Osteoarthritis

A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.

Also Known As:

Networked: 15203 relevant articles (1030 outcomes, 2695 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Rheumatoid Arthritis
3.	Low Back Pain (Lumbago)
4.	Ankylosing Spondylitis
5.	Arthritis (Polyarthritis)

Experts

1.	Pelletier, Jean-Pierre: 58 articles (01/2016 - 01/2002)
2.	Martel-Pelletier, Johanne: 55 articles (01/2016 - 01/2002)
3.	Mobasheri, Ali: 29 articles (11/2015 - 12/2004)
4.	Kraus, Virginia B: 28 articles (12/2015 - 03/2002)
5.	Hochberg, Marc C: 27 articles (01/2016 - 01/2002)
6.	Kraus, V B: 26 articles (12/2015 - 03/2000)
7.	Goldring, Mary B: 26 articles (01/2015 - 10/2002)
8.	Kloppenburg, Margreet: 25 articles (09/2015 - 05/2005)
9.	Schnitzer, Thomas J: 24 articles (06/2015 - 01/2002)
10.	Lohmander, L S: 22 articles (11/2015 - 09/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Osteoarthritis:

1.	Hyaluronic Acid (Hyaluronan)IBA 01/01/2014 - "Although current evidence appears to favor PRP over hyaluronan for the treatment of osteoarthritis, the efficacy of PRP therapy remains unpredictable owing to the highly heterogeneous nature of reported studies and the variable composition of the PRP preparations. " 04/03/2009 - "The results of these studies demonstrate that enhanced chondrocyte survival and improved mitochondrial function under conditions of oxidative injury are probably important therapeutic mechanisms for the actions of hyaluronic acid in osteoarthritis." 12/01/2008 - "Clinically affected dogs had significantly greater degrees of pathologic findings, compared with dogs with surgically induced osteoarthritis (ie, those with CrCLt, GR, and MR stifle joints), and with respect to lameness scores, radiographic signs of osteoarthritis, pathologic findings on arthroscopy, and synovial fluid hyaluronan concentration. " 03/01/2012 - "However, evidence of efficacy of hyaluronic acid in ankle osteoarthritis is still lacking: several studies have been performed without a control group, or have shown similar results to those obtained with different therapeutic procedures. " 03/01/2015 - "Is intra-articular hyaluronic acid effective in treating osteoarthritis of the hip joint?"
2.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 12/01/2007 - "In particular, its proven efficacy, a fast onset of the analgesic action, its protective effect against the degradation of cartilage and a demonstrated low incidence of gastrointestinal adverse events compared with other NSAIDs make it a particularly valuable option in the symptomatic treatment of patients with joint osteoarthritis." 10/01/2001 - "Our findings indicate that NSAIDs may be effective in the etiopathogenesis of osteoarthrosis." 01/01/2006 - "To determine whether there is a difference in the relative efficacy of individual non-steroidal anti-inflammatory drugs (NSAIDs) when used in the management of osteoarthritis (OA) of the knee. " 01/01/2000 - "To determine whether there is a difference in the relative efficacy of individual non-steroidal anti-inflammatory drugs (NSAIDs) when used in the management of osteoarthritis (OA) of the knee. " 09/02/2011 - "Gastroprotective and safety effects of WIN-34B, a novel treatment for osteoarthritis, compared to NSAIDs."
3.	Diclofenac (SR 38)FDA LinkGeneric 11/20/2004 - "Acupuncture plus diclofenac is more effective than placebo acupuncture plus diclofenac for the symptomatic treatment of osteoarthritis of the knee." 01/01/2012 - "A comparison of the therapeutic efficacy of diclofenac in osteoarthritis: a systematic review of randomised controlled trials." 01/01/1991 - "The results of this 4-week study thus demonstrate that diclofenac dispersible is not only effective in treating osteoarthritis in the elderly but also has an acceptable tolerability profile in a patient population which is especially vulnerable to adverse effects induced by non-steroidal anti-inflammatory drugs." 09/01/1996 - "Effective treatment of osteoarthritis with a 150 mg prolonged-release of diclofenac sodium." 04/28/1986 - "The results of this review document that diclofenac is as effective as other nonsteroidal anti-inflammatory drugs in the treatment of osteoarthritis."
