Clobetasol (Clobetasol Propionate)

A derivative of PREDNISOLONE with high glucocorticoid activity and low mineralocorticoid activity. Absorbed through the skin faster than FLUOCINONIDE, it is used topically in treatment of PSORIASIS but may cause marked adrenocortical suppression.

Also Known As:

Networked: 371 relevant articles (100 outcomes, 97 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Feldman, Steven R: 15 articles (01/2015 - 05/2002)
2.	Colón, Luz E: 7 articles (10/2011 - 11/2007)
3.	Koo, John Y M: 6 articles (02/2015 - 06/2002)
4.	Menter, Alan: 6 articles (02/2012 - 05/2002)
5.	Johnson, Lori A: 6 articles (10/2011 - 01/2008)
6.	Koo, John: 5 articles (09/2013 - 05/2002)
7.	Lebwohl, Mark: 5 articles (06/2008 - 05/2002)
8.	Gottschalk, Ronald W: 4 articles (11/2012 - 01/2009)
9.	Hudson, Charles P: 4 articles (10/2011 - 02/2011)
10.	Papp, Kim: 4 articles (10/2011 - 01/2010)

Related Diseases

1.	Psoriasis (Pustulosis Palmaris et Plantaris) 01/01/1987 - "Although it would appear that there was no clear preference for continuous therapy, other studies involving larger numbers of patients are needed to determine whether intermittent therapy with a potent corticosteroid such as clobetasol propionate is equally as effective in psoriasis." 06/01/2006 - "Clobetasol propionate is a very effective treatment for psoriasis. " 04/01/2006 - "Clobetasol propionate is known to be a very effective treatment for psoriasis; however, its use is limited by potent corticosteroid class related side effects such as hypothalamic-pituitary-adrenal (HPA) axis suppression and atrophogenicity. " 11/01/2012 - "When clobetasol propionate 0.05% spray was used as monotherapy or as an add-on therapy for 4 weeks in a large, observational trial, approximately 80% of patients experienced consistent and significant improvement in QOL on 2 separate, validated QOL instruments (DLQI and the Koo-Menter Psoriasis Index). " 11/01/2012 - "In another randomized trial in patients with moderate to severe plaque psoriasis, clobetasol propionate 0.05% spray produced significantly greater reductions in mean affected body surface area and significantly greater improvements in QOL, as measured by the Dermatology Life Quality Index (DLQI), compared with a 0.05% foam formulation. "
2.	Lichen Sclerosus et Atrophicus (Lichen Sclerosus) 09/01/1998 - "Clobetasol propionate cream is recommended for treatment of lichen sclerosus, with a 77% chance of complete remission of symptoms and a 47% chance of improvement in the clinical appearance of the vulva. " 03/01/1999 - "Treatment with clobetasol propionate 0.05% cream is effective against lichen sclerosus et atrophicus (LSA) of the vulva. " 09/01/1998 - "To assess the efficacy of treating lichen sclerosus with clobetasol propionate. " 07/01/2014 - "At the end of the study, 28 participants (19 tacrolimus and 9 clobetasol) still had some clinical signs of lichen sclerosus (χ(2) = 6.56, P = .015). " 03/01/1999 - "Penile lichen sclerosus et atrophicus treated with clobetasol dipropionate 0.05% cream: a retrospective clinical and histopathological study."
3.	Vulvar Lichen Sclerosus 10/01/2001 - "Clobetasol propionate was an effective treatment of premenarchal vulvar lichen sclerosus in this small group; however, recurrences were common and required additional steroid treatment. " 06/01/2004 - "To analyze the rates of remission, recurrence, and chronic evolution of vulvar lichen sclerosus (VLS) treated with 0.05% clobetasol propionate ointment and determine whether this treatment can decrease the risk of malignant evolution. " 01/01/2011 - "This study investigates the health-related quality of life in patients with vulvar lichen sclerosus (LS) and the patient-defined therapeutic benefit of clobetasol. " 01/01/2002 - "Clobetasol propionate 0.05% has been the mainstay in treating vulvar lichen sclerosus (VLS) for the past ten years. " 01/01/2002 - "Vulvar lichen sclerosus in postmenopausal women: a comparative study for treating advanced disease with clobetasol propionate 0.05%."
4.	Erythema 06/01/2002 - "Erythema improved significantly more in clobetasol-treated lesions (P <.05) during the treatment period, but differences became statistically insignificant during the post-treatment period (;P =.20). " 05/01/2003 - "At Week 2 (or end of treatment), 68% (94/139) of patients who received clobetasol foam had a Physician's Static Global Assessment score of 0 (clear, except for minor residual discoloration) or 1 (majority of lesions have individual scores for plaque thickness, erythema, and scaling that averages 1). " 11/01/2006 - "Overall, clobetasol propionate spray 0.05% administered twice daily for 4 weeks was effective and safe in reducing scaling, erythema, plaque elevation, and overall disease severity and demonstrates durable clinical response up to 4 weeks after treatment end." 01/01/2006 - "Clobetasol propionate shampoo was superior to tar blend shampoo with respect to all efficacy variables tested (p<0.001): Total and Global Severity Score; erythema; plaque thickening; desquamation; pruritus; total scalp area involved; and the subject's global assessment of clinical improvement. " 09/01/2006 - "At weeks 4, 6, and 8, significantly greater proportions of patients treated with tacrolimus had improved erythema and desquamation compared with those treated with clobetasol (all, P < 0.001). "
5.	Oral Lichen Planus 05/01/2011 - "A patient suffering from a mixed atrophic-erosive form of oral lichen planus (OLP), with serious gingival involvement, was also treated with the topical application of clobetasol propionate 0.05% using gingival trays. " 09/01/2010 - "HPA-suppressive effects of aqueous clobetasol propionate in the treatment of patients with oral lichen planus." 02/01/2009 - "Topical clobetasol in the treatment of atrophic-erosive oral lichen planus: a randomized controlled trial to compare two preparations with different concentrations." 01/01/1992 - "[Occlusive treatment of atrophic and erosive oral lichen planus with Clobetasol Propionate 0.05% ointment (Dermovat)]." 06/01/2014 - "Efficacy of laser phototherapy in comparison to topical clobetasol for the treatment of oral lichen planus: a randomized controlled trial."

Related Drugs and Biologics

1.	Tacrolimus (Prograf)
2.	mometasone furoate (mometasone)
3.	Adrenal Cortex Hormones (Corticosteroids)
4.	Clobetasol (Clobetasol Propionate)
5.	pimecrolimus (Elidel)
6.	calcipotriene (calcipotriol)
7.	Anthralin (Dithranol)
8.	tazarotene (Tazorac)
9.	Calcitriol (Calcijex)
10.	Testosterone (Sustanon)

Related Therapies and Procedures

1.	Hydrocolloid Bandages (Duoderm)
2.	Aftercare (After-Treatment)
3.	Excimer Lasers
4.	Drug Therapy (Chemotherapy)
5.	Low-Level Laser Therapy (LLLT)