Lung Injury

Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.

Also Known As:

Networked: 8956 relevant articles (663 outcomes, 1166 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Inflammation
2.	Ischemia
3.	Hyperoxia
4.	Pancreatitis
5.	Sepsis (Septicemia)

Experts

1.	Matthay, Michael A: 49 articles (08/2015 - 01/2002)
2.	Garcia, Joe G N: 42 articles (12/2015 - 11/2003)
3.	Deitch, Edwin A: 36 articles (12/2014 - 06/2002)
4.	Schultz, Marcus J: 33 articles (12/2015 - 10/2006)
5.	Cuzzocrea, Salvatore: 32 articles (09/2015 - 01/2002)
6.	Choi, Augustine M K: 29 articles (11/2014 - 01/2002)
7.	Mazzon, Emanuela: 27 articles (10/2011 - 01/2002)
8.	Lu, Qi: 26 articles (12/2011 - 06/2002)
9.	Slutsky, Arthur S: 25 articles (01/2016 - 06/2002)
10.	Ryter, Stefan W: 25 articles (10/2013 - 05/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Lung Injury:

1.	Bleomycin (Blenoxane)FDA LinkGeneric 10/01/2012 - "We have observed significant protective effects of Tβ4 on bleomycin-induced lung damage, the main outcomes being the halting of the inflammatory process and a substantial reduction of histological evidence of lung injury." 07/01/2011 - "In conclusion, targeting CCL3/MIP-1α by treatment with evasin-1 is beneficial in the context of bleomycin-induced lung injury, even when treatment is started after the fibrogenic insult. " 05/01/2005 - "The aim of our study was to evaluate the therapeutic efficacy of in vivo inhibition of PARP in an experimental model of lung injury caused by bleomycin administration. " 12/01/2009 - "To investigate the contribution of mobilized autologous bone marrow-derived cells (BMDC) to lung repair after lung injury induced by bleomycin, and the mechanisms of any protective effects conferred by BMDC. " 08/01/2005 - "We sought to determine whether an intact bone marrow is essential to lung repair following bleomycin-induced lung injury in mice, and the mechanisms of any protective effects conferred by bone marrow-derived mesenchymal stem cell (BMDMSC) transfer. "
2.	OxygenIBA 01/01/2008 - "Strategies in ventilation and in exposure to the oxygen that minimise lung injury improved the prognosis of the extremely low weight newborns. " 05/01/1993 - "Arterial oxygen tension and pulmonary compliance deteriorated abruptly after lung injury in all cats, and improved significantly (p < .001, two-way analysis of variance) 15 mins after perfluorochemical liquid lavage. " 03/01/1998 - "Intraperitoneal administration of MR1, either before or after oxygen exposure, was remarkably effective in reducing and in many cases preventing lung injury. " 05/01/2013 - "ADORA2A is protective against lung injury after LPS and oxygen. " 11/01/2012 - "The Arg-Gln and DHA, with protective effects on hyperoxic lung injury in neonatal mice, are promising nutritional adjuncts that may prevent lung damage owing to oxygen toxicity in infants."
3.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/01/2006 - "In the event of a pandemic with a highly virulent virus, intervention directed at TNF-alpha should be given consideration, as this may be most likely to provide protection against severe lung injury at the lowest cost to viral clearance." 01/01/2009 - "Treatment of animals with a PPS aerosol significantly increased the phospholipid content in the BALF, improved lung function, reduced pulmonary oedema, decreased total protein and TNF-alpha concentrations in BALF, ameliorated lung injury and improved animal survival. " 12/01/2000 - "The relationship between TNF-alpha, gut toxicity, and lung injury was examined further by direct cytokine blockade in vivo; systemic neutralization of TNF-alpha resulted in a significant reduction in gut histopathology, BAL fluid LPS levels, and pulmonary dysfunction compared with control-treated animals. " 04/01/2012 - "Studies have shown that tumor necrosis factor-α (TNF-α) blockers have beneficial effects on lung injury. " 05/01/2008 - "This study was performed to determine whether the lectin-like domain of tumor necrosis factor-alpha (designated TIP) can improve fluid balance in experimental lung injury by affecting alveolocapillary permeability and/or fluid clearance. "