4.	Glucosamine (Dona)IBA 01/01/2011 - "Several clinical studies demonstrated that glucosamine sulfate (GS) is effective in controlling osteoarthritis (OA), showing a structure-modifying action. " 01/28/2008 - "This study explains the novel possibility of involvement of sulfated glucosamine in improving cellular antioxidant potential and thereby controlling oxidative damage that could be effective for its therapeutic potential in osteoarthritis. " 04/01/2007 - "Glucosamine sulfate (SGlc) has been known to be effective in controlling osteoarthritis (OA) symptoms in several clinical studies. " 01/01/2003 - "In short-term clinical trials, glucosamine provided effective symptomatic relief for patients with osteoarthritis of the knee. " 10/01/2001 - "Clinical studies indicate that glucosamine sulfate has been shown to be a safe and relatively effective treatment for osteoarthritis. "
5.	Acetaminophen (Paracetamol)FDA LinkGeneric 08/01/2004 - "To assess the best available evidence for efficacy of paracetamol (acetaminophen) in the treatment of osteoarthritis (OA). " 06/01/2002 - "Analgesic efficacy of sustained release paracetamol in patients with osteoarthritis of the knee." 12/01/2001 - "Acetaminophen is the safest OTC analgesic and is recommended as first-line treatment for osteoarthritis. " 02/01/2004 - "The interpretation of available evidence on the relative efficacy of nonsteroidal antiinflammatory drugs (NSAID) and acetaminophen in osteoarthritis (OA) has recently been debated. " 08/01/2015 - "While paracetamol can be tried, guidelines recommend non-steroidal anti-inflammatory drugs as first-line treatment for osteoarthritis. "
6.	Naproxen (Naprosyn)FDA LinkGeneric 02/01/1975 - "In a previous open clinical trial with d-2-(6'-methoxy-2'-naphthyl)-propionic acid (naproxen) in 32 outpatients with osteoarthrosis, very good to good results were achieved in 6 patients, satisfactory in 12, fair in 5, and unsatisfactory in 9 patients. " 01/01/1991 - "Improved cost-effectiveness ratio with a patient self-adjusted naproxen dosing regimen in osteoarthritis treatment." 11/01/2014 - "The aim of our study was to investigate the effects of naproxen, an antiinflammatory analgesic drug, on brain response to painful stimulation on the affected knee in chronic osteoarthritis (OA) using functional magnetic resonance imaging (fMRI) in a double-blind, placebo-controlled study. " 06/01/2014 - "Seventy-nine men and women (40-90 years old) diagnosed as having mild to moderate osteoarthritis (OA) consumed either 500 mg/day of the UP446 supplement or 440 mg/day of naproxen for 1 week in a double-blind randomized control trial. " 03/01/2014 - "In the context of part I of this paper in characterizing hand osteoarthritis (OA), we review clinical trials that have been conducted involving hand OA and naproxen. "
7.	celecoxib (Celebrex)FDA Link 11/01/1999 - "Celecoxib treatment led to significant improvement in the signs and symptoms of osteoarthritis as determined by all efficacy measures. " 09/15/2010 - "When compared to celecoxib, WIN-34B exhibited similar or better anti-nociceptive and anti-inflammatory activities in osteoarthritic animal models, which may become a potential novel treatment for osteoarthritis." 01/01/2014 - "Celecoxib is an effective treatment for osteoarthritis (OA). " 04/01/2008 - "This study shows that the quality of life improved in patients with osteoarthritis after 4 weeks of celecoxib treatment, in the physical as well psychological and social domains. " 10/07/2013 - "A prospective, randomized, double-blind, multicenter comparative study on the safety and efficacy of Celecoxib and GCSB-5, dried extracts of six herbs, for the treatment of osteoarthritis of knee joint."
