Fibromodulin

A small leucine-rich proteoglycan that contains 4 KERATAN SULFATE chains within the leucine repeat region. It interacts with COLLAGEN TYPE I and COLLAGEN TYPE II fibrils and may function to control the rate of EXTRACELLULAR MATRIX assembly. It also sequesters TRANSFORMING GROWTH FACTOR BETA in the extracellular matrix.

Also Known As:

Networked: 115 relevant articles (0 outcomes, 14 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Zheng, Zhong: 8 articles (01/2019 - 02/2011)
2.	Soo, Chia: 7 articles (01/2019 - 02/2011)
3.	Ting, Kang: 7 articles (01/2019 - 02/2011)
4.	Zhang, Xinli: 7 articles (01/2019 - 02/2011)
5.	Rabbani, Hodjattallah: 6 articles (07/2021 - 06/2005)
6.	Oldberg, Ake: 5 articles (02/2010 - 05/2002)
7.	Jiang, Wenlu: 4 articles (01/2019 - 01/2017)
8.	Li, Chenshuang: 4 articles (01/2019 - 01/2017)
9.	Kalamajski, Sebastian: 4 articles (01/2017 - 08/2007)
10.	Young, Marian F: 4 articles (02/2010 - 05/2002)

Related Diseases

1.	Wounds and Injuries (Trauma) 11/01/2016 - "In this study, using loss- and gain-of-function rodent fetal wound models, we identified that fibromodulin (Fm) is essential for fetal-type scarless wound healing. " 03/01/2011 - "Delayed wound closure in fibromodulin-deficient mice is associated with increased TGF-β3 signaling." 02/01/2011 - "Fractal dimension and lacunarity analysis effectively discriminated unwounded fibromodulin-null versus wild-type skin as well as healing fibromodulin-null versus wild-type wounds, whereas Fourier transform analysis failed to do so. " 04/01/2010 - "Immunohistochemical localization of fibromodulin during cellular wound healing showed that newly migrating periodontal cells toward the wound area were expressed strongly for fibromodulin at day 1 after wounding; thereafter, fibromodulin expression was noted stronger in newly migrating periodontal cells localized in the central part of the wound area than those around the wound area. " 05/01/2007 - "In vivo evaluation by histopathology and tensile strength demonstrated that Ad-Fibromodulin administration could ameliorate wound healing in incisional wounds. "
2.	Osteoarthritis 01/01/2019 - "Fibromodulin - A New Target of Osteoarthritis Management?" 10/01/2002 - "Fibromodulin-null murine knee joints display increased incidences of osteoarthritis and alterations in tissue biochemistry." 02/01/2010 - "We demonstrated for the first time a comprehensive study revealing the importance of the ECM in maintaining the mandibular condylar cartilage integrity and identified biglycan and fibromodulin as novel key players in regulating chondrogenesis and ECM turnover during temoporomandibular joint osteoarthritis pathology." 02/01/2010 - "Biglycan and fibromodulin have essential roles in regulating chondrogenesis and extracellular matrix turnover in temporomandibular joint osteoarthritis." 09/01/2005 - "The biglycan/fibromodulin double knock-out mouse constitutes a useful animal model to decipher the pathobiology of osteoarthritis in the TMJ."
3.	Diabetic Nephropathies (Diabetic Nephropathy) 03/01/2016 - "In this study, the therapeutic effects of recombinant adenoviral vectors expressing fibromodulin on TGF-β1 expression on diabetic nephropathy were assessed. " 04/01/2014 - "Comparative Proteomics Study of Streptozotocin-induced Diabetic Nephropathy in Rats Kidneys Transfected with Adenovirus-mediated Fibromodulin Gene." 01/01/2021 - "Identification of Lumican and Fibromodulin as Hub Genes Associated with Accumulation of Extracellular Matrix in Diabetic Nephropathy." 04/01/2014 - "Taken together, these results provide a valuable clue in exploring the mechanism underlying the therapeutic effects of fibromodulin in diabetic nephropathy suggesting that it can be a potential agent in the treatment of this disease." 03/01/2016 - "Recombinant fibromodulin has therapeutic effects on diabetic nephropathy by down-regulating transforming growth factor-β1 in streptozotocin-induced diabetic rat model."
4.	Cicatrix (Scar) 02/01/2011 - "To fully test the robustness of this scar analysis approach, a fibromodulin-null mouse model that heals with increased scar was also used. " 01/01/2018 - "Fibromodulin reduces scar size and increases scar tensile strength in normal and excessive-mechanical-loading porcine cutaneous wounds." 01/01/2017 - "Fibromodulin reduces scar formation in adult cutaneous wounds by eliciting a fetal-like phenotype." 05/01/2007 - "In conclusion, although the mechanism of scar formation in adult wounds remains incompletely understood, we found that fibromodulin overexpression improves wound healing in vivo, suggesting that fibromodulin may be a key mediator in reduced scarring." 05/01/2007 - "Effect of adenoviral mediated overexpression of fibromodulin on human dermal fibroblasts and scar formation in full-thickness incisional wounds."
5.	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 03/01/2011 - "to study the expression of fibromodulin at the gene level of B-cell chronic lymphocytic leukemia patients, in comparison to normal controls and to asses its role in the pathophysiology of CLL. " 03/01/2011 - "Study of fibromodulin gene expression in B-cell chronic lymphocytic leukemia." 01/01/2020 - "Within the hematopoietic compartment, fibromodulin (FMOD) is almost exclusively expressed in chronic lymphocytic leukemia (CLL) lymphocytes. " 06/01/2019 - "We have previously reported the aberrant expression of Fibromodulin (FMOD) in patients with chronic lymphocytic leukemia (CLL). " 06/01/2019 - "Anchored Fibromodulin as a Novel Target in Chronic Lymphocytic Leukemia: Diagnostic and Therapeutic Implications."

Related Drugs and Biologics

1.	Decorin
2.	Biglycan
3.	Collagen
4.	Lumican
5.	Proteoglycans (Proteoglycan)
6.	Small Leucine-Rich Proteoglycans
7.	Fibromodulin
8.	Proteins (Proteins, Gene)
9.	Messenger RNA (mRNA)
10.	Hyaluronic Acid (Hyaluronan)

Related Therapies and Procedures

1.	Therapeutics
2.	Surgical Instruments (Clip)
3.	Injections
4.	Immunotherapy