Isomerases

A class of enzymes that catalyze geometric or structural changes within a molecule to form a single product. The reactions do not involve a net change in the concentrations of compounds other than the substrate and the product.(from Dorland, 28th ed) EC 5.

Networked: 29 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Furie, Bruce: 2 articles (03/2014 - 10/2012)
2.	Pompilio, Giulio: 1 article (06/2015)
3.	Nigro, Patrizia: 1 article (06/2015)
4.	Gowran, Aoife: 1 article (06/2015)
5.	Capogrossi, Maurizio Colognesi: 1 article (06/2015)
6.	Perrucci, Gianluca Lorenzo: 1 article (06/2015)
7.	Zanobini, Marco: 1 article (06/2015)
8.	Zheng, Wenhua: 1 article (02/2015)
9.	Rezaei, Hossein B: 1 article (02/2015)
10.	Piva, Terrence J: 1 article (02/2015)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 10/01/2008 - "These studies reveal that a CypA-mediated conformational change within the PRLr/Jak2 complex is required for PRL-induced transduction and function and indicate that the inhibition of prolyl isomerases may be a novel therapeutic strategy in the treatment of human breast cancer."
2.	Thrombosis (Thrombus) 03/28/2014 - "Regulation of thiol isomerase expression, analysis of the storage, and secretion of thiol isomerases and determination of the electron transfer pathway are key issues to understanding this newly discovered mechanism of regulation of the initiation of thrombus formation. " 03/28/2014 - "Thiol isomerases in thrombus formation." 02/01/2012 - "These data suggest that ERp57 is important for normal platelet function and opens up the possibility that the regulation of platelet function by a range of cell surface thiol isomerases may represent a broad paradigm for the regulation of haemostasis and thrombosis." 11/01/2011 - "Cell surface thiol isomerases might be therefore powerful targets to control hemostasis and thrombosis." 03/28/2014 - "The mechanism by which thiol isomerases participate in thrombus generation is being evaluated using trapping mutant forms to identify substrates of thiol isomerases that participate in the network pathways linking thiol isomerases, platelet receptor activation, and fibrin generation. "
3.	Neurodegenerative Diseases (Neurodegenerative Disease) 01/01/2006 - "Peptide bond isomerases are involved in important physiological processes that can be targeted in order to treat neurodegenerative disease, cancer, diseases of the immune system, allergies, and many others. " 01/01/2014 - "Possible therapeutic interventions for neurodegenerative disorders are (1) inhibition of proline-directed kinases, (2) activation of protein phosphatases such as PP2A, and (3) modulation of peptidyl-prolyl isomerases such as Pin1. "
4.	Starvation 06/01/2010 - "Periplasmic peptidyl-prolyl isomerases SurA and FkpA play an important role in the starvation-stress response (SSR) of Salmonella enterica serovar Typhimurium." 09/22/1998 - "However, in poor medium and, in particular, in the absence of amino acids, the growth of the double mutant strain was strongly decelerated, indicating that the prolyl isomerases become essential for growth under starvation conditions. "
5.	Shock 06/15/1993 - "Proline isomerases function during heat shock." 11/24/1994 - "We have previously shown that the principal structural protein of the human immunodeficiency virus HIV-1, the Gag polyprotein, binds the cyclophilin peptidyl-prolyl isomerases; cyclophilins catalyse a rate-limiting step in protein folding and protect cells from heat shock. "

Related Drugs and Biologics

1.	Proline (L-Proline)
2.	Cyclophilins (Cyclophilin)
3.	Protein Disulfide-Isomerases
4.	gag Gene Products (gag Protein)
5.	Enzymes
6.	Prostaglandin H2 (PGH(2))
7.	Cyclophilin A
8.	Xylitol
9.	Proteins (Proteins, Gene)
10.	Phosphotransferases (Kinase)