8.	Ibuprofen (Motrin)FDA LinkGeneric 07/01/2014 - "Although anti-inflammatory doses of ibuprofen are very effective in treating the signs and symptoms of osteoarthritis (OA), they come with an increased risk for gastrointestinal damage which can limit their use and decrease patient adherence to therapy. " 01/01/1996 - "In conclusion, although both NSAID treatments improved the clinical condition of patients with painful osteoarthritis, statistically significant differences in favour of once-daily s-r ibuprofen (1600 mg) were demonstrated in terms of efficacy, indicating a potential therapeutic advantage for this formulation. " 11/01/2013 - "Investigate the safety and efficacy of a novel transdermal ibuprofen formulation (VALE®-ibuprofen) containing 10% ibuprofen, compared to a placebo in a randomized, double-blinded clinical trial, for clinical improvement in patients with moderate to severe painful osteoarthritis of the knee. " 01/01/2013 - " evidence from a single study of 174 people with hand osteoarthritis indicated that treatment with Arnica extract gel probably results in similar benefits as treatment with ibuprofen (non-steroidal anti-inflammatory drug) with a similar number of adverse events. " 07/13/1984 - "A review of 28 clinical trials involving ibuprofen for osteoarthritis shows sometimes conflicting results in efficacy, often because of inadequacies in study design or dosage. "
9.	hylanIBA 10/01/2009 - "Hylan G-F 20 significantly improved Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) physical function versus appropriate/conventional care or corticosteroid, it significantly improved loss of activity versus saline, and it had similar functional improvements compared with progressive knee exercises or nonsteroidal anti-inflammatory drugs. " 01/01/2006 - "Patients (n=1047; 1489 knees) were an average age of 65.3 years, 60% female, and 71% had radiologic osteoarthritis grade IV. Mean VAS scores significantly improved with hylan G-F 20 compared to baseline at all time points (P<.0001). " 01/01/2008 - "Hylan G-F 20 is well-tolerated and effective for up to 6 months in the treatment of symptomatic ankle osteoarthritis." 01/01/2008 - "A prospective multi-centre, open study of the safety and efficacy of hylan G-F 20 (Synvisc) in patients with symptomatic ankle (talo-crural) osteoarthritis." 08/01/2003 - "To study the efficacy of hylan G-F 20 in the treatment of osteoarthritis (OA) of the hip joint. "
10.	TramadolFDA LinkGeneric 05/01/2011 - "In this study, tramadol ER 300 mg was effective in the management of moderate to severe painful osteoarthritis of the hip or knee. " 03/01/2008 - "CR tramadol is effective for the management of painful osteoarthritis." 05/01/2011 - "Tramadol hydrochloride extended-release once-daily in the treatment of osteoarthritis of the knee and/or hip: a double-blind, randomized, dose-ranging trial." 01/01/2007 - "Once-daily tramadol extended release (ER) was evaluated for 12 weeks in a randomized, double-blind, placebo-controlled, parallel-group study in 1020 patients with osteoarthritis of the knee or hip. " 11/01/2004 - "This study compared the efficacy and tolerability of tramadol LP 200 mg, a new once-daily,sustained-release formulation, with those of placebo in patients with osteoarthritis of the hip or knee. "

