Neoadjuvant Therapy

Preliminary cancer therapy (chemotherapy, radiation therapy, hormone/endocrine therapy, IMMUNOTHERAPY, HYPERTHERMIA, INDUCED etc.) that is given before the main therapy.

Also Known As:

Chemoradiation Therapy, Neoadjuvant; Chemoradiation Treatment, Neoadjuvant; Chemoradiation, Neoadjuvant; Chemoradiotherapy, Neoadjuvant; Chemotherapy Treatment, Neoadjuvant; Chemotherapy, Neoadjuvant; Neoadjuvant Chemoradiation Therapies; Neoadjuvant Chemoradiation Treatments; Neoadjuvant Chemoradiations; Neoadjuvant Chemoradiotherapies; Neoadjuvant Chemotherapies; Neoadjuvant Chemotherapy Treatments; Neoadjuvant Radiation Therapies; Neoadjuvant Radiation Treatments; Neoadjuvant Radiations; Neoadjuvant Radiotherapies; Neoadjuvant Systemic Therapies; Neoadjuvant Systemic Treatments; Neoadjuvant Therapies; Neoadjuvant Treatments; Radiation Therapy, Neoadjuvant; Radiation Treatment, Neoadjuvant; Radiation, Neoadjuvant; Radiotherapy, Neoadjuvant; Systemic Therapy, Neoadjuvant; Systemic Treatment, Neoadjuvant; Therapy, Neoadjuvant; Therapy, Neoadjuvant Chemoradiation; Therapy, Neoadjuvant Radiation; Therapy, Neoadjuvant Systemic; Treatment, Neoadjuvant; Treatment, Neoadjuvant Chemoradiation; Treatment, Neoadjuvant Chemotherapy; Treatment, Neoadjuvant Radiation; Treatment, Neoadjuvant Systemic; Neoadjuvant Chemoradiation; Neoadjuvant Chemoradiation Therapy; Neoadjuvant Chemoradiation Treatment; Neoadjuvant Chemoradiotherapy; Neoadjuvant Chemotherapy; Neoadjuvant Chemotherapy Treatment; Neoadjuvant Radiation; Neoadjuvant Radiation Therapy; Neoadjuvant Radiation Treatment; Neoadjuvant Radiotherapy; Neoadjuvant Systemic Therapy; Neoadjuvant Systemic Treatment; Neoadjuvant Treatment

Networked: 28715 relevant articles (2386 outcomes, 5802 trials/studies)

Relationship Network

Therapy Context: Research Results

Therapeutics: 1190486
- Combined Modality Therapy: 4433
  - Neoadjuvant Therapy: 28715

Experts

1.	Loibl, Sibylle: 118 articles (02/2024 - 01/2006)
2.	Doki, Yuichiro: 110 articles (05/2024 - 09/2002)
3.	Untch, Michael: 103 articles (02/2024 - 04/2006)
4.	Boughey, Judy C: 99 articles (04/2024 - 09/2006)
5.	von Minckwitz, Gunter: 96 articles (11/2021 - 10/2002)
6.	Hunt, Kelly K: 91 articles (02/2024 - 01/2002)
7.	Pusztai, Lajos: 80 articles (04/2024 - 11/2002)
8.	Hortobagyi, Gabriel N: 80 articles (05/2023 - 01/2002)
9.	Denkert, Carsten: 75 articles (02/2024 - 01/2009)
10.	Kuerer, Henry M: 72 articles (04/2024 - 01/2002)

