Interstitial Lung Diseases (Interstitial Lung Disease)

A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.

Also Known As:

Networked: 4416 relevant articles (205 outcomes, 333 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Systemic Scleroderma (Systemic Sclerosis)
2.	Dermatomyositis (Dermatopolymyositis)
3.	Polymyositis
4.	Infection
5.	Myositis (Idiopathic Inflammatory Myopathies)

Experts

1.	Mukae, Hiroshi: 24 articles (05/2015 - 02/2002)
2.	Kohno, Shigeru: 22 articles (05/2015 - 02/2002)
3.	Kuwana, Masataka: 20 articles (05/2015 - 06/2004)
4.	Sakamoto, Noriho: 19 articles (05/2015 - 02/2002)
5.	Mimori, Tsuneyo: 19 articles (01/2015 - 05/2005)
6.	Colby, Thomas V: 18 articles (12/2015 - 03/2002)
7.	Suda, Takafumi: 17 articles (09/2015 - 07/2003)
8.	Wells, Athol U: 16 articles (10/2015 - 03/2002)
9.	Brown, Kevin K: 16 articles (10/2015 - 05/2004)
10.	Kakugawa, Tomoyuki: 16 articles (05/2015 - 02/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Interstitial Lung Diseases:

1.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 06/01/2005 - "Additional intravenous Cyclophosphamide (IVCY) was initiated on the 6th hospital day, and interstitial pneumonia was markedly improved. " 11/01/2003 - "Cyclophosphamide may soon be proven effective against interstitial lung disease." 12/01/2006 - "Cyclophosphamide (CYC) seems to be beneficial in interstitial lung disease associated with SSc. " 01/01/1996 - "Four months later, he developed severe interstitial pneumonitis, and his symptoms were not improved by high-dose steroid pulse and cyclophosphamide pulse treatment. " 03/01/2009 - "Oral cyclophosphamide therapy is effective for non specific interstitial pneumonitis of scleroderma in a randomized control trial. "
2.	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/01/2006 - "Treatment with high-dose corticosteroid and cyclosporin A steadily improved his interstitial pneumonia. " 08/01/1991 - "Cyclosporin A may be effective in the treatment of interstitial lung disease of unknown aetiology. " 06/01/2005 - "Our case suggested that combination therapy with steroid, Cyclosporin-A, and IVCY is useful for the treatment of progressive interstitial pneumonia with DM." 11/01/2005 - "The aim of this study was to evaluate the efficacy of cyclosporin A (CsA) in patients with interstitial pneumonia (IP). " 12/01/2003 - "Soon after starting oral cyclosporin A (CyA) the skin lesions healed completely and the interstitial pneumonia promptly improved in parallel with a decrease in serum KL-6. "
3.	Prednisolone (Predate)FDA LinkGeneric 10/01/2003 - "In the first patient, oral prednisolone (PSL) treatment (20 mg day) improved the interstitial pneumonia, but PSL has now been tapered to 17.5 mg day. " 05/01/1997 - "Oral prednisolone treatment was started and the retinopathy was improved, but was complicated by acute interstitial pneumonia. " 06/01/1989 - "[An experimental study on prednisolone-induced interstitial pneumonia caused by Pneumocystis carinii]." 04/01/2010 - "We prospectively reviewed 43 patients who received CsA and prednisolone for fibrosing interstitial pneumonia over 180 days at our hospital between April 2004 and October 2008. " 02/01/2008 - "A 64-year-old woman had been treated with prednisolone (PSL) for interstitial pneumonia (IP) of unknown origin since 1988. "
4.	Tacrolimus (Prograf)FDA LinkGeneric 12/01/2005 - "Is tacrolimus effective for treating antisynthetase-associated interstitial lung disease?" 01/01/2013 - "Our experience in this case suggests that treatment with tacrolimus might be useful for treating refractory LD-CTD even when histopathologically chronic fibrotic interstitial pneumonia is evident." 08/01/2005 - "Treatment of antisynthetase-associated interstitial lung disease with tacrolimus." 02/01/2004 - "Eight patients (50%) in Group I required discontinuation of tacrolimus, seven because of biopsy-proven tacrolimus nephrotoxicity and one secondarily to interstitial pneumonitis. " 01/01/2015 - "Tacrolimus in idiopathic inflammatory myopathy-associated interstitial lung disease: defining roles and responders."
5.	MethylprednisoloneFDA LinkGeneric 09/01/1995 - "However, this induced severe interstitial pneumonitis, which was not cured by discontinuation of the drug, but disappeared completely with six episodes of methylprednisolone pulse therapy. " 01/01/2015 - "A case of methylprednisolone treatment for interstitial pneumonia induced by gefitinibin." 01/01/2014 - "Pulse therapy with methylprednisolone and cyclophophamide could transiently improve myalgia and so on, but she died of rapidly progressive interstitial lung disease. " 11/01/2013 - "However, he developed interstitial pneumonia, and thus received pulse corticosteroid therapy with methylprednisolone. " 10/01/2008 - "He was treated with methylprednisolone under a diagnosis of interstitial pneumonia. "
