Prostaglandin-E Synthases

Oxidoreductases that catalyze the GLUTATHIONE-dependent oxidoreduction of PROSTAGLANDIN H2 to PROSTAGLANDIN E2.

Also Known As:

Cytosolic Prostaglandin E2 Synthase; Endoperoxide Isomerase; PGE2 Isomerase; PGE2 Synthase; PGR2 E-Isomerase; PTGES2 Protein; PTGES3 Protein; Prostaglandin E Isomerase; Prostaglandin E Synthase; Prostaglandin E Synthase 1; Prostaglandin E Synthase 2; Prostaglandin E Synthase 3; Prostaglandin E Synthase-1; Prostaglandin E Synthases; Prostaglandin E2 Synthase; Prostaglandin Endoperoxide E Isomerase; Prostaglandin H2 E-Isomerase; Prostaglandin H2-Prostaglandin E2 Isomerase; Prostaglandin R2 E-Isomerase; Prostaglandin-E Synthase; E Synthases, Prostaglandin; Isomerase, Endoperoxide; Isomerase, PGE2; Isomerase, Prostaglandin E; PGR2 E Isomerase; Prostaglandin H2 E Isomerase; Prostaglandin H2 Prostaglandin E2 Isomerase; Prostaglandin R2 E Isomerase; Synthase, PGE2; Synthase, Prostaglandin E; Synthase, Prostaglandin E2; Synthase, Prostaglandin-E; Synthases, Prostaglandin E; Synthases, Prostaglandin-E

Networked: 351 relevant articles (7 outcomes, 25 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Isomerases: 467
    - Intramolecular Oxidoreductases
      - Prostaglandin-E Synthases: 351
        human PTGES protein
        human PTGES2 protein
        human PTGES3 protein
        mouse Ptges protein
        mouse Ptges2 protein
        mouse Ptges3 protein
        rat Ptges protein
        rat ptges3 protein
        zebrafish ptges protein
        zebrafish ptges3a protein

