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Desoximetasone (Topicort)

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A topical anti-inflammatory glucocorticoid used in DERMATOSES, skin allergies, PSORIASIS, etc.

Also Known As:

Topicort; 17-Desoxymethasone; A-41304; Abbott Brand of Desoximetasone; Aventis Brand of Desoximetasone; Bipharma Brand of Desoximetasone; Dermik Brand of Desoximetasone; Desoxi; Flubason; Hoechst Brand of Desoximetasone; Ibaril; Medicis Brand of Desoximetasone; Optipharma Brand of Desoximetasone; Stiedex; Stiefel Brand of Desoximetasone; Topicorte; Topisolon; 17 Desoxymethasone; A 41304; A41304; Deoxydexamethasone; Desoxymethasone; Pregna-1,4-diene-3,20-dione, 9-fluoro-11,21-dihydroxy-16-methyl-, (11beta,16alpha)-

Networked: 32 relevant articles (5 outcomes, 7 trials/studies)

Relationship Network

Drug Context: Research Results

Polycyclic Compounds: 56
- Steroids: 18537
  - Fluorinated Steroids: 24
    - Dexamethasone: 13919
      - Desoximetasone: 32
  - Pregnanes: 3
    - Pregnadienes
      - Pregnadienediols
        Desoximetasone: 32

Experts

1.	Levitt, Jacob: 2 articles (11/2006 - 12/2003)
2.	Keegan, Brian Robert: 1 article (08/2015)
3.	Tolstykh, Olga: 1 article (06/2014)
4.	Slaga, Thomas J: 1 article (06/2014)
5.	Kowalczyk, Piotr: 1 article (06/2014)
6.	Sosnowska, Renata: 1 article (06/2014)
7.	Kowalczyk, Magdalena C: 1 article (06/2014)
8.	Walaszek, Zbigniew: 1 article (06/2014)
9.	Hanausek, Margaret: 1 article (06/2014)
10.	Junco, Jacob J: 1 article (06/2014)

Related Diseases

1.	Psoriasis (Pustulosis Palmaris et Plantaris) 01/01/1986 - "Responses based on clinical assessment in 123 patients showed that the desoximetasone gel formulation is a safe and effective treatment for psoriasis of the scalp. " 08/01/2015 - "Data from two Phase 3, double-blind, randomized, vehicle-controlled parallel studies were evaluated to determine the efficacy and safety of twice daily desoximetasone 0.25% spray for the treatment of plaque psoriasis. " 12/01/2013 - "Two Phase 3, double-blind, randomized, vehicle-controlled parallel studies evaluated the efficacy and safety of desoximetasone spray 0.25%, a super-potent topical corticosteroid, twice daily vs vehicle spray twice daily for 28 days in adult patients with moderate to severe plaque psoriasis. " 12/01/2013 - "Clinical study results of desoximetasone spray, 0.25% in moderate to severe plaque psoriasis." 08/01/2015 - "This demonstrates that desoximetasone 0.25% spray provided fast and effective relief of scaling in patients with plaque psoriasis affecting 10% to 86% of their BSA."
2.	Skin Diseases 10/01/1978 - "Desoxymethasone: a review of its pharmacological properties and therapeutic efficacy in the treatment of dermatoses." 03/01/1978 - "A new potent topical corticosteroid, desoximetasone, was clinically evaluated in several hundred patients with steroid-responsive dermatoses. " 01/01/1985 - "The efficacy and safety of betamethasone dipropionate glycol cream 0.05% and desoximetasone ointment 0.25% were compared in a randomized, double-blind study of 80 patients with resistant or severe corticosteroid-responsive dermatoses. " 01/01/1975 - "Topisolon (Desoximetasone) has been used under clinical conditions on 42 patients with acute and chronic dermatoses. "
3.	Erythema 01/01/1978 - "Final evaluation shows desoxymethasone cream to be significantly more active concerning reduction of erythema and overall improvement of lesions." 01/01/1985 - "Desoximetasone was significantly superior to fluocinonide in improving severity scores from baseline for thickening (days 7 and 14) and erythema (day 14); in numbers of subjects cleared of thickening (day 4); in overall evaluation ratings as compared to baseline (day 14); and in number of patients receiving an overall evaluation of excellent. " 11/01/2006 - "The combination of desoximetasone and tacrolimus ointment was superior to tacrolimus alone (P=.0002) in treating atopic dermatitis as measured by the summary of the scores for erythema, lichenification, pruritus, scaling/dryness, and oozing/crusting. "
4.	Atopic Dermatitis (Atopic Eczema) 03/01/1978 - "p1 percent) with desoximetasone emollient cream (0.25 percent) showed the new topical steroid to be clinically superior in the relief of moderate and severe inflammatory manifestations of psoriasis and atopic dermatitis. " 11/01/2006 - "Combination treatment with desoximetasone and tacrolimus offered increased efficacy and tolerability over tacrolimus alone in patients with atopic dermatitis." 11/01/2006 - "We aimed to evaluate the efficacy of twice-daily simultaneous application of desoximetasone and tacrolimus in the treatment of atopic dermatitis versus tacrolimus monotherapy. " 12/01/2003 - "The physical and chemical compatibility of desoximetasone ointment 0.25% and tacrolimus ointment 0.1%, both widely used to treat atopic dermatitis, were determined. " 11/01/2006 - "Desoximetasone 0.25% and tacrolimus 0.1% ointments versus tacrolimus alone in the treatment of atopic dermatitis."
5.	Pruritus (Itching) 08/01/2015 - "Desoximetasone 0.25% spray was effective with significant improvements in overall severity and was well tolerated, with dryness, irritation, and pruritus at the application site being the only reported adverse events occurring in >1% of patients, each of which occurred in less than 3% of patients. " 11/01/2006 - "Of note, pruritus at the application site was diminished in subjects treated with desoximetasone and tacrolimus together compared with tacrolimus alone (P=.04). " 11/01/2006 - "The combination of desoximetasone and tacrolimus ointment was superior to tacrolimus alone (P=.0002) in treating atopic dermatitis as measured by the summary of the scores for erythema, lichenification, pruritus, scaling/dryness, and oozing/crusting. "

Related Drugs and Biologics

1.	Fluocinonide (Lidex)
2.	Tacrolimus (Prograf)
3.	Betamethasone (Celestone)
4.	Glucose (Dextrose)
5.	hydrocortisone-17-butyrate (Locoid)
6.	Desoximetasone (Topicort)
7.	Hydrocortisone (Cortisol)
8.	Anthralin (Dithranol)
9.	Salicylic Acid (2 Hydroxybenzoic Acid)
10.	Urea (Carbamide)