Surfactant Dysfunction

02/01/1997 - "We examined the effect of surfactant instillation on alveolo-capillary barrier function in an experimental model of surfactant dysfunction by measuring pulmonary clearance of 99mTc-DTPA. "
02/01/1997 - "Pulmonary clearance of 99mTc-DTPA in experimental surfactant dysfunction treated with surfactant instillation."
04/01/1997 - "This study has evaluated the click test, a biophysical test for surfactant function, which will be useful in rapidly and reliably identifying term neonates with surfactant dysfunction. "
01/01/2015 - "Multiple mutations of surfactant genes causing surfactant dysfunction have been described. "
08/01/2013 - "Even if the coupling between surfactant dysfunction and the underlying disease is not always well understood, using exogenous surfactants as replacement is usually a standard therapeutic option in respiratory distress. "

11/01/1999 - "To investigate the effects of large tidal volume ventilation (LTVV) and surfactant dysfunction induced with dioctyl sodium sulphoccinate (DOSS) on alveolocapillary permeability, and on the surface tension of lung tissue extract (LTE). "
09/01/1992 - "We measured the pulmonary clearance of inhaled 99mTc-DTPA and 99mTc-albumin in rabbits with surfactant dysfunction induced by dioctyl sodium sulphosuccinate and in rabbits with lung injury induced by oleic acid. "
04/01/1993 - "We measured the pulmonary clearance of inhaled 99mTc-diethylenetriamine penta-acetic acid (DTPA), 99mTc-sestamibi and 99mTc-dimethyliminodiacetic acid (HIDA) in normal rabbits, and rabbits with surfactant dysfunction induced by the detergent dioctyl sodium sulfosuccinate. "

08/01/1992 - "The findings support the hypothesis that increased clearance of 99mTc DTPA in smokers is related to surfactant dysfunction."
04/01/1993 - "We measured the pulmonary clearance of inhaled 99mTc-diethylenetriamine penta-acetic acid (DTPA), 99mTc-sestamibi and 99mTc-dimethyliminodiacetic acid (HIDA) in normal rabbits, and rabbits with surfactant dysfunction induced by the detergent dioctyl sodium sulfosuccinate. "

11/01/2008 - "However, rats given LC + combined acid and small gastric food particles versus LC had more severe surfactant dysfunction based on decreases in surface activity and alterations in large aggregate composition. "
04/01/2005 - "This study examines surfactant dysfunction in rats with inflammatory lung injury from intratracheal instillation of hydrochloric acid (ACID, pH 1.25), small nonacidified gastric particles (SNAP), or combined acid and small gastric particles (CASP). "
04/01/1993 - "We measured the pulmonary clearance of inhaled 99mTc-diethylenetriamine penta-acetic acid (DTPA), 99mTc-sestamibi and 99mTc-dimethyliminodiacetic acid (HIDA) in normal rabbits, and rabbits with surfactant dysfunction induced by the detergent dioctyl sodium sulfosuccinate. "

03/01/2023 - "Novel insights into congenital surfactant dysfunction disorders by in silico analysis of ABCA3 proteins."
01/01/2023 - "Surfactant dysfunction was identified in BIP and BP, and was only partially the result of protein exudation. "
12/15/2019 - ": We hypothesized that proteins and protein pathways in BAL fluid (BALF) would distinguish children with neuroendocrine cell hyperplasia of infancy (NEHI), surfactant dysfunction mutations, and other chILD diagnoses and control subjects.Methods"
02/01/1997 - "In animal models of asthma, surfactant dysfunction was demonstrated, which was possibly due to protein inhibition. "
03/01/1989 - "Protein leaks and surfactant dysfunction in the pathogenesis of respiratory distress syndrome."

04/01/1993 - "Pulmonary clearance of tracers with different lipid and water solubility in experimental surfactant dysfunction."
04/01/1993 - "Surfactant dysfunction affects the transfer of water soluble substances (99mTc-DTPA) but not of substances with high lipid solubility (99mTc-HIDA)."
12/01/2016 - "Among the few molecularly defined entities, mutations in the gene encoding the ATP-binding cassette (ABC), subfamily A, member 3 (ABCA3) lipid transporter represent the main cause of inherited surfactant dysfunction disorders, a subgroup of ILD. "
05/01/2008 - "Direct inhibition by TB lipids could worsen surfactant dysfunction caused by plasma proteins or other endogenous substances induced by inflammatory injury in the infected lungs. "
11/10/2005 - "We hypothesize that these surface-active mycobacterial cell wall lipids could interact with the pulmonary surfactant and result in lung surfactant dysfunction. "