4.	CytokinesIBA 07/01/2014 - "In a murine model of TRALI, C1-inhibitor attenuated pulmonary levels of C3a associated with improved lung injury scores, but with persistent high levels of inflammatory cytokines." 06/01/2006 - "Intermittent ventilation has protective effects on the lung injury during CPB by decreasing granulocyte adhesion and the level of lung cytokines, alleviating the lung inflammatory reaction and endothelial cell injury." 01/01/2007 - "ARF may affect the lung via increased renal production or impaired clearance of mediators of lung injury, such as proinflammatory cytokines. " 12/15/2015 - "Initial studies of wild-type mice subjected to single-dose thoracic radiation (10 Gy) confirmed a significant increase in lung GADD45a expression within 24 h and persistent at 6 wk. Mice deficient in GADD45a (GADD45a(-/-)) demonstrated increased susceptibility to radiation-induced lung injury (RILI, 10 Gy) evidenced by increased bronchoalveolar lavage (BAL) fluid total cell counts, protein and albumin levels, and levels of inflammatory cytokines compared with RILI-challenged wild-type animals at 2 and 4 wk. Furthermore, GADD45a(-/-) mice had decreased total and phosphorylated lung Akt levels both at baseline and 6 wk after RILI challenge relative to wild-type mice while increased RILI susceptibility was observed in both Akt(+/-) mice and mice treated with an Akt inhibitor beginning 1 wk prior to irradiation. " 06/01/2015 - "The aim of the present study was to investigate the changes of various cytokines that may be involved in ablative radiation-induced lung injury in vitro and in vivo. "
5.	Peroxidase (Myeloperoxidase)IBA 04/01/2015 - "Markers of lung injury including permeability index, myeloperoxidase content, and bronchoalveolar lavage inflammatory cell counts were all reduced with toll-like receptor-4 knockdown. " 05/01/2014 - "Furthermore, compared with MSCs treated alone, Del1-MSC-treated mice also exhibited low lung injury scores, high protein concentrations and myeloperoxidase activity. " 02/01/2014 - "Lung injury was assessed by the histopathological changes, arterial blood gas, wet/dry (w/d) weight ratio and myeloperoxidase (MPO) activity of the lung. " 01/01/2014 - "Lung injury was evaluated via histology and lung neutrophil infiltration was evaluated by myeloperoxidase (MPO) staining. " 06/01/2012 - "Lung injury was assessed by wet/dry ratio, myeloperoxidase (MPO) activity, and bronchoalveolar lavage (BAL) neutrophil counts. "
6.	Oleic Acid (Oleate)IBA 07/01/2008 - "Compared with CMV, HFOV significantly improved the deteriorated oxygenation during the late phase (2-4 h) of oleic acid-induced lung injury without any deterioration effects on pulmonary or systemic hemodynamics. " 08/01/1999 - "Vaporization is a new application technique for perfluorocarbon that significantly improved oxygenation and pulmonary function in oleic acid-induced lung injury." 07/01/2008 - "These findings suggest that HFOV could contribute to decreased lung lymph filtration in pulmonary microcirculation and improved oxygenation following oleic acid-induced lung injury in sheep." 02/01/2004 - "Treatment of oleic acid-induced lung injury with PFH vapor improved oxygenation and mechanical lung function over a extended time period allowing a reduction in the invasiveness of ventilation." 01/01/1998 - "The delayed onset of symptoms suggested that the lung injury was due to the systemic circulation of oleate to the lungs rather than to direct aspiration. "