Therapies and Procedures

1.	Arthroplasty 01/01/2011 - "Total shoulder arthroplasty seems to provide the best outcome for patients with osteoarthritis and inflammatory arthropathy. " 01/01/2004 - "This study demonstrates that the rare scenario of osteoarthritis coupled with a dysplastic glenoid can be treated successfully with shoulder arthroplasty." 04/01/2003 - "This study shows that the unlinked Souter-Strathclyde total elbow arthroplasty can be considered for patients with osteoarthritis and gives good symptomatic relief and improvement in function." 06/01/2015 - "Anatomic total shoulder arthroplasty (TSA) gives good outcome in the treatment of primary osteoarthritis, but it is not known whether this also applies to patients over 80 years old. " 06/01/2012 - "The leg length change in patients without iliofemoral osteoarthritis was significantly greater than that in patients with iliofemoral osteoarthritis, and the higher hip motion group had greater leg length change in total hip arthroplasty than the lower motion group. "
2.	Osteotomy 07/06/2011 - "Osteotomies are reported to be effective for the treatment of most cases of primary and traumatic moderate osteoarthritis of the ankle joint. " 03/01/1990 - "The best results were seen in knees with pre-operative grade I or grade II osteoarthritis and valgus deviation after osteotomy." 03/01/1993 - "Improvement in gait one year after surgery for knee osteoarthrosis: a comparison between high tibial osteotomy and prosthetic replacement in a prospective randomized study." 03/01/2015 - "The mean increase in grades was 0.31 (0 to 2) and 0.41 (0 to 2) in the maltracking and instability groups respectively (p = 0.2285) This self-centring tibial tubercle osteotomy provides good results at ten years' follow-up without inducing progressive osteoarthritis." 10/01/2014 - "High tibial osteotomy and unicondylar knee may produce good results in unilateral osteoarthritis of the knee. "
3.	Intra-Articular Injections 01/01/2011 - "Intra-articular injection is effective for osteoarthritis, but the best single injection strategy is not known, nor are there established predictors of response. " 01/01/2011 - "There is insufficient evidence to determine whether intra-articular injections may be effective for treatment of glenohumeral osteoarthritis. " 01/01/2002 - "In many cases intraarticular injections of hyaulonic acid were effective for sports related chondral lesion, because the chondral defect is recognized as an early stage of osteoarthritis. " 09/21/2011 - "Previous studies have indicated that five weekly intra-articular injections of hyaluronate were safe and effective in the treatment of ankle osteoarthritis. " 12/01/2014 - "As a treatment method of degenerative arthritis of knee, this study evaluated the clinical efficacy of the intra-articular injection of autologous bone marrow aspirates concentrate (BMAC) with adipose tissue. "
4.	Injections 01/01/2010 - "Although several randomized controlled trials have established the efficacy of this treatment modality, additional high quality randomized control studies with appropriate comparison are still required to clearly define the role of intra-articular HA injections in the treatment of osteoarthritis." 04/10/2004 - "In high quality studies, the pooled relative risk for improvement in symptoms of osteoarthritis of the knee at 16-24 weeks after intra-articular corticosteroid injections was 2.09 (95% confidence interval 1.2 to 3.7) and the number needed to treat was 4.4. " 11/01/1996 - "To show whether intra-articular steroid injections are effective in osteoarthritis; to determine factors that predict response; and to determine whether injection has a beneficial effect on muscle strength. " 04/01/2015 - "We have therefore continued the use of palpation-guided intra-articular knee injections in an effort to reduce costs as compared to other injection modalities with positive results in our osteoarthritis patients." 07/01/2013 - "Platelet-rich plasma (PRP) injections as an effective treatment for early osteoarthritis."
5.	Viscosupplementation 08/01/2008 - "Our findings show that AD is beneficial in osteoarthritis of the knee in patients with appropriate indications, viscosupplementation increases the efficacy of treatment, and that low- and high-molecular-weight HA preparations have similar efficacy." 11/01/2009 - "Viscosupplementation of the hip for symptomatic osteoarthritis appears to be safe and effective in more than 25 yr of use in Europe. " 09/01/2008 - "Likewise, viscosupplementation has proved to be efficacious in the management of osteoarthritis of the knee. " 09/01/2002 - "Viscosupplementation: a new treatment option for osteoarthritis." 01/01/2011 - "The objective of this review is to assess the efficacy of viscosupplementation treatment of ankle osteoarthritis in the current literature. "