Omeprazole (Esomeprazole)

A highly effective inhibitor of gastric acid secretion used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits the H(+)-K(+)-ATPase (H(+)-K(+)-EXCHANGING ATPASE) in the proton pump of GASTRIC PARIETAL CELLS.

Also Known As:

Networked: 3133 relevant articles (563 outcomes, 703 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Illueca, Marta: 21 articles (07/2015 - 03/2006)
2.	Tolia, Vasundhara: 14 articles (07/2015 - 11/2007)
3.	Armstrong, D: 14 articles (04/2013 - 02/2000)
4.	Stolte, M: 14 articles (07/2006 - 01/2000)
5.	Lundborg, Per: 13 articles (07/2015 - 03/2006)
6.	Traxler, Barry: 13 articles (07/2015 - 08/2004)
7.	Lind, Tore: 12 articles (01/2015 - 10/2004)
8.	Lanas, Angel: 12 articles (10/2014 - 05/2002)
9.	Sung, Joseph J Y: 12 articles (07/2014 - 12/2002)
10.	Talley, N J: 12 articles (11/2013 - 10/2000)

Related Diseases

1.	Gastroesophageal Reflux (GERD) 12/01/1995 - "In addition, studies also indicate that omeprazole is the most effective agent for the treatment of patients with GERD refractory to other treatments. " 01/01/1989 - "Several studies have clearly demonstrated that omeprazole is highly efficacious in the management of patients with gastro-oesophageal reflux disease. " 05/18/2011 - "This multicenter clinical trial demonstrated that with contemporary antireflux therapy for GERD, either by drug-induced acid suppression with esomeprazole or by LARS, most patients achieve and remain in remission at 5 years. " 07/01/2015 - "GERD symptom scores were significantly improved from baseline to the final week of the study in all of the treatment groups (P < 0.01) CONCLUSIONS:: In children ages 1 to 11 years with endoscopically proven GERD, esomeprazole (at daily doses of 5, 10, or 20 mg) was generally well tolerated. " 07/01/2015 - "GERD symptom scores were significantly improved from baseline to the final week of the study in all of the treatment groups (P < 0.01) CONCLUSIONS: In children ages 1 to 11 years with endoscopically proven GERD, esomeprazole (at daily doses of 5, 10, or 20 mg) was generally well tolerated. "
2.	Ulcer 01/01/1989 - "In conclusion, omeprazole 20 mg each morning was found to be safe and highly effective for treatment of gastric and prepyloric ulcer in Korean patients, producing a 98% healing rate. " 01/01/1989 - "The healing efficacy of omeprazole was assessed in 57 Korean patients with endoscopically-proven gastric (GU) and/or prepyloric (PPU) ulcers of at least 5 mm diameter. " 04/01/1999 - "Horses treated with omeprazole had significantly (P < 0.01) more improvement in ulcer scores at the end of the study compared with controls. " 11/01/2008 - "Both the extracts produced significant reduction in ulcer index (P < 0.05) in all the models and the results were comparable with that of omeprazole-treated group. " 06/01/2005 - "DG showed significant protection against CRU (68.37%), AL (88.87%), ASP (38.2%), PL (40.63%) and HST (63.15%) induced ulcer models, whereas standard drug omeprazole (OMZ) showed protection index of 83.86, 56.35, 70.31 and 84.21%, respectively in CRU, ASP, PL and HST models. "
3.	Duodenal Ulcer (Curling's Ulcer) 11/01/1992 - "It is concluded that omeprazole, even in the presence of adverse prognostic influences, results in significantly better healing of duodenal ulcer and relief from symptoms than H2-RA." 01/01/1994 - "As omeprazole is more effective than the H2-receptor antagonists in the acute treatment of duodenal ulcer, healing virtually all patients within 4 weeks (4), it may also be more effective in the maintenance treatment of duodenal ulcer disease. " 01/01/1989 - "Open studies using maintenance treatment with low-dose omeprazole suggest that such therapy is effective in keeping refractory duodenal ulcer healed." 03/01/1996 - "Omeprazole is less effective in healthy subjects than in patients with duodenal ulcers. " 07/01/1991 - "Omeprazole is effective and safe in the treatment of gastric and duodenal ulcers."
4.	Peptic Ulcer (Peptic Ulcers) 08/01/1999 - "Omeprazole triple therapy is highly effective in patients with active or healed peptic ulcer disease, and is well tolerated." 06/01/1990 - "It is concluded that omeprazole is highly effective in healing refractory peptic ulcers." 02/01/1987 - "It is therefore concluded that omeprazole is highly effective in healing refractory peptic ulcers and that omeprazole maintenance therapy may be useful for prevention of relapse. " 05/01/1998 - "Both standard and high doses of omeprazole are equally safe and effective regimens for the treatment of NSAID-induced gastroduodenal ulcers when anti-inflammatory treatment is not discontinued." 04/01/2012 - "Prophylaxis with omeprazole is effective for the prevention of gastroduodenal ulcers, maintenance of remission and alleviation of dyspeptic symptoms in NSAID recipients. "
5.	Heartburn (Pyrosis) 06/26/2000 - "Patients were assessed at weeks 2 and 4. The efficacy of omeprazole for the treatment of heartburn was determined mainly through the following diary card data: daily resolution of heartburn and complete resolution of heartburn every day during 1 week of treatment. " 01/01/1993 - "In two studies against omeprazole, no significant difference was found in healing rates, while a Scandinavian study demonstrated more prompt relief from heartburn. " 07/01/2014 - "Within the first 4 days, the proportion of subjects with heartburn-free days was significantly greater with esomeprazole 20 mg versus placebo. " 01/01/2012 - "The mean number of heartburn-free days by D7 was significantly greater in the omeprazole group: 3.7 ± 2.3 days vs. 3.1 ± 2.1 (p = 0.02). " 02/01/1993 - "Omeprazole also provided significantly greater relief from daytime heartburn, nighttime heartburn, and acid regurgitation, and was associated with decreased concomitant antacid use. "

Related Drugs and Biologics

1.	Ranitidine (Zantac)
2.	Amoxicillin (Wymox)
3.	lansoprazole (Prevacid)
4.	Omeprazole (Esomeprazole)
5.	Clarithromycin (Biaxin)
6.	pantoprazole (Protonix)
7.	rabeprazole (Aciphex)
8.	Proton Pumps (Proton Pump)
9.	Metronidazole (Metric)
10.	Cimetidine (Biomet)

Related Therapies and Procedures

1.	Fundoplication
2.	Intravenous Infusions
3.	Oral Administration
4.	Gastrectomy
5.	Aftercare (After-Treatment)