HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Cyclin D1

Protein encoded by the bcl-1 gene which plays a critical role in regulating the cell cycle. Overexpression of cyclin D1 is the result of bcl-1 rearrangement, a t(11;14) translocation, and is implicated in various neoplasms.

Also Known As:

Proto-Oncogene Products bcl-1; Proto-Oncogene Protein bcl-1; bcl-1 Proto-Oncogene Products; bcl1 Proto-Oncogene Proteins; Proto Oncogene Products bcl 1; Proto Oncogene Protein bcl 1; Proto Oncogene Proteins c bcl 1; Proto-Oncogene Products, bcl-1; Proto-Oncogene Proteins, bcl-1; Proto-Oncogene Proteins, bcl1; bcl 1 Proto Oncogene Products; bcl 1 Proto Oncogene Proteins; bcl-1, Proto-Oncogene Protein; bcl1 Proto Oncogene Proteins; c bcl 1 Proteins; c-bcl-1, Proto-Oncogene Proteins; CCND1 Protein; PRAD1 Protein; Proto-Oncogene Proteins c-bcl-1; bcl-1 Proto-Oncogene Proteins; c-bcl-1 Proteins

Networked: 4720 relevant articles (81 outcomes, 658 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Pestell, Richard G: 57 articles (04/2015 - 04/2002)
2.	Aggarwal, Bharat B: 35 articles (01/2015 - 12/2002)
3.	Wang, Chenguang: 25 articles (06/2015 - 09/2004)
4.	Diehl, J Alan: 23 articles (03/2015 - 05/2002)
5.	Lisanti, Michael P: 22 articles (04/2015 - 05/2003)
6.	Albanese, Chris: 19 articles (07/2009 - 07/2002)
7.	Li, Zhiping: 18 articles (04/2015 - 09/2004)
8.	Safe, Stephen: 17 articles (01/2015 - 03/2003)
9.	Sutherland, Robert L: 17 articles (08/2011 - 01/2002)
10.	Landberg, Göran: 16 articles (08/2013 - 01/2002)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2014 - "This suggests that miR-206-based anti-cyclin D1 targeted therapy would be beneficial in cancers where cyclin D1 is overexpressed and contains a 3'-UTR. " 06/01/2013 - "However, patients with nodal stage cN2 whose tumors had high cyclin D1 expression treated with TPF had significantly greater OS (P = 0.025) and DMFS (P = 0.025) when compared with high cyclin D1 cN2 patients treated with surgery upfront. " 01/01/2012 - "The delay in time to tumor corresponded with a significant reduction in cyclin D1 protein expression in the tumors. " 05/01/2003 - "The overexpression of cyclin D1 was found to be inversely related to disease-free interval (p < 0.001) and to the spindle A/B tumors with good prognosis (p = 0.05). " 08/01/2002 - "Conversely, lack of cyclin D1 expression results in significant reduction in mouse skin and mammary tumor development. "
2.	Breast Neoplasms (Breast Cancer) 08/18/2004 - "We have shown that Pin1 ablation is highly effective in preventing oncogenic Neu or Ras from inducing cyclin D1 and breast cancer in mice, although it neither affects transgene expression nor mammary gland development. " 09/06/2006 - "Cyclin D1 repression of STAT3 expression may explain the association between cyclin D1 overexpression and improved outcome in breast cancer. " 09/06/2006 - "Cyclin D1 is frequently overexpressed in breast cancer, and its overexpression is, surprisingly, associated with improved survival. " 04/20/2015 - "We initiated the following study to directly test the oncogenic potential of catalytically inactive cyclin D1 in an in vivo mouse model that is relevant to breast cancer. " 01/01/2015 - "Statin-induced anti-proliferative effects via cyclin D1 and p27 in a window-of-opportunity breast cancer trial."
3.	Retinoblastoma (Glioblastoma, Retinal) 09/01/2015 - "The aim of the present study was to investigate cell cycle markers p-16, cyclin D1, CDK4, E2F, and retinoblastoma (Rb) in this context. " 07/01/2004 - "Further immunoprecipitation studies found that, in response to the treatment, the formation of cyclin D1/cdk 4 complex declined, preventing the phosphorylation of retinoblastoma (Rb) and the subsequent dissociation of Rb/E2F complex. " 05/01/2015 - "Following further examination of cell cycle-related factors, MCM2 knockdown inhibited protein retinoblastoma (Rb), cyclin D1 and CDK4 expression, but increased p21 and p53 expression, suggesting that siMCM2 indeed triggered cell cycle arrest. " 02/01/2014 - "PK properties were similar to prior publications, and immunohistochemical staining for cyclin D1 and phospho-retinoblastoma did not predict response. " 09/15/2012 - "Cell cycle was arrested at the G1 phase and the expression of CDK4, cyclin D1, and phosphorylated retinoblastoma (pRb) was decreased. "
4.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 09/01/2003 - "Assessment of p16, cyclin D1, and pRB expression may be helpful for determining postoperative therapeutic strategies in patients with esophageal squamous cell carcinoma." 01/01/2014 - "Intravenous delivery of a chemically modified cyclic STAT3 decoy oligonucleotide with improved serum and thermal stability demonstrated antitumor efficacy in conjunction with downmodulation of STAT3 target gene expression such as cyclin D1 and Bcl-X(L) in a mouse model of head and neck squamous cell carcinoma. " 08/01/2015 - "The objective of this study was to examine the expression of TC1 and investigate the associations among TC1, β-catenin, Chibby, cyclin D1, and the clinicopathological factors of oral tongue squamous cell carcinomas (OTSCCs). " 01/01/2015 - "Studies examining the association between the cyclin D1 (CCND1) A870G (rs9344 G>A) polymorphism and esophageal squamous cell carcinoma (ESCC) have yielded inconsistent results. " 05/01/2014 - "The objective of the present study was to evaluate the expression of cyclin D1 in normal oral mucosa of both non tobacco habituated and tobacco habituated individuals histologically and also compare and correlate cyclin D1 expression with histopathologically confirmed cases of oral squamous cell carcinomas. "
5.	Neoplasm Metastasis (Metastasis) 03/01/2011 - "The purpose of the present study was to analyze the relationship between pathological parameters including invasion depth and lymph node metastasis and the expressions of β-catenin, c-myc, and cyclin D1 in order to evaluate their values of prognosis in patients with ESCC. " 01/01/2011 - "The parameters analyzed in the study included lymph node metastases, perineural invasion, differentiation, duodenal invasion, grade of intraepithelial neoplasia and p16 and cyclin D1 expression in tumoral and peritumoral pancreatic tissues. " 09/01/2010 - "In this study, we present a novel prediction system for the lymph node metastasis based on the histological and cyclin D1 staining features. " 01/01/2007 - "The aim of this study is to analyze the association of the Cyclin D1 as a risk factor for the presence of cervical metastasis. " 10/01/2015 - "β-Catenin, c-Myc, and cyclin D1 were downregulated after SFRP1 restoration, which suggested that SFRP1 suppressed growth and metastasis by inhibiting the Wnt/β-catenin signaling pathway in NPC. "

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	Cyclins
3.	Cyclin D3
4.	Retinoblastoma Protein
5.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
6.	Proteins (Proteins, Gene)
7.	Messenger RNA (mRNA)
8.	DNA (Deoxyribonucleic Acid)
9.	NF-kappa B (NF-kB)
10.	Matrix Metalloproteinase 9 (Gelatinase B)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Drug Therapy (Chemotherapy)
3.	Chemoprevention
4.	Oral Administration
5.	Intraperitoneal Injections