6.	SteroidsIBA 01/01/1989 - "In seven patients there was symptomatic improvement with steroid therapy, but three patients who were not treated with steroids died as a result of interstitial pneumonia. " 06/01/1988 - "One patient with chronic infiltrates showed a lymphocytic interstitial pneumonia, which responded well to steroids. " 05/01/2012 - "Even when severe interstitial lung disease developed, withdrawal of the drug and short-term use of high-dose steroids resulted in rapid recovery. " 01/01/2008 - "She was diagnosed with interstitial pneumonia and treated with steroids. " 09/01/2006 - "A lung biopsy was consistent with interstitial pneumonitis and following withdrawal of the drug and treatment with steroids her symptoms resolved. "
7.	Adrenal Cortex Hormones (Corticosteroids)IBA 03/01/1997 - "Corticosteroids and immunosuppressive drugs have been used to treat lymphocytic interstitial pneumonia, and they were effective in this case." 10/19/2002 - "Although early observations showed some benefit of corticosteroids, it is now well established that these studies in fact included a proportion of other corticosteroid-sensitive diseases, such as non-specific interstitial pneumonia. " 07/01/2015 - "Few data are available regarding vertebral fracture risk in patients treated with corticosteroids including patients with interstitial lung disease (ILD). " 06/01/2015 - "The presence of an interstitial lung disease is a major prognostic factor and an indication for more intensive treatment, principally with systemic corticosteroids with or without immunosuppressive drugs. " 11/01/2014 - "Predictors of mortality in patients with interstitial lung disease treated with corticosteroids: results from a cohort study."
8.	Methotrexate (Mexate)FDA LinkGeneric 06/01/2015 - "Methotrexate (MTX), as the most important disease modifying drug for treatment of RA is not associated with the appearance or progression of interstitial lung disease in RA. " 06/01/2014 - "This report highlights the necessity for pediatricians to be continuously vigilant for interstitial pneumonitis in children receiving methotrexate who develop new unexplained pulmonary symptoms. " 04/01/2014 - "Methotrexate has also been implicated as a causative agent in interstitial lung disease. " 11/01/2013 - "The patient had no pre-existing lung pathology, while his previous exposure to methotrexate was minimal and was not temporally associated with the induction of interstitial lung disease." 06/01/2006 - "Interstitial pneumonitis is a well documented, rare complication of methotrexate (MTX). "
9.	gefitinib (Iressa)FDA Link 07/01/2010 - "Gefitinib is highly effective for patients with advanced NSCLC with EGFR mutation even if their performance status is poor, although one should always pay careful attention to fatal interstitial lung disease." 04/01/2013 - "Gefitinib therapy was discontinued and treatment with high-dose steroid therapy improved the interstitial lung disease. " 03/01/2006 - "The authors report a case of interstitial lung disease (ILD) induced by gefitinib, which improved promptly following cessation of the administration of the agent. " 03/01/2014 - "Pulmonary toxicity such as interstitial lung disease associated with gefitinib is uncommon with an estimated all time incidence around 1% worldwide. " 01/01/2014 - "This fact suggested that the cases of acute interstitial pneumonia were included in the clinical trial before the approval of gefitinib. "
10.	Carbon MonoxideIBA 12/01/2015 - "Different lymphoid histological lesions can co-exist and form a new entity called GLILD (granulomatous lymphocytic interstitial lung disease), which is associated with a poor prognosis. " 07/01/2014 - "Interstitial lung disease usually associates restrictive functional defect, impairment of carbon monoxide diffusion and interstitial lung disease on CT scan. " 01/01/2014 - "A non-contrastive high-resolution CT scan showed bilateral interstitial lung disease with an associated reduction in carbon monoxide diffusing capacity. " 11/01/2011 - "Most literature suggests that PIG is one of the few pediatric interstitial lung diseases that has a favorable prognosis with rare mortality in the absence of co-morbidities. " 09/01/2011 - "Pulmonary function tests revealed a moderate restrictive pattern with impaired diffusion of carbon monoxide and a bronchiolocentric interstitial pneumonia was found at lung biopsy. "

