Adjuvant Chemotherapy

Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.

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Networked: 10255 relevant articles (930 outcomes, 2099 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Shariat, Shahrokh F: 33 articles (11/2015 - 10/2006)
2.	Karakiewicz, Pierre I: 29 articles (07/2015 - 10/2006)
3.	Hortobagyi, Gabriel N: 28 articles (03/2015 - 01/2002)
4.	Shepherd, Frances A: 26 articles (06/2015 - 02/2003)
5.	Yoshikawa, Takaki: 25 articles (12/2015 - 08/2010)
6.	Lotan, Yair: 25 articles (07/2015 - 10/2006)
7.	Benson, Al B: 24 articles (01/2015 - 06/2002)
8.	Goldberg, Richard M: 23 articles (12/2015 - 04/2002)
9.	Maehara, Yoshihiko: 23 articles (11/2015 - 12/2002)
10.	Mayer, Robert J: 22 articles (11/2015 - 02/2002)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2012 - "Despite a large number of clinical trials having been conducted to assess the efficacy of adjuvant chemotherapy after surgery for various cancers, whether it is best to use this treatment remains a generally contentious issue for many common cancers. " 10/01/2013 - "The excellent outcome now expected for most children with this tumor is attributed to the combination of effective adjuvant chemotherapy, improved surgical and anesthetic techniques and also the radiosensitivity of the tumor. " 01/01/2001 - "Adjuvant chemotherapy may prove effective in reducing the postoperative recurrence but at this stage surgery still remains as the best treatment for patients with recurrent tumor which is accessible to resection." 01/01/2000 - "The adjuvant chemotherapy performance was most effective in cancer stage III and in nondifferentiated type of tumor." 10/29/1991 - "The chances to be cured from a primary malignant musculoskeletal tumor have improved dramatically during the last two decades with the introduction of adjuvant chemotherapy. "
2.	Breast Neoplasms (Breast Cancer) 01/01/1990 - "Adjuvant chemotherapy is a well accepted concept in the treatment of breast cancer and has resulted in most clinical studies in a significant prolongation of the disease-free interval in certain subgroups of patients. " 06/10/2015 - "A supervised, moderate- to high-intensity, combined resistance and aerobic exercise program is most effective for patients with breast cancer undergoing adjuvant chemotherapy. " 01/01/2006 - "Systemic adjuvant chemotherapy has dramatically improved the outcome of patients treated for early stage invasive breast cancer. " 12/01/2005 - "Adjuvant chemotherapy is most cost-effective in pre-menopausal women with node-positive breast cancer while cost-effectiveness decreases considerably with increasing age. " 01/01/2012 - "Neoadjuvant chemotherapy is associated with improved survival compared with adjuvant chemotherapy in patients with triple-negative breast cancer only after complete pathologic response."
3.	Neoplasm Metastasis (Metastasis) 11/01/2014 - "Adjuvant chemotherapy was highly effective against local relapses [HR = 0.73; 95% confidence interval (CI) 0.60-0.90; P = 0.003] and nonbrain metastases (HR = 0.79; 95% CI 0.66-0.94; P = 0.008) but not against brain metastases (HR = 1.1; 95% CI 0.82-1.4; P = 0.61). " 11/01/2011 - "Adjuvant chemotherapy with S-1 resulted in complete remission of lung metastases. " 01/01/2004 - "Neoadjuvant or adjuvant chemotherapy did not provide a significant survival advantage, although adjuvant chemotherapy improved the 5-year overall survival in patients with pathologically proven lymph node metastasis. " 03/01/2015 - "Aggressive cytoreductive surgery with multiorgan resection, peritonectomy, HIPEC and adjuvant chemotherapy which was proved to be a feasible option in some patients, with synchronous liver resection (LR) proved to be feasible and beneficial for patients with three or fewer liver metastases. " 05/01/2014 - "Adjuvant chemotherapy significantly improved RFS (P = 0.002) and CSS (P = 0.001) in patients with lymph node metastasis. "
4.	Stomach Neoplasms (Stomach Cancer) 11/01/2012 - "Thus, research efforts should focus on which regimens are the most effective for patients with recurrent gastric cancer after combined treatment with surgery and perioperative or adjuvant chemotherapy. " 05/01/2012 - "The peritoneum is still the most frequent site of recurrence in stage II/III gastric cancer patients, although the survival rate was improved by the introduction of S-1 adjuvant chemotherapy. " 11/01/2000 - "Furthermore, the efficacy of adjuvant chemotherapy after curative resection for gastric cancer was warranted by a meta-analysis of 19 published randomized trials. " 07/01/2000 - "Efficacy of adjuvant chemotherapy after curative resection for gastric cancer: a meta-analysis of published randomised trials. " 10/01/2012 - "Adjuvant chemotherapy with S-1 was proven to be effective in Japanese patients with advanced gastric cancer curatively resected with D2 lymph node dissection. "
5.	Colonic Neoplasms (Colon Cancer) 11/01/2010 - "Stage III disease patients with colon cancer experienced the largest improvement in survival, most likely related to the increased administration of adjuvant chemotherapy." 02/01/2001 - "We conclude that resection alone is a highly effective treatment for T3N0 colon cancer leaving limited opportunity for adjuvant chemotherapy to significantly impact survival. " 09/01/2015 - "There is strong evidence supporting the efficacy of adjuvant chemotherapy for patients with pathologic, stage III colon cancer. " 01/01/2015 - "In this retrospective analysis, we aimed to evaluate the survival of patients with low-risk stage II colon cancer, the efficacy of adjuvant chemotherapy in high-risk stage II colon cancer patients, and prognostic factors in stage II disease. " 11/07/2014 - "Adjuvant chemotherapy significantly reduces mortality in stage III colon cancer; however, it is only marginally effective in stage II patients. "

Related Drugs and Biologics

1.	Fluorouracil (Carac)
2.	Cisplatin (Platino)
3.	Doxorubicin (Adriamycin)
4.	Cyclophosphamide (Cytoxan)
5.	Tegafur
6.	Leucovorin (Folinic Acid)
7.	Hormones
8.	oxaliplatin (Eloxatin)
9.	Methotrexate (Mexate)
10.	Paclitaxel (Taxol)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Radiotherapy
3.	Lymph Node Excision (Lymph Node Dissection)
4.	Cystectomy
5.	Combination Drug Therapy (Combination Chemotherapy)