7.	ParaquatIBA 01/01/2008 - "Anti-TGF-beta1 antibody: an effective treatment for lung injury caused by paraquat in the future." 06/01/2014 - "[The efficacy of traditional Chinese medicin in animal model of lung injury induced by paraquat: a meta-analysis]." 06/01/2009 - "The purpose of this study was to report the long-term evolution of lung lesions in eight survivors with significant paraquat-induced lung injuries who could be followed-up for longer than 6 months. " 10/12/2004 - "The aim of this study was to evaluate the time course of in vivo and in vitro respiratory mechanics and examine whether these parameters could reflect the temporal changes in lung parenchyma remodelling in paraquat (PQ)-induced lung injury. " 09/01/1992 - "The purpose of this study was to establish a chronic model of paraquat-induced lung injury. "
8.	Antigen-Antibody Complex (Immune Complex)IBA 03/15/1992 - "Although anti-CD11b was not effective under the same experimental conditions, intratracheal administration of this antibody conveyed protection against immune complex-induced lung injury, suggesting that both CD11b and CD18 are required for the full expression of injury. " 10/01/1979 - "These studies emphasize the potential importance of immune complexes in lung injury and point out the variety of mechanisms involved in both the localization process and the injury process." 10/01/2014 - "However, the functions of these lipid mediators in immune complex-induced lung injury remain unknown. " 12/01/2009 - "We propose that lung injury in response to immune complex deposition is dependent on Rac2 in alveolar macrophages and neutrophils." 01/01/2000 - "These results suggest that anti-CK18 antibody and its immune complex may have played a role in the process of lung injury in IPF."
9.	Immunoglobulin G (IgG)IBA 06/15/2012 - "To do so, Escherichia coli was intratracheally instilled into C57BL/6 mice in the presence of neutralizing anti-LIF IgG or control IgG. Anti-LIF completely eliminated lung LIF detection and markedly exacerbated lung injury compared with control mice as evidenced by airspace albumin content, lung liquid accumulation, and histological analysis. " 07/01/2015 - "Mice were divided into 3 experimental groups to study the role of EphA2 signaling in the lipopolysaccharide (LPS)-induced lung injury model i.e., IgG+phosphate-buffered saline (PBS) group (IgG instillation before PBS exposure), IgG+LPS group (IgG instillation before LPS exposure) and EphA2 monoclonal antibody (mAb)+LPS group (EphA2 mAb pretreatment before LPS exposure). " 03/01/2000 - "The T/P ratio and BAL neutrophil counts were conspicuously decreased by pretreatment with anti-IL-8 Ab, but not with control IgG. On a histopathological study, lung injury and leukocyte infiltration were attenuated by the pretreatment with anti-IL-8 Ab. " 06/01/2008 - "aeruginosa-induced lung injury or rate of survival compared to pretreatment with control immunoglobulin G. " 07/01/2006 - "We further show that activation of STAT3 was inhibited by SOCS3 overexpression as well as by anti-IL-6 treatment during IgG IC-induced lung injury, as determined by EMSA. "
10.	SmokeIBA 05/01/2000 - "The delayed pulmonary effects and improved splanchnic blood flow suggested that LAM1-3 attenuated the development of a systemically induced secondary lung injury rather than of the primary lung injury associated with smoke inhalation." 06/01/2013 - "The purpose of this study is to investigate whether GLN has a beneficial effect on smoke inhalation induced lung injury. " 02/01/2009 - "In vitro systems are frequently used to study mechanisms of mainstream cigarette smoke (MS)-induced lung injury. " 01/01/2009 - "This review represents a toxicological approach to investigation of cigarette smoke-induced lung injury, with a focus on laboratory studies and an emphasis on inflammatory mechanisms. " 10/01/2006 - "C57BL/6 mouse groups were subjected to smoke from 3, 6 or 12 LC for 60 days and compared with mice exposed to ambient air (EAA) in order to study lung injury by morphometrical and biochemical methods. "