01/01/2010 - "The most extensively studied mechanism of surfactant dysfunction is serum protein inhibition. "
01/16/1998 - "It is concluded that leakage of plasma proteins into the airway lumen was probably the main reason for the surfactant dysfunction, which may have contributed to the altered breathing pattern."
07/19/2000 - "Acute lung injury results in surfactant dysfunction due in part to inhibition by serum proteins. "
06/01/2013 - "Surfactant dysfunction in meconium aspiration syndrome (MAS) is caused by meconium components, by plasma proteins leaking through the injured alveolocapillary membrane and by substances originated in meconium-induced inflammation. "
01/01/1990 - "It has been previously demonstrated that surfactant dysfunction occurs when plasma protein inhibitors leak into the alveolar space during the induction of the lung injury and edema formation. "

02/01/1997 - "Surfactant dysfunction was induced by administration of a synthetic detergent in aerosol form. "
03/01/1996 - "The combined effect of large tidal volume ventilation (LTVV) and detergent-induced surfactant dysfunction on the clearance kinetics of technetium-99m-labelled diethylene triamine pentaacetate was investigated. "
04/01/1993 - "We measured the pulmonary clearance of inhaled 99mTc-diethylenetriamine penta-acetic acid (DTPA), 99mTc-sestamibi and 99mTc-dimethyliminodiacetic acid (HIDA) in normal rabbits, and rabbits with surfactant dysfunction induced by the detergent dioctyl sodium sulfosuccinate. "

04/01/1983 - "Surfactant dysfunction in diabetic offspring: inhibitors and fatty acid lecithin content."
07/01/1998 - "These results indicate that surfactant dysfunction in acute respiratory distress syndrome (ARDS) could be increased in severity by interactions between some inhibitory substances, but that supplementation with exogenous CLSE would be effective in reversing inactivation by the mixtures of blood proteins, membrane lipids, and fatty acids studied."

12/01/2012 - "Low SP-B values increased with calfactant administration, but the relationship of this response to SP-B levels suggests that degradation is a contributing mechanism for SP-B deficiency and surfactant dysfunction. "
01/01/2014 - "Synthetic surfactants and Infasurf improved lung function further in lavage- than in chemical-induced respiratory failure, with the difference probably due to greater capillary-alveolar protein leakage and surfactant dysfunction after HCl instillation than following lung lavage. "

10/01/2022 - "Gene Therapeutics for Surfactant Dysfunction Disorders: Targeting the Alveolar Type 2 Epithelial Cell."
11/22/2023 - "In conclusion, this comprehensive review offers valuable insights into the pathogenic mechanisms of genetic disorders of surfactant dysfunction, genetic fundamentals, available and emerging therapeutic options, and underscores the need for further research to develop personalized therapies for affected infants and children."
11/22/2023 - "Towards personalized therapies for genetic disorders of surfactant dysfunction."
10/01/2022 - "This review focuses on the pathophysiology associated with these genetic disorders of surfactant dysfunction, and also provides an overview of the current state of gene-based therapeutics designed to target and transduce the AT2 cells."
01/01/2021 - "Successes and challenges in developing gene therapies for genetic disorders of surfactant dysfunction include viral vector design and tropism for target cell types. "

09/01/2005 - "Despite improved outcome, endothelial cell injury and surfactant dysfunction remain a significant problem after lung transplantation. "
03/31/2018 - "For surfactant dysfunction disorders in infancy and early childhood, lung transplantation was reported to be as successful as in adult patients. "
03/01/2000 - "Ischaemia/reperfusion (I/R) injury, a major problem in clinical lung transplantation, is associated with surfactant dysfunction. "

01/01/2017 - "Various pathophysiological conditions such as surfactant dysfunction, mechanical ventilation, inflammation, pathogen products, environmental exposures, and gastric acid aspiration stress lung cells, and the compromise of plasma membranes occurs as a result. "
10/01/2003 - "In summary, despite the use of INO, synergetic effects of long-term hyperoxia, mechanical ventilation and inflammation following CPB may exacerbate pulmonary mechanics and result in surfactant dysfunction."
04/01/2003 - "Evidence suggests that preterm neonates with bronchopulmonary dysplasia and prolonged mechanical ventilation also experience surfactant dysfunction; however, exogenous surfactant therapy beyond the first week of life has not been well studied. "

11/01/1986 - "Vagotomy results in alveolar pulmonary edema, and surfactant dysfunction despite normal surfactant pool sizes and respiratory failure. "

07/01/2004 - "Pulmonary preservation for transplantation is associated with ischemia reperfusion injury resulting in endothelial cell and surfactant dysfunction. "