Hydrocortisone (Cortisol)

The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.

Also Known As:

Networked: 15970 relevant articles (584 outcomes, 2052 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Yehuda, Rachel: 73 articles (01/2016 - 01/2002)
2.	Walker, Brian R: 44 articles (01/2016 - 02/2002)
3.	Kirschbaum, Clemens: 40 articles (11/2015 - 03/2002)
4.	Sasano, Hironobu: 37 articles (10/2015 - 07/2002)
5.	Stewart, Paul M: 34 articles (11/2015 - 01/2002)
6.	Chrousos, George P: 34 articles (05/2014 - 02/2002)
7.	Annane, Djillali: 30 articles (08/2013 - 01/2002)
8.	Andrew, Ruth: 29 articles (01/2016 - 07/2002)
9.	Stratakis, Constantine A: 28 articles (10/2015 - 06/2002)
10.	Allolio, Bruno: 25 articles (01/2016 - 01/2005)

Related Diseases

1.	Cushing Syndrome 05/01/2009 - "Sequential salivary cortisol measurements are also extremely helpful for the investigation of suspected cyclical Cushing's syndrome. " 01/01/2013 - "Because hypercortisolism symptoms are wide ranging, it is important to assess a variety of outcomes including both clinical factors, such as cortisol levels, and health-related quality of life (HR-QOL), to better understand the severity and impact of CD on patients and the potential efficacy of CD treatment. " 08/01/2014 - "A high prevalence of psychological morbidity and maladaptive personality as well as impaired quality of life (QoL) is observed in patients with and without hydrocortisone dependency following (cured) Cushing's syndrome. " 07/01/2013 - "Conversely, remission from hypercortisolism is followed by improvement in cardiovascular risk markers as intima-media thickness or arterial distensibility, suggesting a strong link between cortisol excess and adverse vascular remodeling. " 10/01/1995 - "Urinary free cortisol was also significantly greater in mild Cushing syndrome (540 +/- 50 nmol/d) than in patients with pseudo-Cushing states (430 +/- 41 nmol/d, p < 0.05) or normal volunteers (160 +/- 28 nmol/d, p < 0.0001). "
2.	Adrenal Insufficiency (Adrenal Gland Hypofunction) 02/01/2015 - "Two parameters were found to be significant predictors of remission after the first treatment: age at disease diagnosis and the development of adrenal insufficiency (cortisol <3 μg/dl) in the immediate post-operative state. " 10/01/2012 - "Adjunctive therapy with hydrocortisone is sometimes beneficial in the setting of catecholamine resistance and/or adrenal insufficiency. " 06/01/2005 - "Although all cured CD patients (Group I) presented serum cortisol level lower than 55 nmol/l until 72 h after surgery, none had significant complications related to adrenal insufficiency. " 06/01/2007 - "This study showed that a 60-minute cortisol value during SST was reliable enough in identifying normal subjects for excluding adrenal insufficiency, and was equally effective in identifying abnormal cases, as compared to values at both 30 and 60 minutes. " 07/01/2013 - "Salivary cortisol is a useful tool to assess endogenous cortisol excess or adrenal insufficiency and to evaluate stable CD in remission."
3.	Pain (Aches) 11/01/2008 - "Hair cortisol contents (median and range) were significantly greater in chronic pain patients (83.1: 33.0-205 g/mg) than in controls (46.1: 27.2-200 pg/mg) (P < 0.01). " 06/01/1983 - "We conclude that ultrasound with hydrocortisone is beneficial in relieving pain, relieving deviation, and reducing the size of the fibrous plaque. " 01/01/1998 - "Both methods were effective in reducing pain for tail docking [active behavioural responses reduced by more than 80% (P < or = 0.01) and abnormal postures by 56% (P < or = 0.01)], although local anaesthetic was more effective, reducing the peak cortisol by 60% (P < or = 0.01) [crushing by 44% (P > 0.05)]. " 06/01/2015 - "There was also an improvement in pain interference on general activity (P=0.035), mood (P=0.03) and work (P=0.04) following hydrocortisone compared with placebo. " 12/01/1996 - "An observational pain score and saliva for cortisol concentration were obtained 2, 8, and 24 hours after beginning treatment to compare efficacy of pain control. "
4.	Septic Shock (Toxic Shock Syndrome) 05/01/2008 - "Recent results from the CORTICUS study have not confirmed previous beneficial results and have led to restrictions in the use of hydrocortisone substitution therapy in patients with septic shock. " 12/01/1999 - "Two recent small randomized trials evaluating a 5- to 12-day course of low dose hydrocortisone in patients with septic shock have reported a significant clinical improvement and a reduction in mortality. " 04/01/1998 - "Administration of modest doses of hydrocortisone in the setting of pressor-dependent septic shock for a mean of >96 hrs resulted in a significant improvement in hemodynamics and a beneficial effect on survival. " 01/01/2003 - "Recently, a new concept has emerged with more promising results--low dose, long-term hydrocortisone therapy- and this approach is now being evaluated in the treatment of septic shock. " 07/01/2008 - "Is hydrocortisone an effective treatment for septic shock?"
5.	Neoplasms (Cancer) 03/01/2014 - "No significant relationship was found between preoperative 24-hour free urine cortisol and disease-free months or tumor volume among both groups. " 05/01/1996 - "We hypothesize that this is caused by increased metabolic clearance of cortisol due to increased utilization of metabolic substrates often observed in the presence of a tumor." 06/01/2015 - "This study provides preliminary evidence that cancer survivors with higher levels of dispositional mindfulness may be buffered from deleterious changes in cortisol secretion. " 06/01/2015 - "Findings indicated that cancer survivors who reported lower baseline levels of dispositional mindfulness exhibited increases in waking cortisol over time, whereas those who reported higher baseline dispositional mindfulness showed comparatively stable waking cortisol over the study period. " 06/01/2015 - "In the present study, we evaluated dispositional mindfulness as a predictor of changes in waking salivary cortisol levels among a sample of cancer survivors. "

Related Drugs and Biologics

1.	Adrenocorticotropic Hormone (ACTH)
2.	Dexamethasone (Maxidex)
3.	Insulin (Novolin)
4.	Hydrocortisone (Cortisol)
5.	Hormones
6.	Testosterone (Sustanon)
7.	Glucose (Dextrose)
8.	Steroids
9.	Aldosterone
10.	Epinephrine (Adrenaline)

Related Therapies and Procedures

1.	Adrenalectomy
2.	Drug Therapy (Chemotherapy)
3.	Enema (Enemas)
4.	Injections
5.	Radiotherapy