Therapies and Procedures

1.	Positive-Pressure Respiration (PEEP) 02/01/2011 - "When volume therapy was liberal, high PEEP (HighP/Vol+) improved the Pao₂/Fio₂ index (416 ± 80 mm Hg) compared to low PEEP (LowP/Vol+, 189 ± 55 mm Hg; P < .05) but there was no difference in the median (interquartile range) lung injury score: 1.6 (1.2-1.9) and 1.9 (1.4-2.0). " 01/01/2007 - "Low Vt/high PEEP stabilized alveoli, improved oxygenation, and reduced lung injury. " 05/01/1994 - "Lung injury assessed morphologically was significantly greater in the groups ventilated with a PEEP below Pinf, and in these groups the site of injury was dependent on the level of PEEP. " 01/01/2014 - "Recent investigations suggest protection against so-called ventilation-associated lung injury with the use of lower tidal volumes and/or the use of higher levels of positive end-expiratory pressure (PEEP). " 01/01/2010 - "In hypervolemic animals, RM improved oxygenation above the levels observed with the use of positive-end expiratory pressure (PEEP), but increased lung injury and led to higher inflammatory and fibrogenetic responses. "
2.	Artificial Respiration (Mechanical Ventilation) 05/01/2013 - "The prone position (PP) has proven beneficial in patients with severe lung injury subjected to mechanical ventilation (MV), especially in those with lobar involvement. " 05/01/2015 - "The present study suggests that continued mechanical ventilation improves postoperative oxygenation and could potentially prevent aggravation of lung injury after CPB." 01/01/2015 - "We show in the present study that hyperinflation following repeated OES deteriorate arterial oxygenation and the severity of lung injury in a rabbit model of ARDS undergoing mechanical ventilation." 11/01/2014 - "This study was designed to compare the effects of conventional mechanical ventilation using a lung-protective strategy with MFV in a porcine model of lung injury. " 06/01/2014 - "However, there is accumulating evidence from both experimental and clinical studies that mechanical ventilation, especially the use of high VT and plateau pressure, may potentially aggravate or even initiate lung injury. "
3.	Mechanical Ventilators (Ventilator) 07/01/2014 - "Although understanding of the pathophysiology of ARDS has improved, to date there are no effective pharmacological interventions that target a specific mechanism, with the only potentially effective therapies to date aiming to limit ventilator-associated lung injury. " 04/01/2005 - "Protective effects of low respiratory frequency in experimental ventilator-associated lung injury." 10/01/2012 - "It frequently results in equivalent or improved oxygenation and ventilation at lower peak pressures than conventional ventilation, thus minimizing secondary ventilator-associated lung injury. " 09/01/2013 - "However studies over the past two decades have indicated that ventilators have the potential to cause or aggravate pulmonary injury. " 11/01/2011 - "In this study, we seek to compare emergency ventilator performance characteristics using a test lung simulating pediatric lung injury. "
4.	Transplantation (Transplant Recipients) 01/01/2013 - "Timing of umbilical cord blood derived mesenchymal stem cells transplantation determines therapeutic efficacy in the neonatal hyperoxic lung injury." 01/01/2013 - "MP inhibits the inflammatory response, reduces the products of lipid peroxidation and promotes survival of transplanted BMSC, thus improving the intermediate and longer term efficacy of BMSC transplantation for treatment of PQ-induced lung injury." 02/01/2012 - "BM-MSC transplantation improved LPS-induced lung injury independent of HIMF." 09/01/2009 - "In order to evaluate the clinical applicability of BMMSC transplantation, we tested whether engraftment of minimally cultured BMMSCs ameliorates progressive fibrotic lung injury. " 08/01/2015 - "The aim of this study was to determine the optimal cell type for transplantation to protect against neonatal hyperoxic lung injury. "
5.	Resuscitation 05/01/2003 - "Interventions such as antioxidant therapy and hypertonic saline resuscitation have a rational basis for use and have been shown to be effective in a rodent two-hit lung injury model. " 06/01/2013 - "This study evaluated the effect of NAC in association with fluid resuscitation on pulmonary injury in a controlled HS model in rats. " 09/01/2009 - "The rat RBC group did not show an expected inflammatory reaction related to a transfusion-induced lung injury, and a clinical relevance concerning this level of transient inflammatory reaction induced by HbVs is not known; however, attention to the early stage of resuscitation in ongoing studies of HbV is required." 07/01/2004 - "These results support earlier studies that indicated the potential application of HS and PTX in shock therapy and the increase in PMN-endothelial cell interaction and lung injury after LR resuscitation." 12/01/2015 - "The animals with lipopolysaccharide-induced ALI that received late resuscitation with any kind of fluids demonstrated aggravated pulmonary injury and respiratory function. "