Therapies and Procedures

1.	Transplantation (Transplant Recipients) 09/18/1982 - "Six patients are alive and well in complete clinical, cytogenetic, and haematological remission, 1-3 years after transplantation, despite complications in three patients (one had interstitial pneumonitis, one had mild veno-occlusive disease of the liver, and one had severe GvHD)." 06/01/1991 - "Variables significantly associated with both increased survival and relapse-free survival included transplantation in first remission, younger patient age, and not developing interstitial pneumonia. " 04/01/1982 - "Passive immunization with a CMV immune plasma has been found to be effective for the prevention of interstitial pneumonia after marrow transplantation. " 04/01/2000 - "After transplantation, the patient had grade II acute GVHD and cytomegalovirus(CMV) interstitial pneumonia; he was cured. " 01/01/2005 - "This study suggests that HHV-7 may play an important role in causing interstitial pneumonia in patients who are not transplant recipients."
2.	Transplants (Transplant) 07/01/1988 - "Six patients died in complete remission from cytomegalovirus (CMV) interstitial pneumonitis and three remain alive in complete remission 2, 3 and 13 months after transplant. " 01/01/2009 - "It is important to differentiate IPF from other fibrotic interstitial lung diseases and to refer to a specialist centre, especially in the case of patients who could be eligible for a lung transplant or for participation in trials with new drugs." 02/01/1994 - "Common odds ratios for the trials reporting cytomegalovirus interstitial pneumonia, cytomegalovirus death, overall death and graft loss ranged from 0.47 to 0.69. " 05/01/1993 - "To study the association between cytomegalovirus (CMV) excretion and interstitial pneumonitis in allogeneic bone marrow transplant (BMT) recipients, with reference to donor and recipient CMV antibody response. " 09/01/2015 - "In the evaluation of patients with interstitial lung diseases (ILD), treatment decisions made by clinicians, including referral for lung transplant, are based on disease severity assessment. "
3.	Drug Therapy (Chemotherapy) 01/01/2014 - "This descriptive study used the Japanese spontaneous reporting data to investigate the time taken (TTILD) to development of interstitial lung disease (ILD) after initiation of chemotherapy and the death rates attributed in part to post-chemotherapy ILD (i.e., DR) for anticancer drugs. " 11/01/2014 - "Interstitial pneumonia caused by the chemotherapy occurred and the volume occupied, it was continued treatment is difficult. " 06/01/2014 - "In contrast, some forms of interstitial lung disease can respond well to treatment with immunosuppressive drug therapies. " 04/01/2014 - "The incidence of interstitial lung disease, which is a concern during chemotherapy, was 2.6%. " 01/01/2014 - "A descriptive analysis of post-chemotherapy development of interstitial lung disease using spontaneous reporting data in Japan."
4.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 06/01/1979 - "New attempts are being made to improve the results : (1) better cytoreductive therapy preceding transplanation, (2) bone marrow transplantation during remission of the disease, (3) prevention of interstitial pneumonitis by modifications of the TBI technique." 01/01/2006 - "This study evaluated patients for the influence of the dose rate and lung dose of fractionated total body irradiation (TBI) in preparation for allogeneic bone marrow transplantation (BMT) on the subsequent development of interstitial pneumonitis (IP). " 04/01/2004 - "The aim of this study is to evaluate the incidence of interstitial pneumonitis following fractionated total body irradiation conditioning for bone marrow transplantation with varying lung doses due to shielding technique and different dose-rates. " 12/01/1986 - "Interstitial pneumonitis in allogeneic bone marrow transplantation: a report from the Japanese BMT Study Group." 06/01/1985 - "In an attempt to reduce the incidence of lethal cytomegalovirus (CMV) interstitial pneumonitis after allogenic bone marrow transplantation 49 patients were randomized in a multicenter controlled study to receive either CMV-hyperimmune globulin or a control immune globulin with low anticytomegalovirus titer. "
5.	Aftercare (After-Treatment) 10/01/2003 - "During the average post-treatment follow-up period of 31.0 days (range 3 to 76 days), the opacities quickly improved after treatment in 6 patients; however, in 2 patients with pre-existing interstitial pneumonitis the opacities were refractory. " 09/01/2007 - "The scheduled number of cycles could be completed in all but one patient who developed interstitial pneumonia 2 days after treatment. " 03/01/2006 - "Thirteen cases with nonspecific interstitial pneumonia (NSIP) were evaluated before and after treatment. " 10/01/2004 - "Resolution of lymphocytic interstitial pneumonitis in an HIV infected adult after treatment with HAART." 06/01/1991 - "After treatment, one patient developed bacterial meningitis, and two developed MTX-induced interstitial pneumonitis, which was cured by steroid therapy. "