Experts

1.	Jakobsson, Per-Johan: 30 articles (01/2023 - 10/2002)
2.	Uematsu, Satoshi: 17 articles (01/2020 - 06/2004)
3.	Akira, Shizuo: 16 articles (01/2020 - 06/2004)
4.	Korotkova, Marina: 15 articles (01/2023 - 11/2005)
5.	Larsson, Karin: 9 articles (01/2023 - 06/2015)
6.	Nakatani, Yoshihito: 9 articles (03/2021 - 05/2003)
7.	Idborg, Helena: 7 articles (01/2023 - 04/2013)
8.	Kogner, Per: 7 articles (01/2023 - 10/2008)
9.	Hara, Shuntaro: 7 articles (03/2021 - 12/2009)
10.	Murakami, Makoto: 7 articles (03/2018 - 05/2003)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "Analyzing Cancer Genome Atlas (TCGA) data, we found that high NK cell gene signatures correlate with significantly improved overall survival in patients with high levels of the prostaglandin E synthase (PTGES). " 12/30/2021 - "Epithelial Cell-specific Deletion of Microsomal Prostaglandin E Synthase-1 Does Not Influence Colon Tumor Development in Mice." 02/01/2014 - "We have previously reported that host stromal microsomal prostaglandin E synthase-1 (mPGES-1) appeared critical for tumor-associated angiogenesis and tumor growth. " 10/01/2013 - "Genetic deletion of microsomal prostaglandin E synthase-1 suppresses mouse mammary tumor growth and angiogenesis." 12/15/2012 - "Human microsomal prostaglandin E synthase-1 (mPGES-1) is an emerging drug target for inflammatory disorders and cancer suppression. "
2.	Inflammation (Inflammations) 10/31/2018 - "Augmented liver inflammation in a microsomal prostaglandin E synthase 1 (mPGES-1)-deficient diet-induced mouse NASH model." 01/01/2018 - "Invalidation of Microsomal Prostaglandin E Synthase-1 (mPGES-1) Reduces Diet-Induced Low-Grade Inflammation and Adiposity." 11/18/2022 - "The present results integrate the previously observed inhibitory profile of the tested compounds against another MAPEG member, i. e., microsomal prostaglandin E2 synthase (mPGES)-1, suggesting that the 2,4-dinitro-biphenyl scaffold is a suitable molecular platform for a multitargeting approach to modulate pro-inflammatory mediators in inflammation and cancer treatment." 01/22/2017 - "Transcriptional regulation of microsomal prostaglandin E synthase 1 by the proto-oncogene, c-myc, in the pathogenesis of inflammation and cancer." 08/01/2011 - "Variants of gene for microsomal prostaglandin E2 synthase show association with disease and severe inflammation in rheumatoid arthritis."
3.	Carcinogenesis 01/01/2005 - "The goal of this study was to further define the role microsomal prostaglandin E synthases (mPGES-1) play in lung tumorigenesis. " 03/01/2021 - "Gene Deletion of Microsomal Prostaglandin E Synthase-1 Suppresses Chemically Induced Skin Carcinogenesis." 06/14/2012 - "Microsomal prostaglandin E synthase-1 is involved in multiple steps of colon carcinogenesis." 05/23/2003 - "Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis." 07/01/2010 - "In consideration that microsomal prostaglandin E synthase 1 (mPGES-1) is one of the most strategic target involved both in inflammation and in carcinogenesis processes, we decided to explore the biological effects of some structural changes of the gamma-hydroxybutenolide 2, hoping to improve its biological profile. "
4.	Pain (Aches) 07/22/2003 - "Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase." 06/01/2012 - "Microsomal prostaglandin E synthase-1 (mPGES-1) represents an attractive target for the treatment of rheumatoid arthritis and pain, being upregulated in response to inflammatory stimuli. " 04/11/2011 - "Microsomal prostaglandin E synthase-1 enhances bone cancer growth and bone cancer-related pain behaviors in mice." 09/01/2008 - "MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation." 10/30/2019 - "A multicenter, randomized, double-blind, placebo- and active-controlled study was conducted in client-owned dogs with moderate OA pain to evaluate efficacy of LYA, an inhibitor of microsomal prostaglandin E synthase-1 (mPGES1), an EP4 antagonist (LYB), and carprofen, versus placebo. "
5.	Infections 01/01/2019 - "Furthermore, inflamed adrenal microenvironment may tune the production of intracellular mediators that also operate upon GC synthesis, like PGE2 synthase and EPAC2, as emerging driving forces for GC production in the advanced course of Tc infection. " 11/01/2014 - "We also reflect on the potential beneficial action of microsomal prostaglandin E synthase-1 inhibitory compounds in the treatment of IAV infections and potentially other RNA viruses. " 11/24/2008 - "To verify a role for PGE(2) in control of bacterial growth, we show that infection of prostaglandin E synthase (PGES)(-/-) macrophages in vitro with H37Rv resulted in significantly higher bacterial burden compared with wild-type macrophages. " 04/17/2014 - "Targeted PGE2 suppression via genetic ablation of microsomal prostaglandin E-synthase 1 (mPGES-1) or by the pharmacological inhibition of PGE2 receptors EP2 and EP4 substantially improved survival against lethal IAV infection whereas PGE2 administration reversed this phenotype. " 10/01/2008 - "Here we evaluated whether the blood concentrations of PGE(2) and the gene transcription profiles of enzymes involved in its synthesis (cyclooxygenase-2 and prostaglandin E synthase) could be used as markers of predisposition and/or presence of puerperal uterine infections. "

Related Drugs and Biologics

1.	Dinoprostone (PGE2)
2.	Cyclooxygenase 2 (Cyclooxygenase-2)
3.	Prostaglandins
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
5.	Enzymes
6.	Cytokines
7.	Interleukin-6 (Interleukin 6)
8.	carprofen
9.	Prostaglandin E Receptors (Prostaglandin E Receptor)
10.	Metalloproteases (Metalloproteinases)

Related Therapies and Procedures

1.	Therapeutics
2.	Chemoprevention
3.	Injections
4.	Immunotherapy
5.	Hepatectomy