Proteoglycans (Proteoglycan)

05/15/2008 - "Here, we showed that regulatory T cells (Tregs) play a role in the natural disease course of proteoglycan-induced arthritis (PGIA) and in disease remission by aBMT. "
11/01/1993 - "Effect of pregnancy on proteoglycan-induced progressive polyarthritis in BALB/c mice: remission of disease activity."
06/01/1986 - "In two patients with spontaneous remission of their arthritis a reduction in the proteoglycan content in the synovial fluid was also noted. "
05/15/2015 - "In this study, we aimed to examine whether DEC205(+) DC targeting of a single immunodominant peptide derived from human cartilage proteoglycan (PG) can promote immune tolerance in PG-induced arthritis (PGIA). "
01/01/2015 - "We used a proteoglycan-induced arthritis (PGIA) model in Balb/c mice to study AS in humans. "

08/01/1998 - "In each case, the total proteoglycan content of the tumor was significantly greater than that of the corresponding normal tissue. "
01/01/2015 - "These studies may lead to novel therapeutic strategies for cancers expressing Reg IV. Recently, one proteoglycan was confirmed to disrupt this signaling pathway to perform antitumor effect. "
12/01/1993 - "Using this clone, in the present study we isolated and characterized a membrane-intercalated proteoglycan that mediates interaction between the tumor cells and interstitial matrix. "
04/01/1989 - "In conclusion this study has reproduced in vitro a tumor-associated matrix with a proteoglycan composition similar to that observed in vivo and provides further support to the concept that production of a proteoglycan-rich extracellular environment is regulated by specific tumor-host cell interactions."
01/01/1984 - "Additional studies utilizing invasive and metastatic tumor variants including tumor cells that employ different mechanisms to invade are required to clarify the role of proteoglycans in tumor progression."

08/01/2013 - "Histopathological analysis showed significant reduction of tissue injury and inflammation and decreased proteoglycan loss. "
01/01/2014 - "Our previous studies demonstrated that salmon cartilage proteoglycan (PG) suppresses excess inflammation in different mouse inflammatory diseases. "
09/01/2010 - "In the current study, we examined the role of these proteoglycans in the breakdown of the chemokine gradient and resolution of corneal inflammation. "
01/01/2003 - "Total knee joints were isolated to study inflammation and cartilage destruction (loss of proteoglycans [PGs], chondrocyte death, matrix metalloproteinase [MMP]-mediated neoepitope [VDIPEN] expression, and erosion). "
07/01/1985 - "Recent studies have shown that joint inflammation can suppress chondrocyte proteoglycan synthesis and can even kill chondrocytes. "

01/01/2000 - "MALDI-TOF mass spectrometry provides an improved level of detail for extracellular matrix protein and proteoglycan structure and is useful in addressing issues surrounding the causes of degradation during osteoarthritis."
09/01/2015 - "In this study, we explore topographical changes in proteoglycan distribution from femoral condylar cartilage in early osteoarthritis, acquired from both the lateral and medial condyles of anterior cruciate ligament transected (ACLT) and contralateral (CNTRL) rabbit knee joints, at 4 weeks post operation. "
10/01/2011 - "This study investigated the effects of pulsed electromagnetic fields (PEMFs) on proteoglycan (PG) metabolism of human articular cartilage explants from patients with osteoarthritis (OA). "
01/01/2002 - "The aim of this study was to investigate the effects of Condrosulf on total proteoglycan synthesis and cell proliferation in human osteoarthritis and healthy juvenile bovine chondrocytes in vitro. "
11/01/1998 - "The study was performed to clarify the metabolic background of the variations in proteoglycan concentrations, relating to ageing and the spontaneous development of osteoarthrosis in guinea pigs. "

10/01/2015 - "Taken together, our results suggest that early Ad-OPG treatment has potent protective effects against cartilage destruction during rheumatoid arthritis progression, mainly by reducing proteoglycan loss and chondrocyte apoptosis. "
01/01/1988 - "This study details the macromolecular changes in cartilage involving proteoglycan molecules in an animal model of rheumatoid arthritis. "
07/01/2015 - "Rheumatoid arthritis: Manipulating the FLS 'proteoglycan switch' could offer a new approach to RA therapy."
05/20/2015 - "Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy."
12/01/2014 - "Anti–citrullinated protein antibody positivity correlates with cartilage damage and proteoglycan levels in patients with rheumatoid arthritis in the hand joints."