Jagged-1 Protein

A serrate-jagged protein that functions as a ligand for NOTCH RECEPTORS. It may regulate CELL DIFFERENTIATION in HEMATOPOIESIS and PHYSIOLOGIC ANGIOGENESIS. Mutations in the Jagged-1 gene are associated with ALAGILLE SYNDROME 1.

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Networked: 201 relevant articles (4 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Miele, Lucio: 4 articles (01/2018 - 07/2008)
2.	Osipo, Clodia: 3 articles (01/2018 - 07/2008)
3.	Wyatt, Debra: 3 articles (01/2018 - 07/2008)
4.	Santini, Donatella: 3 articles (03/2015 - 03/2007)
5.	Taffurelli, Mario: 3 articles (03/2015 - 03/2007)
6.	Anant, Shrikant: 3 articles (04/2014 - 11/2011)
7.	Sansone, Pasquale: 3 articles (11/2010 - 03/2007)
8.	Storci, Gianluca: 3 articles (11/2010 - 03/2007)
9.	Banerjee, Sanjeev: 3 articles (03/2010 - 11/2006)
10.	Li, Yiwei: 3 articles (03/2010 - 11/2006)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/01/2018 - "High membrane JAGGED1 protein expression predicts poor overall cumulative survival in women with HER2+ breast cancer.Conclusions" 02/01/2016 - "Jagged 1 expression indicated shorter disease-free survival (DFS) (P = 0.040) and metastasis-free survival (P = 0.048) in lymph node-negative breast cancer for which it was the only independent predictor of DFS (multivariate analysis, P = 0.046). " 01/01/2018 - "Importantly, FYN enhanced NOTCH2 activation in basal type breast cancer cells through STAT5-mediated upregulation of Jagged-1 and DLL4 NOTCH ligands, thereby contributed to mesenchymal phenotypes. " 04/01/2016 - "High expression of Notch-1 and its ligand Jagged-1 correlates with poor prognosis in breast cancer. " 10/01/2014 - "Knockdown of Jagged 1 expression in breast cancer cells not only repressed norepinephrine-induced activation of the Notch pathway in cocultured endothelial cells but also evidently impaired the effects of norepinephrine on capillary-like sprout formation. "
2.	Inflammation (Inflammations) 03/11/2015 - "The current study suggests that MSC-mediated immune modulation involves the education and expansion of regulatory immune cells in a Jagged-1 dependent manner and provides the first report of the importance of Jagged-1 signalling in MSC protection against inflammation in vivo." 01/01/2023 - "The goal of our studies was to determine the role of Jagged-1 in the pathogen-free inflammation induced by OVA during allergic airway disease in mice. " 01/01/2023 - "Jagged-1 Reduces Th2 Inflammation and Memory Cell Expansion in Allergic Airway Disease." 10/01/2017 - "However, after in vivo intranasal sensitization and challenge with HDM, DC-specific Jagged 1 or Jagged 2 single- or double-deficient mice had eosinophilic airway inflammation and a TH2 cell activation phenotype that was not different from that in control littermates. " 03/11/2015 - "MSC, but not Jagged-1 knock down MSC, reduced pathology in a mouse model of allergic airway inflammation. "
3.	Neoplasm Metastasis (Metastasis) 10/06/2021 - "Activation of the Jagged-1/Notch/CXCR4 axis induced RCC metastasis. " 01/01/2013 - "Our results provide strong evidence that up-regulation of Jagged1-Notch1 signaling plays a role in PCa progression and metastasis and suggest that Jagged-1 and Notch-1 may be useful markers in distinguishing indolent and aggressive PCas." 02/15/2011 - "One NOTCH Further: Jagged 1 in Bone Metastasis." 01/01/2013 - "In the present study, we investigated the expression levels of Jagged-1 and Notch-1 in human prostate tumors and their associations with PCa progression and metastasis. " 06/28/2023 - "Jagged 1 Regulates The Proliferation and Metastasis of Human MDA-T68 Thyroid Cancer Cells."
4.	Stomach Neoplasms (Stomach Cancer) 04/01/2020 - "We used 6 human gastric cancer cell lines (SNU-1, SNU-5, SNU-16, NCI-N87, KATO- III and AGS), and demonstrated the chemosensitivity of APEX1 and Jagged-1 through the MTT assay and immunoblotting. " 04/01/2020 - "We investigated the clinical role of the molecular targets, APEX1 and Jagged-1, and the Apex1 - Jagged-1 cascade in gastric cancer cells. " 04/01/2020 - "Clinical Significance of Jagged-1 Activated by APEX1 as a Chemoresistance Factor in Advanced Gastric Cancer." 03/10/2015 - "These findings implicate that the IL-6/STAT3/Jagged-1/Notch axis may be a useful target and that combination of the Notch or STAT3 inhibitors with trastuzumab may prevent or delay clinical resistance and improve the efficacy of trastuzumab in gastric cancer. " 03/10/2015 - "Acquisition of resistance to trastuzumab in gastric cancer cells is associated with activation of IL-6/STAT3/Jagged-1/Notch positive feedback loop."
5.	Neoplasms (Cancer) 06/28/2023 - "Finally, Jagged 1 silencing inhibited the xenografted tumors in vivo. " 03/01/2022 - "Treatment with an anti-Jagged-1 antibody inhibited the Jagged-1/Notch signaling pathway in tumor cells and the microenvironment, delaying tumor recurrence. " 09/01/2015 - "Ki-67 index was obviously higher in cancer foci, while it was negatively correlated with Notch1 and Notch3 (all P<0.01) and positively correlated with Dll1 and Jagged 1 (all P<0.01). " 06/01/2012 - "In addition, Jagged 1 (JAG1) and hairy enhancer of split 1 gene expression correlated with the degree of tumor differentiation. " 12/01/2010 - "High levels of Jagged-1 are a common feature of ovarian tumors. "

Related Drugs and Biologics

1.	Trastuzumab (Herceptin)
2.	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
3.	Discoidin Domain Receptor 1
4.	Ligands
5.	Messenger RNA (mRNA)
6.	Proteins (Proteins, Gene)
7.	Interleukin-6 (Interleukin 6)
8.	Transcription Factors (Transcription Factor)
9.	MicroRNAs (MicroRNA)
10.	Cyclin D1

Related Therapies and Procedures

1.	Adjuvant Chemotherapy
2.	Therapeutics
3.	Drug Therapy (Chemotherapy)