Lung Injury

Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.
Also Known As:
Chronic Lung Injury; Lung Injuries; Pulmonary Injury; Chronic Lung Injuries; Injuries, Lung; Injuries, Pulmonary; Injury, Lung; Injury, Pulmonary; Lung Injuries, Chronic; Lung Injury, Chronic; Pulmonary Injuries
Networked: 8956 relevant articles (663 outcomes, 1166 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Inflammation
2. Ischemia
3. Hyperoxia
4. Pancreatitis
5. Sepsis (Septicemia)


1. Matthay, Michael A: 49 articles (08/2015 - 01/2002)
2. Garcia, Joe G N: 42 articles (12/2015 - 11/2003)
3. Deitch, Edwin A: 36 articles (12/2014 - 06/2002)
4. Schultz, Marcus J: 33 articles (12/2015 - 10/2006)
5. Cuzzocrea, Salvatore: 32 articles (09/2015 - 01/2002)
6. Choi, Augustine M K: 29 articles (11/2014 - 01/2002)
7. Mazzon, Emanuela: 27 articles (10/2011 - 01/2002)
8. Lu, Qi: 26 articles (12/2011 - 06/2002)
9. Slutsky, Arthur S: 25 articles (01/2016 - 06/2002)
10. Ryter, Stefan W: 25 articles (10/2013 - 05/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Lung Injury:
1. Bleomycin (Blenoxane)FDA LinkGeneric
2. OxygenIBA
3. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
4. CytokinesIBA
07/01/2014 - "In a murine model of TRALI, C1-inhibitor attenuated pulmonary levels of C3a associated with improved lung injury scores, but with persistent high levels of inflammatory cytokines."
06/01/2006 - "Intermittent ventilation has protective effects on the lung injury during CPB by decreasing granulocyte adhesion and the level of lung cytokines, alleviating the lung inflammatory reaction and endothelial cell injury."
01/01/2007 - "ARF may affect the lung via increased renal production or impaired clearance of mediators of lung injury, such as proinflammatory cytokines. "
12/15/2015 - "Initial studies of wild-type mice subjected to single-dose thoracic radiation (10 Gy) confirmed a significant increase in lung GADD45a expression within 24 h and persistent at 6 wk. Mice deficient in GADD45a (GADD45a(-/-)) demonstrated increased susceptibility to radiation-induced lung injury (RILI, 10 Gy) evidenced by increased bronchoalveolar lavage (BAL) fluid total cell counts, protein and albumin levels, and levels of inflammatory cytokines compared with RILI-challenged wild-type animals at 2 and 4 wk. Furthermore, GADD45a(-/-) mice had decreased total and phosphorylated lung Akt levels both at baseline and 6 wk after RILI challenge relative to wild-type mice while increased RILI susceptibility was observed in both Akt(+/-) mice and mice treated with an Akt inhibitor beginning 1 wk prior to irradiation. "
06/01/2015 - "The aim of the present study was to investigate the changes of various cytokines that may be involved in ablative radiation-induced lung injury in vitro and in vivo. "
5. Peroxidase (Myeloperoxidase)IBA
6. Oleic Acid (Oleate)IBA
7. ParaquatIBA
8. Antigen-Antibody Complex (Immune Complex)IBA
9. Immunoglobulin G (IgG)IBA
10. SmokeIBA

Therapies and Procedures

1. Positive-Pressure Respiration (PEEP)
2. Artificial Respiration (Mechanical Ventilation)
3. Mechanical Ventilators (Ventilator)
4. Transplantation (Transplant Recipients)
5. Resuscitation