ectoATPase

found in human leukocytes; ecto-Mg-ATPase isolated from chicken; myoglein from rat

Also Known As:

ATPase, ecto; CD39-like 3 protein, human; CD39L1 protein, human; CD39L3 protein, human; ENTPD2 protein, human; ENTPD3 protein, human; NTPDase-3, human; NTPDase2; ecto-Mg-ATPase; ecto-adenosine triphosphatase; ecto-atpase; ecto-nucleotidase; ectonucleoside triphosphate diphosphohydrolase 3, human; myoglein

Networked: 103 relevant articles (0 outcomes, 14 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Acid Anhydride Hydrolases
      - Adenosine Triphosphatases: 8623
        ectoATPase: 103

Experts

1.	Sévigny, Jean: 17 articles (12/2021 - 11/2004)
2.	Robson, Simon C: 7 articles (08/2020 - 03/2006)
3.	Braganhol, Elizandra: 4 articles (12/2021 - 08/2009)
4.	Martín-Satué, Mireia: 4 articles (04/2021 - 12/2013)
5.	Laketa, Danijela: 3 articles (01/2022 - 11/2015)
6.	Lavrnja, Irena: 3 articles (01/2022 - 11/2015)
7.	Nedeljkovic, Nadezda: 3 articles (01/2022 - 11/2015)
8.	Pelletier, Julie: 3 articles (12/2021 - 08/2007)
9.	Csizmadia, Eva: 3 articles (08/2020 - 09/2017)
10.	Feldbrügge, Linda: 3 articles (08/2020 - 09/2017)

Related Diseases

1.	Neoplasms (Cancer) 04/22/2021 - "In stroma, NTPDase2 was identified exclusively at the tumor-myometrial junction but this expression was lost in tumors of invasive phenotype. " 04/22/2021 - "NTPDase2 was present in tumor epithelial EC cells, as in the non-pathological endometria, but the expression underwent changes in subcellular distribution and also tended to decrease with the tumor grade. " 06/01/2012 - "We have previously shown that NTPDase2 reconstitution dramatically increases tumor growth in vivo. " 11/15/1991 - "The resistance of SRBC to ATPo is not caused by a high ATPo degradation, because the ecto-ATPase activity of SRBC was much lower than in ATPo-resistant CTL OE4 cells and comparable with EL4 tumor cells, which were easily lysed by ATPo. " 04/22/2021 - "Our results point to NTPDase2 as a histopathological marker of tumor invasion in EC, with diagnostic relevance especially in cases of EC coexisting with other endometrial disorders, such as adenomyosis, which occasionally hampers the assessment of tumor invasion parameters."
2.	Inflammation (Inflammations) 05/01/1998 - "Levamisole was administered at two doses: high (2.5 mg/kg) and low (0.25 mg/kg), according to two schedules: a) at a single dose, simultaneously with carragenine, 24 h before or 24 h after induction of inflammation; the lymphocytes were collected five times every 24 h, and the activity of ecto-ATPase was determined; b) at four doses, every 24 h after carragenine injection; the lymphocytes were collected 120 h after the induction of inflammation. " 06/01/2012 - "Overexpression of NTPDase2 in gliomas promotes systemic inflammation and pulmonary injury." 06/01/2017 - "Disruption of TG neuronal ecto-nucleotidase expression and axonal terminal localization under certain circumstances such as chronic inflammation, oxidant stress, local constriction, and injury in trigeminal nerves may contribute to the pathogenesis of orofacial neuropathic pain." 08/01/2009 - "These data suggest that the ADP derived from NTPDase2 activity stimulates platelet migration to the tumor area and that NTPDase2, by regulating angiogenesis and inflammation, seems to play an important role in tumor progression. " 05/15/2006 - "CD39/ecto-NTPDase 1 (nucleoside triphosphate diphosphohydrolase 1) is an ecto-nucleotidase that influences P2 receptor activation to regulate vascular and immune cell adhesion and signalling events pivotal in inflammation. "
3.	Ischemia 05/01/1990 - "Our aim is to study the activity of ecto-adenosine triphosphatase in the heart damaged by ischemia. " 12/01/2012 - "Our results suggest that the ecto-ATPase activity of LLC-PK1 cells has the characteristics of a type 3 E-NTPDase which is inhibited by ischemia. " 03/01/2006 - "Ecto-nucleotidase biochemical activity of CD39 is lost at sites of acute vascular injury, such as in ischemia reperfusion and immune graft rejection. " 08/24/2012 - "Correspondingly, inhibition of ATP breakdown by addition of the selective ecto-ATPase inhibitor ARL67156 significantly reduced ischemia-induced apoptosis. " 08/24/2012 - "Addition of the soluble ecto-ATPase apyrase, enhancing ATP degradation, increased ischemia-induced caspase-3 cleavage. "
4.	Infections 05/01/2015 - "Inhibition of ecto-ATPase activities impairs HIV-1 infection of macrophages." 07/01/2011 - "These results indicate that ecto-nucleotidase plays an important role in the infection process caused by Leishmania amazonensis." 01/01/2017 - "Ecto-nucleotidase activity is involved in the infection process of Leishmania and various other parasites that enables modulation of host immune responses to promote disease progression. " 01/01/2017 - "Given the importance of the extracellular metabolism of these nucleotides during intracellular pathogen infections, this study evaluates the role of ecto-nucleotidase activity during Leishmania infantum (L. " 05/01/2015 - "Using three different non-related ecto-ATPase inhibitors-POM-1, ARL67156 and BG0-we showed that the inhibition of these macrophage and viral ecto-ATPase activities impairs HIV-1 infection. "
5.	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/01/1982 - "In the present studies, the properties of this ecto-nucleotidase were investigated in unhomogenized lymphocytes isolated from the blood of normal subjects and patients with chronic lymphocytic leukemia. " 01/01/1987 - "Cell membrane fluidity (CMF), Ig receptor expression and ecto-ATPase activity were investigated in lymphocytes from patients with chronic lymphocytic leukemia (CLL) and from healthy controls. " 11/01/1983 - "The kinetic properties of the ecto-ATPase of human peripheral blood lymphocytes and of chronic lymphatic leukemia cells."

Related Drugs and Biologics

1.	Adenosine Triphosphate (ATP)
2.	Enzymes
3.	5'-Nucleotidase (5' Nucleotidase)
4.	CD39 antigen
5.	Nucleotides
6.	triphosphoric acid (triphosphate)
7.	Purinergic P2 Receptors (ADP Receptor)
8.	Proteins (Proteins, Gene)
9.	Apyrase (ATP Diphosphatase)
10.	NG-Nitroarginine Methyl Ester (L-NAME)

Related Therapies and Procedures

1.	Therapeutics
2.	Oral Administration
3.	Electroacupuncture