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Cyclooxygenase 2 (Cyclooxygenase-2)

Subscribe to New Research on Cyclooxygenase 2

An inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and INFLAMMATION. It is the target of COX2 INHIBITORS.

Also Known As:

Cyclooxygenase-2; COX-2 Prostaglandin Synthase; Cyclo-Oxygenase II; PGHS-2; PTGS2; Prostaglandin H Synthase-2; COX 2 Prostaglandin Synthase; Cyclo Oxygenase II; Prostaglandin H Synthase 2; Prostaglandin Synthase, COX-2; Synthase, COX-2 Prostaglandin

Networked: 6400 relevant articles (154 outcomes, 839 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Multienzyme Complexes: 7
    - Prostaglandin-Endoperoxide Synthases: 5248
      - Cyclooxygenase 2: 6400
        human PTGS2 protein
        mouse Ptgs2 protein
        rat Ptgs2 protein

Experts

1.	Ogino, Shuji: 29 articles (09/2015 - 01/2006)
2.	Fuchs, Charles S: 29 articles (09/2015 - 01/2006)
3.	Surh, Young-Joon: 29 articles (10/2014 - 01/2002)
4.	Dannenberg, Andrew J: 24 articles (01/2014 - 05/2002)
5.	Ristimäki, Ari: 24 articles (09/2012 - 02/2002)
6.	Dubinett, Steven M: 21 articles (07/2011 - 12/2002)
7.	Nosho, Katsuhiko: 20 articles (10/2012 - 05/2005)
8.	Sharma, Sherven: 19 articles (06/2008 - 12/2002)
9.	Shima, Kaori: 18 articles (06/2013 - 12/2008)
10.	Subbaramaiah, Kotha: 18 articles (05/2011 - 05/2002)

Related Diseases

1.	Pain (Aches) 10/01/2011 - "At 2 and 6 months follow-up (FU), the efficacy of combined treatment with these two dietary supplements was assessed using the visual analog pain scale (VAS) and the Lequesne index (LI) for joint function, as well as monitoring the use of anti-inflammatory drugs (nonsteroidal anti-inflammatory drugs and anti-cyclooxygenase-2). " 03/01/2001 - "Selective cyclooxygenase-2 (COX-2) inhibitors have provided relief for patients suffering from chronic pain and other inflammatory conditions and have reduced adverse gastrointestinal effects. " 01/01/2007 - "MK-0703 (a cyclooxygenase-2 inhibitor) in acute pain associated with dental surgery: a randomized, double-blind, placebo- and active comparator-controlled dose-ranging study." 08/01/2015 - "Genetic Variants in Cyclooxygenase-2 Contribute to Post-treatment Pain among Endodontic Patients." 03/01/2015 - "Human colonic SMCs were isolated and stretched in vitro to investigate whether mechanical stress upregulates expression of the pain mediator cyclooxygenase-2 (COX-2). "
2.	Neoplasms (Cancer) 07/01/2013 - "This novel regimen including a cyclooxygenase 2 inhibitor may be an effective regimen for metastatic inflammatory myofibroblastic tumors. " 01/01/2006 - "Multiple lines of evidence suggest that nonsteroidal anti-inflammatory drugs, especially those that specifically target cyclooxygenase-2 (COX-2), are effective in preventing certain cancers. " 10/01/2014 - "Immunohistochemical study of cyclooxygenase-2 in skin tumors." 08/25/2014 - "In this study, we show that miR-137 is under-expressed in GC and functions as a tumor suppressor through targeting Cyclooxygenase-2 (Cox-2), which subsequently suppresses the activation of PI3K/AKT signaling pathway both in vitro and in vivo. " 05/01/2014 - "Numerous studies suggest that cyclooxygenase-2 (COX-2) is overexpressed in cancer. "
3.	Inflammation 07/01/2015 - "We hypothesized that patients with VM would experience remission from symptoms after exercise training and that this effect may be mediated through the suppression of cyclooxygenase-2 (COX-2)-mediated inflammation. " 11/01/2010 - "This study examines whether a cyclooxygenase 2 (COX-2) pathway, often linked to inflammation, influences AID expression in activated B lymphocytes. " 11/01/2006 - "This study was undertaken to investigate the involvement of cyclooxygenase-2 (COX-2) in allergic nasal inflammation in actively sensitized rats. " 05/13/2005 - "In the present study, we show that treatment of the RAW 264.7 murine macrophage cell line with TSG-6 protein up-regulates the expression of inducible cyclooxygenase-2 (COX-2), a key enzyme in inflammation and immune responses. " 12/01/2004 - "The aim of this study was to evaluate the effect of cyclooxygenase-2 (COX-2) inhibition on muscle performance and mobility in hospitalized elderly patients with acute inflammation of infectious origin. "
4.	Osteoarthritis 01/01/2011 - "This study aims to investigate the relationship between the risk for the development of osteoarthritis and Cyclooxygenase-2 (COX 2) -765G>C gene polymorphism. " 01/01/2014 - "Our aims were to replicate some previously reported associations of single nucleotide polymorphisms (SNPs) in five genes (A2BP1, COG5, GDF5, HFE, ESR1) with hand osteoarthritis (OA), and to examine whether genes (BCAP29, DIO2, DUS4L, DVWA, HLA, PTGS2, PARD3B, TGFB1 and TRIB1) associated with OA at other joint sites were associated with hand OA among Finnish women. " 01/01/2012 - "To investigate the chondroprotective effect of cyclooxygenase 2 (COX-2) inhibition in experimental osteoarthritis (OA). " 01/01/2012 - "Lack of a chondroprotective effect of cyclooxygenase 2 inhibition in a surgically induced model of osteoarthritis in mice." 05/01/2009 - "Cyclooxygenase-2 inhibitor (COX-2) inhibitors were publicly subsidized in Australia for osteoarthritis. "
5.	Arthritis (Polyarthritis) 05/20/2003 - "The cost-effectiveness of cyclooxygenase-2 selective inhibitors in the management of chronic arthritis." 05/01/2006 - "A modified version was used daily in randomised control trials of patients with arthritis undergoing treatment with cyclooxygenase-2 specific inhibitors and non-steroidal anti-inflammatory drugs. " 08/01/2002 - "Effects of anti-arthritis preparations on gene expression and enzyme activity of cyclooxygenase-2 in cultured equine chondrocytes." 12/01/2000 - "The genetic ablation of cyclooxygenase 2 prevents the development of autoimmune arthritis." 03/16/2000 - "Selective inhibition of cyclooxygenase-2 with antisense oligodeoxynucleotide restricts induction of rat adjuvant-induced arthritis."

Related Drugs and Biologics

1.	celecoxib (Celebrex)
2.	rofecoxib (Vioxx)
3.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)
4.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
5.	Dinoprostone (PGE2)
6.	Messenger RNA (mRNA)
7.	nimesulide (Aulin)
8.	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)
9.	Cyclooxygenase 1
10.	N- (2- cyclohexyloxy- 4- nitrophenyl)methanesulfonamide

Related Therapies and Procedures

1.	Chemoprevention
2.	Drug Therapy (Chemotherapy)
3.	Heterologous Transplantation (Xenotransplantation)
4.	Adjuvant Chemotherapy
5.	Aftercare (After-Treatment)