Related Diseases

1.	Neoplasms (Cancer) 11/28/2023 - "Surgical resection is the main driver to improving survival in resectable tumors, while neoadjuvant treatment based on chemotherapy (and radiotherapy) is the best option-treatment for a non-primally resectable disease. " 01/01/2023 - "It is highly desirable to develop neoadjuvant treatment paradigms that impart both tumor-targeting accuracy and protection against recurrence of resectable CRC. " 01/01/2022 - "The best treatment strategy for oesophageal cancer patients achieving a complete clinical response after neoadjuvant chemoradiation is a burning topic. " 09/15/2020 - "Therefore the question remains whether neoadjuvant chemotherapy or neoadjuvant radiochemotherapy is eliciting the best results in patients with GEJ cancer. " 01/01/2020 - "Triple Negative (TN) and Her2-type breast cancers benefited most from neoadjuvant chemotherapy with higher frequency of pCR. "
2.	Breast Neoplasms (Breast Cancer) 04/01/2022 - "Most patients with HER2-positive metastatic breast cancer (MBC) receive first-line treatment with anti-HER2 agents and have already received anti-HER2 therapy as adjuvant or neoadjuvant therapy in the local setting of their disease presentation. " 12/01/2021 - "DOP has superior efficacy over standard neoadjuvant chemotherapy in HER2-negative breast cancer, particularly in a highly sensitive subset of high-risk HR-positive/HER2-negative patients." 01/01/2021 - "The addition of HER2-targeted agents to neoadjuvant chemotherapy has dramatically improved pathological complete response (pCR) rates in early-stage, HER2-positive breast cancer. " 05/02/2020 - "Neoadjuvant chemotherapy (NACT) is standard first- line treatment for most women diagnosed with high-risk TNBC, HER2+, and locally advanced ER+ breast cancer. " 10/01/2019 - "Promising results have supported the enhanced efficiency of 3D ABUS in detecting the extent of breast cancer and assessing response to neoadjuvant chemotherapy, whereas its correlation with molecular subtypes of breast cancer is remarkable. "
3.	Rectal Neoplasms (Rectal Cancer) 01/01/2020 - "Further evidence is needed from randomized controlled trials to enable experts in the nerve-sparing surgical experiences and neoadjuvant therapy experience to advise on the best treatment strategies for the management of rectal cancer patients including those with possible positive nodes on pretreatment imaging." 06/10/2017 - "MRI is highly accurate in the primary staging of rectal cancer; however, it has not proven to be effective in re-staging, especially in complete response evaluation after neoadjuvant therapy. " 11/01/2014 - "When combined with appropriate neoadjuvant chemotherapy and total mesorectal excision, the treatment of rectal cancer has dramatically improved. " 12/01/2023 - "This study aimed to compare the efficacy of local excision (LE) and intersphincteric resection (ISR) in patients with locally advanced rectal cancer who achieved a significant or complete pathological response following neoadjuvant chemoradiotherapy. " 04/21/2023 - "In this study, we aimed to investigate the predictive efficacy of magnetic resonance imaging (MRI) radiomics features at different time points of neoadjuvant therapy for rectal cancer in patients with pathological complete response (pCR). "
4.	Stomach Neoplasms (Stomach Cancer) 03/01/2024 - "Clinical prediction models are needed to accurately predict the prognosis of patients with gastric cancer who have received neoadjuvant therapy and to determine the best treatment strategies. " 10/25/2018 - "Currently, four TRG standards can be used to evaluate the efficacy of neoadjuvant chemotherapy or translational therapy for primary gastric cancer, including Becker, Mandard, Ninomiya and Ryan, among which Ryan's 0-3 classification system is the most widely used. " 01/01/2022 - "The efficacy of neoadjuvant chemotherapy for advanced gastric cancer is not yet firmly confirmed, but the exciting results demonstrated in several clinical studies have led neoadjuvant chemotherapy as the important treatment methods in guidelines. " 02/10/2023 - "New strategy in hemorrhagic gastric cancer: A case report of complete pathological remission after neoadjuvant chemotherapy." 01/01/2022 - "Pathological complete remission of a locally advanced gastric cancer by neoadjuvant therapy "sandwich" regimen as SOXAP+ fluorescence laparoscopic surgery +SOXAP: Case report."
5.	Adenocarcinoma 01/01/2022 - "Based on findings from this case report, it appears that initial neoadjuvant therapy was not effective and radical surgery may be the best treatment for patients with hepatoid adenocarcinoma of the stomach." 01/01/2020 - "The best outcomes are associated with neoadjuvant chemotherapy (NAC) for small cell variants, while there is potential benefit with the use of NAC for squamous cell and adenocarcinoma variants." 01/01/2017 - "The efficacy of neoadjuvant chemoradiotherapy (NACRT) and subset of pancreatic ductal adenocarcinoma (PDAC) patients who are most likely to benefit from this strategy remain elusive. " 07/01/2016 - "In this study, the only factor associated with complete remission of rectal adenocarcinoma was the time between neoadjuvant therapy and surgery. " 06/01/2019 - "In a large, propensity-matched cohort, adjuvant chemotherapy was associated with significantly improved survival for patients with node-positive esophageal adenocarcinoma after neoadjuvant therapy and complete resection. "

Related Drugs and Biologics

1.	Cisplatin (Platino)
2.	Paclitaxel (Taxol)
3.	Docetaxel (Taxotere)
4.	Trastuzumab (Herceptin)
5.	Biomarkers (Surrogate Marker)
6.	N-acetyltalosaminuronic acid (NAT)
7.	Oxaliplatin (Eloxatin)
8.	Fluorouracil (Carac)
9.	Carboplatin (JM8)
10.	Capecitabine (Xeloda)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Radiotherapy
4.	Neoadjuvant Therapy
5.	Adjuvant Chemotherapy