Pregnanes

Saturated derivatives of the steroid pregnane. The 5-beta series includes PROGESTERONE and related hormones; the 5-alpha series includes forms generally excreted in the urine.

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Wiebe, John P: 1 article (03/2003)
2.	Lewis, Michael J: 1 article (03/2003)

Related Diseases

1.	Lordosis 12/01/1988 - "Lordosis facilitation in estrogen primed rats by intrabrain injection of pregnanes." 01/01/1986 - "Of the four pregnanes studied only 5 beta 3 beta pregnanolone consistently induced lordosis behavior when implanted into the mPOA. " 01/01/1986 - "The effect on lordosis behavior of progesterone (P) and some of its ring A reduced metabolites (5 beta pregnane 3 alpha ol 20 one, 5 beta pregnane 3 beta ol 20 one and 5 alpha pregnanes 3 beta ol 20 one) was studied in estrogen primed overiectomized rats by unilaterally implanting them in two brain areas related to the control of lordosis behavior: the ventromedial hypothalamic nucleus (VMH) and the medial preoptic area (mPOA). " 12/01/1988 - "The observation that lordosis was induced in estrogen primed rats both by pregnanes that bind to the P receptor (i.e., P; 5 alpha-pregnanedione; 20 alpha- and 20 beta-OH-pregnenone) and by pregnanes that do not (i.e., 5 alpha, 3 beta-; 5 beta,3 beta- and 5 alpha,3 alpha-pregnanolone) indicates that diverse cellular mechanisms are involved in the facilitation of lordosis by pregnanes."
2.	Neoplasms (Cancer) 03/22/2003 - "The findings provide the first evidence that the 5alphaR activity (leading to the conversion of progesterone to the cancer promoting 5alpha-pregnanes) is significantly higher in the tumorigenic MCF-7, MDA-MB-231 and T-47D breast cell lines than in the nontumorigenic MCF-10A cell line. "

Related Drugs and Biologics

1.	Progesterone
2.	Pregnanolone (Allopregnanolone)
3.	Estrogens (Estrogen)
4.	5-alpha-Dihydroprogesterone (5 alpha-Dihydroprogesterone)
5.	hydroxide ion