Abstract | BACKGROUND: METHODS: In 12 domestic pigs, lungs were flush preserved with either low- potassium dextran (n = 6) or low- potassium dextran supplemented by 5 mmol glutathione (n = 6). Left single lung transplantation was performed after 24-hour storage in low- potassium dextran at 8 degrees C. After 15 minutes of reperfusion the right main bronchus and pulmonary artery were crossclamped. Hemodynamic and respiratory measures were recorded in 30-minute intervals for a total observation period of 7 hours. Bronchoalveolar lavage fluid was obtained from the native lung and 2 hours after reperfusion from the graft. Bronchoalveolar lavage fluid and surfactant composition, and surfactant function analyses were performed. Neutrophil sequestration was assessed by myeloperoxidase activity assay. Tissue water content was calculated from wet/dry weight ratios at the end of the experiment. RESULTS: CONCLUSION:
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Authors | Sebastian-P Sommer, Bernhard Gohrbandt, Stefan Fischer, Jens M Hohlfeld, Gregor Warnecke, Murat Avsar, Martin Strüber |
Journal | The Journal of thoracic and cardiovascular surgery
(J Thorac Cardiovasc Surg)
Vol. 130
Issue 3
Pg. 864-9
(Sep 2005)
ISSN: 0022-5223 [Print] United States |
PMID | 16153941
(Publication Type: Journal Article)
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Chemical References |
- Dextrans
- Organ Preservation Solutions
- Pulmonary Surfactants
- Peroxidase
- Glutathione
- Potassium
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Topics |
- Animals
- Blood Pressure
- Body Water
(metabolism)
- Cardiac Output
- Dextrans
- Female
- Glutathione
(pharmacology)
- Lung
(metabolism)
- Lung Transplantation
- Organ Preservation
- Organ Preservation Solutions
(chemistry)
- Peroxidase
(analysis)
- Potassium
- Pulmonary Artery
(metabolism)
- Pulmonary Circulation
- Pulmonary Surfactants
(chemistry)
- Reperfusion Injury
(prevention & control)
- Swine
- Vascular Resistance
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