improving severity scores from baseline for thickening (days 7 and 14) and erythema (day 14); in numbers of subjects cleared of thickening (day 4); in overall evaluation ratings as compared to baseline (day 14); and in number of patients receiving an overall evaluation of excellent. " 05/01/1998 - "Fluocinonide had a significantly greater effect on erythema than tazarotene at weeks 2 through 8. However, treatments were not significantly different at week 12, and tazarotene demonstrated significantly better maintenance of therapeutic effect after cessation of therapy. " 11/01/1994 - "Mean scores for erythema in calcipotriene-treated subjects were significantly lower than those in fluocinonide-treated subjects at weeks 4 and 6 (p < 0.05). " 11/01/1989 - "Results significantly favored betamethasone dipropionate AF over fluocinonide, as indicated by improvements in signs of erythema, induration, and scaling, as well as the physicians' and patients' global evaluations of response after 14 days of treatment. " 05/01/1998 - "In one study in patients with psoriasis, tazarotene had similar efficacy to fluocinonide in reducing plaque elevation, but not erythema. "

Related Drugs and Biologics

1.	Fluocinonide (Lidex)
2.	Adrenal Cortex Hormones (Corticosteroids)
3.	Desoximetasone (Topicort)
4.	Coal Tar (Estar)
5.	Betamethasone (Celestone)
6.	Clobetasol (Clobetasol Propionate)
7.	Halcinonide (Dermalog)
8.	tazarotene (Tazorac)
9.	FAPG base
10.	Hydrocortisone (Cortisol)

Related Therapies and Procedures

1.	Phototherapy (Light Therapy)
2.	Photochemotherapy (Photodynamic Therapy)
3.	Occlusive Dressings (Occlusive Dressing)