Dyrk Kinases

PROTEIN KINASES that can phosphorylate aromatic amino acid residue TYROSINE as well as aliphatic amino acid residues SERINE and THREONINE.

Also Known As:

DYRK4A protein; DYRK4B protein; Kinases, Dyrk; Dual Specificity Protein Kinase Dyrk; Dual Specificity Tyrosine-Phosphorylation Regulated Kinase 1A; Dual Specificity Tyrosine-Phosphorylation Regulated Kinase 1B; Dual Specificity Tyrosine-Phosphorylation Regulated Kinase 2; Dual Specificity Tyrosine-Phosphorylation Regulated Kinase 3; Dual Specificity Tyrosine-Phosphorylation Regulated Kinase 4; Dual Specificity Tyrosine-Phosphorylation Regulated Kinases; Dual-Specificity Tyrosine-Phosphorylation Regulated Kinase 4A; Dual-Specificity Tyrosine-Phosphorylation Regulated Kinase 4B

Networked: 78 relevant articles (1 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Meijer, Laurent: 7 articles (12/2019 - 11/2012)
2.	Becker, Walter: 5 articles (10/2018 - 01/2014)
3.	Hwang, Yu-Wen: 5 articles (02/2014 - 10/2006)
4.	Sun, Xiulian: 4 articles (06/2021 - 03/2011)
5.	Bazureau, Jean-Pierre: 4 articles (10/2017 - 11/2012)
6.	Carreaux, François: 4 articles (10/2017 - 11/2012)
7.	Durieu, Emilie: 4 articles (10/2017 - 11/2012)
8.	Wegiel, Jerzy: 4 articles (02/2014 - 10/2006)
9.	Caligan, Thomas B: 3 articles (08/2021 - 01/2021)
10.	Onyenwoke, Rob U: 3 articles (08/2021 - 01/2021)

Related Diseases

1.	Insulin Resistance 12/27/2019 - "Dual-specificity tyrosine phosphorylation-regulated kinase 1A ameliorates insulin resistance in neurons by up-regulating IRS-1 expression."
2.	Down Syndrome (Down's Syndrome) 11/23/2023 - "In this study, we investigated the impact of Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Dyrk1A) overexpression, a gene associated with Down syndrome, on hippocampal neuronal deficits in mice. " 01/01/2019 - "To further investigate the mechanisms involved, we used a second transgenic mouse model overexpressing a single gene candidate for Down syndrome cognitive phenotypes, the dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A). " 01/15/2018 - "Traditionally, EGCG has been associated with the ability to reduce dual specificity tyrosine phosphorylation regulated kinase 1A activity, which is overexpressed in trisomy 21. " 02/01/2014 - "The gene encoding dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is located within the Down syndrome (DS) critical region of chromosome 21. " 01/01/2014 - "Substantial evidence implicates DYRK1A (dual specificity tyrosine-phosphorylation-regulated kinase 1A) as a candidate gene responsible for altered neuronal development and brain abnormalities in Down syndrome. "
3.	Dementia (Dementias) 01/01/2011 - "Recent studies indicate that the dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) gene, which is located on chromosome 21q22.2 and is overexpressed in Down syndrome (DS), may play a significant role in developmental brain defects and in early onset neurodegeneration, neuronal loss and dementia in DS. " 01/01/2022 - "Deregulation of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) plays a significant role in developmental brain defects, early-onset neurodegeneration, neuronal cell loss, dementia, and several types of cancer. " 01/01/2023 - "In this sense, recent studies indicate that the dual-specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) gene, which is located on chromosome 21q22.2 and overexpressed in Down syndrome (DS), may play a significant role in developmental brain disorders and early onset neurodegeneration, neuronal loss and dementia in DS and AD. "
4.	Leukemia 07/01/2008 - "Recent studies have shown that several pro-apoptotic kinases, including protein kinase C (PKC)delta, Abelson murine leukemia viral oncogene homolog 1 (c-Abl) and dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2), undergo nuclear-cytoplasmic shuttling in response to DNA damage. " 01/01/2016 - "Although the etiology of this higher risk of developing leukemia remains largely unclear, the recent identification of CRLF2 (cytokine receptor like factor 2) and JAK2 mutations and study of the effect of trisomy of Hmgn1 and Dyrk1a (dual-specificity tyrosine phosphorylation-regulated kinase 1A) on B-cell development have shed significant new light on the disease process. "
5.	Neoplasms (Cancer) 07/29/2020 - "In accordance with an involvement of DYRK kinases in the regulation of tumorigenic processes, an increasing number of research studies have been published in recent years showing either alterations of DYRK gene expression in tumor samples and/or providing evidence of DYRK-dependent mechanisms that contribute to tumor initiation and/or progression. " 02/01/2023 - "Dual-specificity tyrosine phosphorylation-regulated kinase 1B (DYRK1B) controls cell-cycle progression in cancer cells. " 08/01/2021 - "As DYRK1A (dual-specificity tyrosine phosphorylation-regulated kinase 1a) plays a role in the pathophysiology of a number of diseases including diabetes, cancer and neurodegeneration [2], [3], [4], the identification of DYRK1A inhibitors is of significant interest. " 12/17/2019 - "Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) hyperactivity has been linked to the development of a number of human malignancies. " 01/01/2017 - "Dual specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) has been reported as a tumor suppressor gene in different cancers. "

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	HMGN1 Protein (HMGN1)
3.	Cytokine Receptors (Cytokine Receptor)
4.	Protein Kinase C
5.	Clk dual-specificity kinases
6.	lorecivivint
7.	Protein Kinases (Protein Kinase)
8.	Calcineurin
9.	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Neoadjuvant Therapy